Protein Alignment Nep3 and ECEL1

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_004817.2
• Gene: ECEL1 / 9427
• HGNCID: 3147
• Length: 775
• Species: Homo sapiens
• Alignment Length: 775
• Identity: 280/775 - (36%)
• Similarity: 430/775 - (55%)
• Gaps: 42/775 - (5%)

  Fly    19 GIQLNEATGHTGMQIRYHTARATWNWRSRNKTEKWLLITTFVMAITIFTLLIVLFTDGGSSDATK 83
            |..|..|...||.:    :....||.|      :..|::..|.|..:..:|..:.       |.|
Human    36 GFPLGAARSATGAR----SGLPRWNRR------EVCLLSGLVFAAGLCAILAAML-------ALK 83

  Fly    84 HVLHVQPHQKDCPSGNELPCLNKHCIFASSEIL-KSIDVTVDPCDDFYGYSCNQWIKNNPIPEGK 147
            ::..|......||.|    |..:.....::..| .::|.::|||.|||.::|..|::.:.||:.|
Human    84 YLGPVAAGGGACPEG----CPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDK 144

  Fly   148 STWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAKVYYESCLDADEHMEKLGAKPMNDLLLQI 212
            .|:||...:.:.|:..:|.:|.:|.......|:||.:.::.||||..| :|:||.:||.:::...
Human   145 LTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMRE-IERLGPRPMLEVIEDC 208

  Fly   213 GGWNV----TKSGYNVANWTMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPT 273
            |||::    .:.|. .|.|.:...|......|:...||...:..||:||||:||:|||.|||||.
Human   209 GGWDLGGAEERPGV-AARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPE 272

  Fly   274 ADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDARAQMIGVINFEKKLANITIPLED--RRNE 336
            ...|..:.::..|:|..|..:|.:|..||||:..:.:||.|  :..|::|||||:...|  ||:.
Human   273 RTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEI--LQVEQQLANITVSEHDDLRRDV 335

  Fly   337 EAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEE 401
            .:||:.:.|.||.|:.|.|.|....|...|   ...:::|.||:.|.|:::.:|.:|......
Human   336 SSMYNKVTLGQLQKITPHLRWKWLLDQIFQ---EDFSEEEEVVLLATDYMQQVSQLIRSTPHR-- 395

  Fly   402 GKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIF 466
               .|:|||||:.|..|:..||.|||:|...:.:.:.|||..:|:.|.|:...|...|.|:||:|
Human   396 ---VLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALF 457

  Fly   467 VRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDPVEL 531
            |.:.|...||...:|::.:|:......|:.|.|:|.:||..|..|...:..|:|:||::|.|..:
Human   458 VHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAV 522

  Fly   532 DKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAG 596
            ||:| |..:....||:|.:....::::.::|::.|.|:|:.|.:.||.:||||.|.|||:|||||
Human   523 DKEY-EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAG 586

  Fly   597 ILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIA 661
            |||...:|.:.|:|||:|.:|.::||||||.:||.|.:||:.||:..||...|..||..|:|||.
Human   587 ILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIV 651

  Fly   662 RQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFFVSF 726
            |.|..:.:..:.:|||.||||||||.||||.||||||:...:...: ..||.|..||.||||::|
Human   652 RLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPE-HPLPRLKYTHDQLFFIAF 715

  Fly   727 AQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786
            ||.||.....::..||:..|.|:|..:||:|::|..:||...|.|.....|||..||.||
Human   716 AQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	256/666 (38%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	256/666 (38%)