Protein Alignment Nep3 and Ece1

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 801
• Identity: 344/801 - (42%)
• Similarity: 492/801 - (61%)
• Gaps: 63/801 - (7%)

  Fly     1 MTRYKQTEFTED---DSSSIGGIQLNEATGHTGMQIRYHTARATWN-WRSRNKTEKWLLITTFVM 61
            |:.||:....|:   ||.|.|.:..|      |:|:.:.:.|:... |.:|...||.|::...::
  Rat    17 MSSYKRATLDEEDLVDSLSEGDVYPN------GLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLL 75

  Fly    62 AITIFTLLIVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEILKSIDVTVDPC 126
            |..:...|.              .|.:|...:..|     .||.:.|:..:|.||.|:|.|||||
  Rat    76 AAGLVACLA--------------ALGIQYRTRTPP-----VCLTEACVSVTSSILNSMDPTVDPC 121

  Fly   127 DDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAKVYYESCL 191
            .||:.|:|..|||.||:|:|.|.||||..|.:.||.||:::||....| .|:||:||:|||.:|:
  Rat   122 QDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTAS-ASEAEKKAQVYYRACM 185

  Fly   192 DADEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMGH---TLKILHNKYNFNCLFGWAIGED 253
            : :..:|:|.|||:.:|:.::||||:|      ..|...:   ||:::...|..:..|...:..|
  Rat   186 N-ETRIEELRAKPLMELIEKLGGWNIT------GPWAKDNFQDTLQVVTAHYRTSPFFSVYVSAD 243

  Fly   254 DKNSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDA-RAQMIGVI 317
            .|||:.:|||:||.||.||:.|||.|||:| .|||..|:.||.::..|||..:.|: |.||..::
  Rat   244 SKNSNSNVIQVDQSGLGLPSRDYYLNKTEN-EKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQIL 307

  Fly   318 NFEKKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYA 382
            :||..|||||||.|.||:||.:||.:...:|..|||.:||....:.....|  .:.:.|.:|||.
  Rat   308 DFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPV--EINESEPIVVYD 370

  Fly   383 PDFLKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYK-------GVRKALMGS 440
            .::|:.:|.:|     ....|..||||::|..||..:|.|.:.|:||.:       |.:|..:..
  Rat   371 KEYLRQVSTLI-----NSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPR 430

  Fly   441 DGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTR 505
                  |::|||||.|.:|||:|.:||:..|..:||..|.::|.||::||:.:|..|.|:|:.||
  Rat   431 ------WKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTR 489

  Fly   506 EKAIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNK 570
            ..|.|||:.|.:|||:|::|:||.||||.:.:....|:.||||.::...::.:....:|.:..|:
  Rat   490 RSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNR 554

  Fly   571 TNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREY 635
            ..|.|||..|||||:||||:|||||||||.||:..::|.:||||.:|||:|||||||||||||||
  Rat   555 DQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREY 619

  Fly   636 DKFGNINRWWDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRT 700
            ||.||:..||.:.|:|.|.:::||:.:||:.|.:||..:||:.||||||||||||||||.|||..
  Rat   620 DKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNW 684

  Fly   701 KSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEF 765
            ......:.: ||.|.||.:||||:.|||||||..|.|::...:..||||||:|||||:|||.|||
  Rat   685 VKKNGAEQI-LPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEF 748

  Fly   766 AEVFQCKPGKRMNPTEKCEVW 786
            :|.|:|..|..|||..|||||
  Rat   749 SEHFRCPLGSPMNPRHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	309/671 (46%)
Ece1	XP_006239337.1	M13	118..767	CDD:341056	309/671 (46%)