Protein Alignment Nep3 and mmel1

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 768
• Identity: 281/768 - (36%)
• Similarity: 440/768 - (57%)
• Gaps: 44/768 - (5%)

  Fly    46 SRNKTEKWLLITTFVMAITIFTL-----LIVLFTDG-----GSSDATKHVLHVQPHQKDCPSGNE 100
            ::.:..:|.::...:..|.:...     ||||:|..     ..:|::|.:    .::.|..|.
Zfish    15 TKPRKHRWTVVEIGLSVIVLLMSCALAGLIVLYTSALRERFNINDSSKGL----KYRSDADSN-- 73

  Fly   101 LPCLNKHCIFASSEILKSIDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIR 165
             .|....|:.|::.:|:::|.:||||.:||.|:|..||:.:.|||..|....|..|....:::::
Zfish    74 -VCTTPQCVTAAARLLQNMDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELEIVLK 137

  Fly   166 NVLEKPAKSFKSDAERKAKVYYESCLDADEHMEKLGAKPMNDLLLQIGGWNVTK---SGYNVANW 227
            .|||...|..: :|.:|||..|.||:: :..:|:..::|:..|:..||.|.|..   :|.:...|
Zfish   138 GVLEMENKDDR-EAFKKAKTLYSSCMN-EILIEQRDSQPLLRLIDSIGDWPVASEVWNGTSEQTW 200

  Fly   228 TMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYI 292
            ::..||.:|:.:||...:....:..||::|||::|.:||..|.:|:.|||.: ..|::||...|:
Zfish   201 SLEDTLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLS-DGNYKKVREAYL 264

  Fly   293 EYMTKVCVL------LGANESDARAQMIGVINFEKKLANITIPLEDRRNEEAMYHPMQLR---QL 348
            |:|..:..:      |..:|......|..|:..|..:||.|.|.|:|.:...:|:.|.||   |.
Zfish   265 EFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYNKMTLREAQQT 329

  Fly   349 SKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLNNYLVWQ 413
            ..|..| |||.:....|..|...|..||.:|:|...:|:.||:::.|....     ||.|||||.
Zfish   330 FNLNGF-NWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHR-----TLQNYLVWM 388

  Fly   414 AVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPA 478
            .:....|.:|:.|:|.....||||.|:...|..||.||......:..||||::||:.|.|.||..
Zfish   389 LIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFSGNSKRM 453

  Fly   479 AEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDP--VELDKKYAELNIT 541
            ..::|.:|:||:...|:.|:|:|:|::.||.|||..||:.||:||:||:.  .:||::||.||.:
Zfish   454 VGELIKKIQEAYVETLEELSWMDEQSKVKAREKAMAISEQIGYPDHILEEENKKLDQEYAHLNFS 518

  Fly   542 PNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDIN 606
            ...||||.::....:.:...|:|.:||:...|.:....|||:|:..:|||||||||||.|||...
Zfish   519 EENYFENILENLAASAQKGHKKLREPVDPDMWIIGAAVVNAFYSHNRNQIVFPAGILQPPFFSEK 583

  Fly   607 NPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYSGYK--- 668
            ..::||||.:|:|:|||:||.|||.||.:||.||:..||.:.|.|||.::|:|:..||..:.
Zfish   584 QLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQSKCMVEQYGRFSWKL 648

  Fly   669 MNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSS 733
            ..|:.::|..|||||||||||::.||.||.:. .:|:.:..:||||::.|.||||::||||||.:
Zfish   649 AGGQNVSGITTLGENIADNGGVRQAYKAYVKW-VEREGEEPRLPGLDMNHKQLFFLNFAQVWCGA 712

  Fly   734 TTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786
            ...|..:..::.|||||.::||:|:|.|.:.|:|.|.|..|..|||.|||.||
Zfish   713 CRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	262/677 (39%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	262/677 (39%)