Protein Alignment Nep3 and Ece2

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_038944493.2
• Gene: Ece2 / 408243
• RGDID: 1303039
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 737
• Identity: 306/737 - (41%)
• Similarity: 444/737 - (60%)
• Gaps: 52/737 - (7%)

  Fly     1 MTRYKQTEFTEDD--SSSIGGIQLNEATGHTGMQIRYHTARATWNWRSRNKTEKWLLITTFVMAI 63
            |..||:.:..:::  ..::.|..:.::. ..|.|     .|....:.|..:.|..|.....|:|.
  Rat    92 MVEYKRAKLQDEELPEVTVEGRAIQDSL-EVGSQ-----KRTRQLFGSHTQLELVLAGLILVLAA 150

  Fly    64 TIFTLLIVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEILKSIDVTVDPCDD 128
            .:...|:.|:              ||.|:....|    .|:.:.||..:.:||:|:|..|.||.|
  Rat   151 LLLGCLVALW--------------VQYHRDPVHS----TCITEACIRVAGKILESLDRGVSPCQD 197

  Fly   129 FYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAKVYYESCLDA 193
            ||.:||..||:.||:|.|:|.|.||..|...||.|::::||....:..|:||||.:.:|.|||..
  Rat   198 FYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLENSTFNSSSEAERKTRSFYLSCLHL 262

  Fly   194 DEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANW---TMGHTLKILHNKYNFNCLFGWAIGEDDK 255
             |.:|||||||:.||:.:|||||:|      ..|   .....||.:...|.....|...:|.|.|
  Rat   263 -ERIEKLGAKPLQDLIDKIGGWNIT------GPWDEDNFMEVLKAVAGTYRAAPFFTVYVGADSK 320

  Fly   256 NSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDARAQMIGVINFE 320
            :|:.::||:||.||.||:.|||.|:|.| .|||..|::||.::.:|||...:..||||..|:..|
  Rat   321 SSNSNIIQVDQSGLFLPSRDYYLNRTAN-EKVLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELE 384

  Fly   321 KKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDF 385
            .:||.||:|.:.||:||.:||.|.:.:|..|||.::|.:.....:..:  .:.|.|.||||..::
  Rat   385 IQLATITVPQDQRRDEEKIYHKMSISELQTLAPSMDWLEFLSFLLSPL--ELGDSEPVVVYGTEY 447

  Fly   386 LKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGG-EEIWRY 449
            |:.:|::|.:.|.:     .|||||:|..|:..||.|.:.|..|.:.:.:.|.|:... ...|:.
  Rat   448 LQQVSELINRTEPS-----ILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQT 507

  Fly   450 CVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQ 514
            |:|:|::.:|||:|::||:..|..:||..||.||:|||.||:..|:||.|:|::||..|.|||:.
  Rat   508 CISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADA 572

  Fly   515 ISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQT 579
            |.|||||||:||:|.|||..|....::.:::|:|.:.:..::.|....:|.:|.::..|.|||||
  Rat   573 IYDMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT 637

  Fly   580 VNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRW 644
            |||||.||||:|||||||||.||:..|:||:||||.:||||||||||||||||||||:.||:..|
  Rat   638 VNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPW 702

  Fly   645 WDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQ---RTKSDRDV 706
            |.::|:..|...:.|:..||:.|::||..|||.|||||||||||||||||:||:   |...:..
  Rat   703 WQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ- 766

  Fly   707 DILKLPGLNLTHSQLFFVSFAQ 728
               .||.:.||:.|||||.|||
  Rat   767 ---PLPAVGLTNHQLFFVGFAQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	281/613 (46%)
Ece2	XP_038944493.2	None