Protein Alignment Nep3 and phex

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001307259.2
• Gene: phex / 386969
• ZFINID: ZDB-GENE-030103-2
• Length: 745
• Species: Danio rerio
• Alignment Length: 726
• Identity: 270/726 - (37%)
• Similarity: 415/726 - (57%)
• Gaps: 62/726 - (8%)

  Fly    97 SGNELPCLNKHCIFASSEILKSIDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQ 161
            :.||..||..||:.|:..||..:|.:||||||||.|:|..|::.|||||..|::|.:..|.|...
Zfish    46 ASNEDLCLGPHCVEAAGSILSKMDQSVDPCDDFYQYACGGWLRENPIPEDSSSYGIYPWLRQNVD 110

  Fly   162 LIIRNVLEKPAKSFKSDAERKAKVYYESCL--------DADEHMEKLGAKP-----MNDLLLQIG 213
            |.::.:||:|.:|...:|.:||||.|.||:        ||:..::.|..|.     :.|.|....
Zfish   111 LKLKELLEQPVRSGDIEAVKKAKVLYASCMNESALEIEDANPLLKNLKQKEFRWPVLGDALGSSS 175

  Fly   214 GWNVTKSGYNVANWTMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPT-ADYY 277
            .|  .:|.:|:.     .||..:.::::.:.|....:..|||||::::|::||..|:|.: .||.
Zfish   176 RW--VESQFNLL-----ETLAQIRSQHSKSVLIRLFVAPDDKNSNQYIIKLDQASLSLSSREDYI 233

  Fly   278 NNKTD--NHRKVLNEYIEYMTKVCVLLGANESDARAQMIGVINFEKKLANITIPLEDRRNEEAMY 340
            .|.|:  .:|:.|   :..|..|.|:|||:|..|.|||..|::||.|||.|.||.|:|.:|. ||
Zfish   234 TNTTEAQMYREAL---LRLMVDVSVMLGASEQAAEAQMKSVLDFEMKLAQIVIPYENRTSEN-MY 294

  Fly   341 HPMQLRQLSKLAPFLNW---------TDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKM 396
            :...|.:|.:..|..||         |:.:.:.      :::..|.|:|.||.:.|:|..:|...
Zfish   295 NKYSLSKLQRTVPDFNWLGFVRAVIDTELYPDL------KISSSEQVIVRAPQYFKDLFKLINAT 353

  Fly   397 EQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFA 461
            :..     |:.||::|::|.:..:.||:.|...|....:...|:......|..||:...|.:.:|
Zfish   354 DTR-----TVANYVIWRSVFSRITTLSRRFLYRYLDFARVTTGTTSLTPRWDKCVNYVENTLIYA 413

  Fly   462 VGAIFVRQAFHGESKPAAEQMIAEIREAF-----KMNLQNLTWVDKQTREKAIEKANQISDMIGF 521
            .|.:||.:.|..:.|...|::|..||.||     |.|    .|:|::|:.|||:||:.:...:|:
Zfish   414 AGRLFVDKHFQEDKKHMMEELINGIRWAFIDILEKEN----EWMDEETKRKAIDKAHAVLPKVGY 474

  Fly   522 PDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTP 586
            ||:||:...:::....|..|...||.|.:|...:..:|::..|.:.|.:|.|...|.||||:|:.
Zfish   475 PDFILNDTYINEDIKRLAFTMTDYFGNVMQTLKFIAQSDIGWLRKTVPRTEWFTNPTTVNAFYSS 539

  Fly   587 TKNQIVFPAGILQTPFF-DINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSI 650
            :.|||.||||.||.||| .:|.|:||::||:||::||||||.||:.||:|||.||:::||.:.||
Zfish   540 STNQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTHGFDNNGRKYDKDGNLDQWWSNSSI 604

  Fly   651 ERFNEKSECIARQYSGY--KMNGRTLNGKQTLGENIADNGGLKAAYHAYQR--TKSDRDVDILKL 711
            .||.||::|:..||:.|  |..|..:.||:||.||||||||::.::.||:|  .|....|:...|
Zfish   605 NRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGGIRESFRAYRRWVEKERGGVEEPLL 669

  Fly   712 PGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKR 776
            ||:.|||:||||:|:|.|.|::...|....|::...|||.::||||.:||.:||.:.|.|.....
Zfish   670 PGVGLTHNQLFFLSYAHVRCNAYRPEAARDQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSI 734

  Fly   777 MN-PTEKCEVW 786
            || .||.|.||
Zfish   735 MNRGTESCRVW 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	257/696 (37%)
phex	NP_001307259.2	None