Protein Alignment Nep3 and Mmel1

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 778
• Identity: 295/778 - (37%)
• Similarity: 448/778 - (57%)
• Gaps: 45/778 - (5%)

  Fly    39 RATW-NWRSRNKTEKWLLITTFVMAITIFTLLIVLFTDGGSSDATKHVLH--------VQPHQKD 94
            ||.| ..:|....|..|::...::.:.....|.|.::.|........:||        |:...:|
Mouse     4 RAGWCRKKSPGFVEYGLMVLLLLLLLGAIVTLGVFYSIGKQLPLLTSLLHFSWDERTVVKRALRD 68

  Fly    95 CPSGNELPCLNKHCIFASSEILKSIDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQM 159
            ....::: |....|:.|::.||:::|.:.:||::||.|:|..|::::.|||..|.:..|..|...
Mouse    69 SSLKSDI-CTTPSCVIAAARILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDE 132

  Fly   160 NQLIIRNVLEKPAKSFKSDAERKAKVYYESCLDADEHMEKLGAKPMNDLLLQIGGWNVTKSGYNV 224
            .::|::.|||......:...| |||..|.||:: ...:||..::|:..:|..:|||.|....:|.
Mouse   133 LEVILKGVLEDSTSQHRPAVE-KAKTLYRSCMN-QSVIEKRDSEPLLSVLKMVGGWPVAMDKWNE 195

  Fly   225 A---NWTMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTADYYNNKTDNHRK 286
            .   .|.:...|.:|::::|...|....|..||:|||||||.|||..|.:|:.:||..:.:|| |
Mouse   196 TMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNH-K 259

  Fly   287 VLNEYIEYMTKVCVLLGANE------SDARAQMIGVINFEKKLANITIPLEDRRNEEAMYHPMQL 345
            |...|:|:||.|..:|..::      :..|.:|..|:..|..|||.|:|.|.|.:..|:||.|.|
Mouse   260 VRKAYLEFMTSVATMLRKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHRMDL 324

  Fly   346 RQLSK---LAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLN 407
            .:|.:   |..| |||....|.:..|...:..||.||||...:|:||.|||     ......|:.
Mouse   325 MELQERFGLKGF-NWTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDII-----DSYSARTMQ 383

  Fly   408 NYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFH 472
            |||||:.|......||:.|::|....||||.|:...|..||.|||..|:.:..|||::::::||.
Mouse   384 NYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFS 448

  Fly   473 GESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDP--VELDKKY 535
            .:||....::|.:||..|..||..|.|:|:::::||.|||..|.:.||:|||||:.  ..||::|
Mouse   449 KDSKSTVRELIEKIRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIGYPDYILEDNNKHLDEEY 513

  Fly   536 AELNITPNAYFENNIQVAIYNLKSN----LKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAG 596
            :.|....:.||||.:|    |||:|    ||:|.:.|::..|.:....|||:|:|.:||||||||
Mouse   514 SSLTFYEDLYFENGLQ----NLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAG 574

  Fly   597 ILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIA 661
            |||.|||..:.|:|||||.:|:|:|||:||.|||.||.:||.||:..||.:.|...|.::|:|:.
Mouse   575 ILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMI 639

  Fly   662 RQYSGYK---MNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFF 723
            .||..:.   .:.:.:||..|||||||||||::.||.||.|..:|...| .:|||||||::||||
Mouse   640 YQYGNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLRWLADGGKD-QRLPGLNLTYAQLFF 703

  Fly   724 VSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786
            :::|||||.|...|..:..::.|.|||.::||:|:|.|:..|:|.|.|..|..|:|.::|.:|
Mouse   704 INYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	274/681 (40%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	274/680 (40%)