Protein Alignment Nep3 and ECE1

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 799
• Identity: 348/799 - (43%)
• Similarity: 498/799 - (62%)
• Gaps: 59/799 - (7%)

  Fly     1 MTRYKQTEFTEDDSSSIGGIQLNEATGH-TGMQIRYHTARATWN-WRSRNKTEKWLLITTFVMAI 63
            |:.||:....|:|...    .|:|...: .|:|:.:|:.|:... |.:|.:.||.|::...::|.
Human    26 MSTYKRATLDEEDLVD----SLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAA 86

  Fly    64 TIFTLLIVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEILKSIDVTVDPCDD 128
            .:...|.              .|.:| :|...||    .||::.|:..:|.||.|:|.|||||.|
Human    87 GLVACLA--------------ALGIQ-YQTRSPS----VCLSEACVSVTSSILSSMDPTVDPCHD 132

  Fly   129 FYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAKVYYESCLDA 193
            |:.|:|..|||.||:|:|.|.||||..|.:.||.||:::||....|. |:|||||:|||.:|::
Human   133 FFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV-SEAERKAQVYYRACMN- 195

  Fly   194 DEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMGH---TLKILHNKYNFNCLFGWAIGEDDK 255
            :..:|:|.|||:.:|:.::||||:|      ..|...:   ||:::...|..:..|...:..|.|
Human   196 ETRIEELRAKPLMELIERLGGWNIT------GPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSK 254

  Fly   256 NSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDA-RAQMIGVINF 319
            ||:.:|||:||.||.||:.|||.|||:| .|||..|:.||.::..|||..:.:| |.||..:::|
Human   255 NSNSNVIQVDQSGLGLPSRDYYLNKTEN-EKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDF 318

  Fly   320 EKKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPD 384
            |..|||||||.|.||:||.:||.:...:|..|||.:||....:.....|  .:.:.|.:|||..:
Human   319 ETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV--EINESEPIVVYDKE 381

  Fly   385 FLKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYK-------GVRKALMGSDG 442
            :|:.:|.:|     ....:..||||::|..||..:|.|.:.|:||.:       |.:|..:..
Human   382 YLEQISTLI-----NTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPR-- 439

  Fly   443 GEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREK 507
                |::|||||.|.:|||:|.:||:..|..:||..|.::|.||::||:.:|..|.|:|::||:.
Human   440 ----WKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS 500

  Fly   508 AIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTN 572
            |.|||:.|.:|||:|::|:||.||||.:.:....|:.||||.::...::.:....:|.:..|:..
Human   501 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ 565

  Fly   573 WGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDK 637
            |.|||..|||||:||||:|||||||||.||:..::||:||||.:|||:|||||||||||||||||
Human   566 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDK 630

  Fly   638 FGNINRWWDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKS 702
            .||:..||.:.|:|.|..::||:..|||.|.:||..:||:.||||||||||||||||.|||....
Human   631 DGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVK 695

  Fly   703 DRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAE 767
            ....: ..||.|.||::||||:.|||||||..|.|::...:..||||||:|||||:|||.|||:|
Human   696 KNGAE-HSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSE 759

  Fly   768 VFQCKPGKRMNPTEKCEVW 786
            .|:|.||..|||..|||||
Human   760 HFRCPPGSPMNPPHKCEVW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	312/671 (46%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	312/671 (46%)