Protein Alignment Nep3 and nep-18

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 788
• Identity: 185/788 - (23%)
• Similarity: 322/788 - (40%)
• Gaps: 158/788 - (20%)

  Fly    68 LLIVLFTD---GGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEILKSIDVTVDPCDDF 129
            |:|.|:..   .|||:|              |:|:...|.:|.|:...:.|....:.:||||:||
 Worm     3 LMIALWASLWPSGSSNA--------------PNGSPETCWSKECVGVLAMIKNYQNASVDPCEDF 53

  Fly   130 YGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIR-NVLEKPAKSFKSDAERKAKVYYESCLDA 193
            :.::|.::.::  :.:..| ||    ..|..||:.: ..:.:....|.|....:.:::.:||||.
 Worm    54 FEHTCGRYSEH--VMDDNS-WG----YVQYKQLLYQVFAIARKTNKFNSKPNEQLRIFTKSCLDR 111

  Fly   194 DE-----------HMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMGHTLKILHNKYNFNCLFG 247
            .|           .:|:.|..||.|     ..||..|  ::::: .:...|.|..|:..|..:..
 Worm   112 KEMDEDTFQDLRNDIEERGGFPMID-----PNWNEEK--FDLSD-MLAKYLSINRNRMGFLSVEP 168

  Fly   248 WAIGEDDKNSSRHVIQIDQG---------GLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLL- 302
            :|..|.:|:.:|  :.:..|         |::                :..:.:.:|.:..:.|
 Worm   169 YAAIEGNKSVNR--LYVSPGPHWVYNWAMGIS----------------IYKDSVAFMLRRLLKLE 215

  Fly   303 --GANESDARAQMIGVINFEKKLANITIPLEDRRN----EEAMYHPMQLRQLSKLAPFLNWTDHF 361
              ..||:....:...::..|   ||.: .|.|.||    .:.|.....|..|.|:.|.::|.
 Worm   216 NRELNETIYDKEFAELVQLE---ANFS-TLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWI--- 273

  Fly   362 DNAMQMVGRRVTDDE--------VVVVYAPDFL----KNLSDIILKMEQTEEGKITLNNYLVWQA 414
             ..::.:.|..|.:|        |.|..|.::.    :.|:.|     .||..|..|.||||
 Worm   274 -KILKALARHGTSEEDEEKLLERVTVHGAGEYFFGENRELARI-----ATETPKSALANYLV--- 329

  Fly   415 VRTLTSCLSKPFRDA--------YKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQA- 470
            ||.|.. ::..|.|.        |..|.:.           .:|.:...:........:|:..:
 Worm   330 VRQLID-VALYFYDKDQPRQNKFYNHVDQQ-----------SFCATQVASFFPMPSMNVFIESSQ 382

  Fly   471 FHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKY 535
            |..|:....|:|..:|:..::.......:::.:.||..|.|.|.|....|...|......|:|.|
 Worm   383 FKIENLKVIEEMFVKIKAEYEQIFTENEYLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMY 447

  Fly   536 AELNI----TP--------NAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTK 588
            ..||.    :|        ..:.|..::..:::..     || |||...:|     .:|.|.|..
 Worm   448 ETLNFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTP-----LD-PVNLKMFG-----THAAYQPYP 501

  Fly   589 NQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWW---DSKSI 650
            |........|..|:.|.:.|.:.|:|.:|.|:|||:.||||...|:.|:.|...::|   .:.|.
 Worm   502 NHFYINLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSN 566

  Fly   651 ERFNEKSECIARQYSGYKMNGRT--LNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPG 713
            ..:..:.:|:..|||.||..|..  :||.....|...|:.|::.|:..:::.|.:   |..:|||
 Worm   567 TEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEKVKKE---DRFRLPG 628

  Fly   714 LNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMN 778
            |.::..||||.::|...|...........|....|..:::||.|.:.|:.||||.|.|.....||
 Worm   629 LEMSEEQLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMN 693

  Fly   779 PTEKCEVW 786
            |..||:::
 Worm   694 PEMKCKLY 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	171/726 (24%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	171/726 (24%)