Protein Alignment Nep3 and Nep4

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_061501026.1
• Gene: Nep4 / 1273777
• VectorBaseID: AGAMI1_013990
• Length: 1007
• Species: Anopheles gambiae
• Alignment Length: 777
• Identity: 283/777 - (36%)
• Similarity: 405/777 - (52%)
• Gaps: 118/777 - (15%)

  Fly   111 ASSEILKS-IDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTF--------------------- 153
            |...|:|. :|...|||||||.|:|..|.:.||||:.|:...||
Mosquito   248 AQVAIMKQYMDPDADPCDDFYQYACGNWDRVNPIPKDKAALDTFELLRESLDLVLKQLLLEGEPA 312

  Fly   154 ------------------------------------------------------GKLEQ------ 158
                                                                  |:.|.
Mosquito   313 GLLDVENALSTVRSQPDGTKKSTSTTTTAASAGWPTTTVTGGPAQQQLHRVRKRGRAENRNRSGR 377

  Fly   159 --MNQLIIRN-----VLEKPAKSFKSDAERKAKVYYESCLDADEHMEKLGAKPMNDLLLQIGGWN 216
              .|:||||:     |..|.......|||.||:..:.||::. |.:|:.|.:|:..||..:|||.
Mosquito   378 AVQNKLIIRSAQVKRVRRKRELLINDDAEMKARHLFVSCMNY-ELIERRGLEPLRTLLHSLGGWP 441

  Fly   217 V------TKSGYNVANWTMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTAD 275
            |      .:|.::..|.|..      ..:||.:.|....:|.|.|||..:::|.||..|.|||.|
Mosquito   442 VLEPHTWDESSFDWLNLTAA------LRRYNNDVLIVEWVGPDIKNSDENIVQFDQTSLGLPTRD 500

  Fly   276 YYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDARAQMIGVINFEKKLANITIPLEDRRNEEAMY 340
            ||  ....:||.|..|.::|.:|..||......||.....:|.||.:|||||...|:|.|...:|
Mosquito   501 YY--LQPGNRKYLEAYRQFMLEVIGLLDVPADTARQATDEMIEFETQLANITSTPEERNNVSTLY 563

  Fly   341 HPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKIT 405
            ..:.|.||.:..|.:|||.:.....:   |.|.....||::|..::::|.::|   :|||...:.
Mosquito   564 RKLMLDQLQEEVPQINWTHYLTIVTE---RPVNGSSFVVMFAMSYMRDLVELI---DQTEPRIVA 622

  Fly   406 LNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQA 470
              |||:|:.||...:.|...|..|.:....||.|.:.....|:.||:..|..:|.||||:|||:.
Mosquito   623 --NYLLWRFVRHRINNLDDRFLGAKQRFSNALFGRERNPPRWKNCVTQVNANMGMAVGAMFVRRY 685

  Fly   471 FHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKY 535
            |...||.....|..|:::||:..|....|:|..||:.|.:|.|.:|..||:||:||||.:|..:|
Mosquito   686 FDENSKRDTLTMTHELQDAFREILGRTGWIDMATRQLAEQKVNAMSLRIGYPDFILDPEQLSARY 750

  Fly   536 AELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQT 600
            |.|.|.|:.||||.:.|..:..:::.::|.||||||.|...|..|||||:..||||:|||||||.
Mosquito   751 ATLEIHPDRYFENTLNVLSHIRRTDQEKLGQPVNKTAWHTAPAVVNAYYSRNKNQIMFPAGILQP 815

  Fly   601 PFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYS 665
            ||:..:.||::|:|.:|||:||||||.|||:||.:|:.||:.|||..::||.|:|::.|:..||.
Mosquito   816 PFYHRHLPKAINYGGIGVVIGHELTHGFDDKGRLFDRDGNLYRWWSDRAIEEFHERAACLVEQYG 880

  Fly   666 GYKMN--GRTLNGKQTLGENIADNGGLKAAYHAYQR---TKSDRDV-DILKLPGLNLTHSQLFFV 724
            .|::.  ...|:|:.|.|||||||||:|.|:.||.:   .::||.| :...|||||:|.:||||:
Mosquito   881 RYRIAEVDVQLDGENTQGENIADNGGIKQAFLAYSKWLAAQTDRRVLEAETLPGLNVTRTQLFFL 945

  Fly   725 SFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786
            :|||:||.:...|....:::...|||.:|||||||||.::||..:.|..|..|||..||.||
Mosquito   946 NFAQIWCGAMRPEATRNKLKTAVHSPGRFRVIGTLSNSEDFAREYHCPVGSTMNPPGKCSVW 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	276/760 (36%)
Nep4	XP_061501026.1	None