Protein Alignment Nep3 and Ece2

DIOPT Version :10

• Sequence 1: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 793
• Identity: 333/793 - (41%)
• Similarity: 479/793 - (60%)
• Gaps: 50/793 - (6%)

  Fly     1 MTRYKQTEFTEDDSSSIGGIQLNEATGHTGMQIRYHTARATWNWRSRNKTEKWLLITTFVMAITI 65
            |..||:.:..:::|..   |.:........:::.:. .|....:.|..:.|..|.....|:|..:
Mouse    14 MVEYKRAKLRDEESPE---ITVEGRATRDSLEVGFQ-KRTRQLFGSHTQLELVLAGLILVLAALL 74

  Fly    66 FTLLIVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEILKSIDVTVDPCDDFY 130
            ...|:.|:.....:.:|                    |:.:.||..:.:||:|:|..|.||.|||
Mouse    75 LGCLVALWVHRDPAHST--------------------CVTEACIRVAGKILESLDRGVSPCQDFY 119

  Fly   131 GYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAKVYYESCLDADE 195
            .:||..||:.||:|.|:|.|.||..|...||.|::::||....:..|:||||.:.:|.|||.: |
Mouse   120 QFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRSFYLSCLQS-E 183

  Fly   196 HMEKLGAKPMNDLLLQIGGWNVTKSGYNVANW---TMGHTLKILHNKYNFNCLFGWAIGEDDKNS 257
            .:|||||||:.||:.:|||||:|      ..|   :....||.:...|.....|...:..|.|:|
Mouse   184 RIEKLGAKPLRDLIDKIGGWNIT------GPWDEDSFMDVLKAVAGTYRATPFFTVYVSADSKSS 242

  Fly   258 SRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANESDARAQMIGVINFEKK 322
            :.::||:||.||.||:.|||.|:|.| .|||..|::||.::.||||...:..|.||..|:..|.:
Mouse   243 NSNIIQVDQSGLFLPSRDYYLNRTAN-EKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQ 306

  Fly   323 LANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLK 387
            |||||:|.:.||:||.:||.|.:.:|..|||.::|.:.....:..:  .:.|.|.||||..::|:
Mouse   307 LANITVPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPL--ELGDSEPVVVYGTEYLQ 369

  Fly   388 NLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGG-EEIWRYCV 451
            .:|::|.:.|.:     .|||||:|..|:..||.|.:.|..|.:.:.:.|.|:... ...|:.|:
Mouse   370 QVSELINRTEPS-----ILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCI 429

  Fly   452 SDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQIS 516
            |:|::.:|||:|::||:..|..:||..||.||.|||.||:..|.:|.|:|::||..|.|||:.|.
Mouse   430 SNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIY 494

  Fly   517 DMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVN 581
            |||||||:||:|.|||..|....::.:::|:|.:.:..::.|....:|.:|.::..|.|||||||
Mouse   495 DMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVN 559

  Fly   582 AYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWD 646
            |||.||||:|||||||||.||:..|:||:||||.:|||||||||||||||||||||.||:..||.
Mouse   560 AYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 624

  Fly   647 SKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQ---RTKSDRDVDI 708
            ::|:..|...:.|:..|||.|::||..|||.|||||||||||||||||:||:   |...:..
Mouse   625 NESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ--- 686

  Fly   709 LKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKP 773
             .||.:.||:.|||||.|||||||..|.|::...:..|||||::|||:|||||.::|...|.|..
Mouse   687 -PLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 750

  Fly   774 GKRMNPTEKCEVW 786
            |..|||.:.||||
Mouse   751 GSPMNPGQLCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep3	NP_523417.2	M13	123..784	CDD:341056	308/667 (46%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	308/667 (46%)