Protein Alignment pico and Raph1

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_006496385.1
• Gene: Raph1 / 77300
• MGIID: 1924550
• Length: 1318
• Species: Mus musculus
• Alignment Length: 1338
• Identity: 330/1338 - (24%)
• Similarity: 505/1338 - (37%)
• Gaps: 436/1338 - (32%)

  Fly    95 VIGAGAGAGVKLRR--HSDRPLTP--------EAKQLSHTYRISMANLEDS----QESELDQILG 145
            :.||..|...:|.:  .||:|..|        |....:.:||.|:.||.::    :..:||.::.
Mouse    27 MFGAWLGELDRLTQSLDSDKPKEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMA 91

  Fly   146 ELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSA-----PTMVSMSASSSRSHSRTN 205
            :|..:|.::|        ::.:.::..|:..|....:||...     .|:...|:||:|:...::
Mouse    92 DLCSIEQELS--------SIGSGNSKRQVTEPKVPQKLPAGRHTSKHGTLRGPSSSSNRTTKPSH 148

  Fly   206 STISAD--VSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREPRTES- 267
            :..|.|  .:....:.:|.:          ..:...:|:.|.|          :||.:..||.|
Mouse   149 ANYSLDDITAQLEQASLSMD----------EAAQQSLVEDPKP----------LVTNQHRRTASA 193

  Fly   268 ---PDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQQ----HHQHQ----------------Q 309
               .|.::......|..|..|:|||..||...:..:.|:    .||.|                :
Mouse   194 GTVSDAEARSISNSSRSSITSAASSMDSLDIDKVTRPQELDLTTHQGQPITEHAISLSCPSKQAK 258

  Fly   310 HHQHQQQQQKPQLAGAEKLHH-----------HGVHGQ--HGGQQSGANSITKADKIQLALHKLE 361
            ||....::|      ||...|           ..:.|:  |...:....:..||:||::||.|::
Mouse   259 HHSDFTEEQ------AELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIK 317

  Fly   362 SAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFED 426
            .|.:::|.::...||.:||:::||||.....|...|.||:|.....:|:|||.:.:|||||:|||
Mouse   318 EAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFED 382

  Fly   427 HELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPG----PQMAPGCQHDEQTRQMLLDEF 487
            ||.||:||:.|..|:.|:::|.:|.:|..||..|:.||.|    .:||      ::.:::||:|.
Mouse   383 HENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMA------DRNKEVLLEEC 441

  Fly   488 F--DSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLAC-LNLFHGHNVYT 549
            |  .|....:::|.|::|.|.||.||:.:|:||:||:||.||.|.|.:|||.| |.|.| .|||.
Mouse   442 FCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDH-VNVYY 505

  Fly   550 GLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHK 614
            |..:|.|:|:|||.....|   ...:.|..:.:|.||.:|..||.:|:..||:.||||||:.:::
Mouse   506 GQDYRNKYKAPTDCCLALK---HPQIQKKSQYIKYLCCDDARTLHQWVNGIRIAKYGKQLYTNYQ 567

  Fly   615 SLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAI-SSMSNSTSGRTSRASSSS 678
                       :|:.::..|....|.|.|||.|      ||.||:| .|.||.::...|..|.:.
Mouse   568 -----------EALKRTESAYDWTSLSSSSIKS------GSSSSSIPESQSNHSNQSDSGVSDTL 615

  Fly   679 SSGCL---SDDNNAFDSEFTTGTIKRKPSMKPNLP---------LTTMTRQLKEVGEITICE--- 728
            .:|.:   |..::.|...:..|| :.:.|.|..:.         :..::.|.|.:...|..:
Mouse   616 PTGHIRSQSTVSSIFSEAWKRGT-QLEESSKARMESMNRSYTSLMPPLSPQTKIITPYTASQPSP 679

  Fly   729 -----------------------------SAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRR 764
                                         |:|..|:...:..|:||..:     .:..||||.:.
Mouse   680 PLPPPPPPPPPPPPPPPPPPPPLPSQSAPSSGSAATMFVKYSTITRLQN-----AAQHSGTLFKS 739

  Fly   765 P-----------------IAVPVATVV----------------KQTEPMGSASSTSSSSNS---- 792
            |                 |.||...|:                .|.:|:..|.|....|..
Mouse   740 PTPPAMQPLPLASQSKAQIVVPPNGVIPPPPPPPPPPTPGSAMAQLKPVPCAPSLPQFSPQPPPL 804

  Fly   793 --------------TPTPTPSICAKPPP----------GDSASLMCSSTLSLDSLPPPPPPPALD 833
                          ||.|.|.|.|..||          ..|||....|.:...::||.|.||.
Mouse   805 KIHQVQHLPQTAPPTPPPAPPITATVPPQAPPKPLVTIPPSASTKTVSPVVAQAVPPTPAPPV-- 867

  Fly   834 GSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPSSPSTPTPMSTPMI-MPNSNGSLPPAVPAKP 897
                              ||...:.|..:::..|:.|..|||...|.: ...|.|..||..|..|
Mouse   868 ------------------PPAKKQPVFPVSHIPPTPPVQPTPHPPPTLPKQQSFGVKPPPSPLSP 914

  Fly   898 MKPAVKQ-----------------------AAGGLKAAPPYKA---------------------- 917
            :...|||                       |:|..::.|..||
Mouse   915 VPSVVKQIASQFPPPPTPPPVDSQPLKSLPASGTPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPE 979

  Fly   918 ------PPDYVGPALLPGPPLPPPPPAQKKVSFADSPVLLRRKMCSPEPVLPQRSPSTTLSCHSS 976
                  ||....||..|.||.|||||                    |.||.|..||:..   ...
Mouse   980 SSLVFPPPPPPAPAPAPPPPPPPPPP--------------------PPPVPPTASPTPD---KGG 1021

  Fly   977 SSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESASNPPRDFLKDLQRVMRKKW 1041
            |......:..:||...||... .|.||:.:||.:|...|||       |..|.|........:..
Mouse  1022 SPGKKTSKMSSPGGKKPPPTP-QRNSSIKSGSCAEHPEPKR-------PSVDSLVSKFAPPAESG 1078

  Fly  1042 QVAQKCKAEPATTP-----HEVLGFRDFSNEDLLAAHNLNSGANSSHYYRETANVSHWVRKHYEY 1101
            ..:::....||..|     |                   .||.|
Mouse  1079 SPSKETPPPPAAPPKPGKLH-------------------LSGVN--------------------- 1103

  Fly  1102 AHNALYENVHAQ---SAAAAGVPGSG-----EATTPP----LPPPP-----------------GN 1137
                 ...:|.|   ||.|:.:.|.|     |..:||    .||||                 ||
Mouse  1104 -----LPGIHQQGIVSAKASVLSGRGKDVVVEFPSPPSDSDFPPPPPEIELPLPPIEIPAVFSGN 1163

  Fly  1138 S----------------VAAKKRPPPPPPKRSDKTHLT 1159
            :                .:.||.|||..|||:|.|.||
Mouse  1164 TSPKVAVVNPQPQLWSKTSVKKAPPPTRPKRNDSTRLT 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	36/84 (43%)
		PH_APBB1IP	489..614	CDD:269961	54/125 (43%)
Raph1	XP_006496385.1	RA_MRL_Lpd	320..409	CDD:340553	37/88 (42%)
		PH_APBB1IP	445..567	CDD:269961	54/125 (43%)