Protein Alignment pico and RAPH1

DIOPT Version :9

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_005246834.1
• Gene: RAPH1 / 65059
• HGNCID: 14436
• Length: 1302
• Species: Homo sapiens
• Alignment Length: 1287
• Identity: 334/1287 - (25%)
• Similarity: 505/1287 - (39%)
• Gaps: 349/1287 - (27%)

  Fly    95 VIGAGAGAGVKLRR--HSDRPLTP--------EAKQLSHTYRISMANLEDS----QESELDQILG 145
            :.||..|...||.:  .||:|:.|        |....:.:||.|:.||.::    :..:||.::.
Human    27 MFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMA 91

  Fly   146 ELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSA-----PTMVSMSASSSR------ 199
            :|..:|.::|        ::.:.::..||.......:||.|.     .|:..:|:||:|
Human    92 DLCSIEQELS--------SIGSGNSKRQITETKATQKLPVSRHTLKHGTLKGLSSSSNRIAKPSH 148

  Fly   200 -SHSRTNSTISADVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREP 263
             |:|..:.|...:.:|.|....::..               :::...|          :||.:..
Human   149 ASYSLDDVTAQLEQASLSMDEAAQQS---------------VLEDTKP----------LVTNQHR 188

  Fly   264 RTESPDNDS-----AFSDTVSLLSSESSASSNTSLQQQQQQQQQQ---HHQHQQHHQH------Q 314
            ||.|....|     :.|:: |..|..|:|||..||...:..:.|:   .||.|...:|      .
Human   189 RTASAGTVSDAEVHSISNS-SHSSITSAASSMDSLDIDKVTRPQELDLTHQGQPITEHAISLRCS 252

  Fly   315 QQQQKPQLAGAEKLHHHGVHGQHGGQQS---------GANSIT--------KADKIQLALHKLES 362
            .:|.|..:...|:......|.....:.|         .::.:|        ||:||::||.|::.
Human   253 SKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIKE 317

  Fly   363 APIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDH 427
            |.:::|.::...||.:||:::||||.....|...|.||:|.....:|:|||.:.:|||||:||||
Human   318 AQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDH 382

  Fly   428 ELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPG----PQMAPGCQHDEQTRQMLLDEFF 488
            |.||:||:.|..|:.|:::|.:|.:|..||..|:.||.|    .:||      ::.:::||:|.|
Human   383 ENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMA------DRNKEVLLEECF 441

  Fly   489 --DSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLAC-LNLFHGHNVYTG 550
              .|....:::|.|::|.|.||.||:.:|:||:||:||.||.|.|.:|||.| |.|.| .|||.|
Human   442 CGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDH-VNVYYG 505

  Fly   551 LGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKS 615
            ..:|.|:|:||||....|   ...:.|..:.:|.||.:|:.||.:|:..||:.||||||:
Human   506 QDYRNKYKAPTDYCLVLK---HPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLY----- 562

  Fly   616 LLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAI-SSMSNSTSGRTSRASSSSS 679
                  ::..:|:.::..|....|.|.|||.|      ||.||:| .|.||.::...|..|.:..
Human   563 ------MNYQEALKRTESAYDWTSLSSSSIKS------GSSSSSIPESQSNHSNQSDSGVSDTQP 615

  Fly   680 SGCLSDD---NNAFDSEFTTGT------IKRKPSMKPNLPLTTMTRQLKEVGEITI--------- 726
            :|.:...   ::.|...:..||      ..|..||  |.|.|::...|....:|..
Human   616 AGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESM--NRPYTSLVPPLSPQPKIVTPYTASQPSP 678

  Fly   727 ---------------------------CESAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRR 764
                                       ..|||..|....:..|:||..:     .|..||.|.:.
Human   679 PLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQN-----ASQHSGALFKP 738

  Fly   765 P-------------IAVPVATVVKQTEP------MGSASSTSSSSNSTPTPTPSICAKPPPGDSA 810
            |             |.||...||....|      .|||.:....:...|: .|...|.|||....
Human   739 PTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPS-LPQFSAPPPPLKIH 802

  Fly   811 SLMCSSTLSLDSLPPPPPPPA-------------LDGSEDQDVYGSQLSLASLPPPPPP------ 856
            .:...:.::..:.|||||.||             :............::.|:.|.|.||
Human   803 QVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 867

  Fly   857 EDVLAMNYAEPSSPSTPTPMSTPMIMPNSNG--SLPPAVPAKPMKPAVKQAAGGLKAAP------ 913
            :.....:|..||.|:.|.|:..| .:|....  :.||..|..|:...|||.|......|
Human   868 QPAFPASYIPPSPPTPPVPVPPP-TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME 931

  Fly   914 --PYKAPPDYVGPAL----------------LPGPPLPPPPPAQKKVSFADSPVLLRRKMCSPEP 960
              |.|..|..|.|..                :|.|..||||| :..:.|...|.       ||.|
Human   932 SQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP-ESSLVFPPPPP-------SPVP 988

  Fly   961 VLPQRSPSTTLSC--HSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESAS 1023
            ..|...|.|....  .|.|......:|.:||...||... .|.||:.:.|.:|...|||
Human   989 APPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP-QRNSSIKSSSGAEHPEPKR------ 1046

  Fly  1024 NPPRDFLKDLQRVMRKKWQVAQKCKAEPATTPHEVLGFRDFSNEDLLAAHNLN-SGANSSHYYRE 1087
             |..|.|........:....:::....||..|               ....|| ||.|
Human  1047 -PSVDSLVSKFTPPAESGSPSKETLPPPAAPP---------------KPGKLNLSGVN------- 1088

  Fly  1088 TANVSHWVRKHYEYAHNALYENVHAQSAAAAGVP---GSG-----EATTPP----LPPPP----- 1135
                               ...|..|...:|..|   |.|     |..:||    .||||
Human  1089 -------------------LPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETEL 1134

  Fly  1136 ------------GNS----------------VAAKKRPPPPPPKRSDKTHLT 1159
                        ||:                ::.||.|||..|||:|.|.||
Human  1135 PLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLT 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	36/86 (42%)
		PH_APBB1IP	489..614	CDD:269961	55/125 (44%)
		PH	494..605	CDD:278594	48/111 (43%)
RAPH1	XP_005246834.1	UBQ	321..402	CDD:294102	35/80 (44%)
		PH_APBB1IP	444..566	CDD:269961	55/136 (40%)
		PH	449..557	CDD:278594	48/111 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157312
Domainoid	1	1.000	106	1.000	Domainoid score	I6584
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2618
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42297
orthoMCL	1	0.900	-	-		OOG6_106466
Panther	1	1.100	-	-	O	PTHR11243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2645
SonicParanoid	1	1.000	-	-		X3810
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.780