DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pico and grb7

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_003201390.1	Gene:	grb7 / 563649	ZFINID:	ZDB-GENE-091118-23	Length:	530	Species:	Danio rerio

Alignment Length:	396	Identity:	100/396 - (25%)
Similarity:	178/396 - (44%)	Gaps:	60/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 VKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNL 434
            |:.|:.....:|:||..|.....|.::||...|...:.:|||:||...|.:||..|||||::...
Zfish   105 VRVFSDATHCRSVLVSSRATAHDVCQMLAQSAHCTDEESWALIEHHTALGLERCLEDHELVLQVQ 169

  Fly   435 MTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDE-QTRQMLLDEFFDSHNQLQMDG 498
            .:|..:...::||::...|...|.:|..:.|...::......: .|...|:.....|.:..::.|
Zfish   170 SSWPVEGDTKLLFRKNYAKYEFFKKPVSFFPEHMISDSADVTKGMTSSELVQNMVKSGSCPEIQG 234

  Fly   499 PLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTR------DLACLNLFHGHNVYTGLGWRKKW 557
            .|:::...||.||:.:||||.||||...|.::|..|      ||..||:|   .|:||   ||.:
Zfish   235 FLHVREGGKKSWKKLYFVLRRSGLYCSSKGQSKEPRHLQFTGDLEDLNVF---TVFTG---RKHY 293

  Fly   558 KSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCL 622
            .:|.::.|..|:..:...|   :.||::||:...:...|:||.|:.|:|.||..:::     |..
Zfish   294 GAPGEHVFCIKSSKERFRG---QDLKLMCADSEQSRTCWITAFRLFKHGTQLQQNYQ-----LSQ 350

  Fly   623 SRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDN 687
            ||....|:.....:.|.||:.::                ..|..:.||.           :.:.:
Zfish   351 SRLHKPSKPDSKFTDRDESMVAM----------------DFSGKSGGRV-----------IQNPH 388

  Fly   688 NAFDSEFTTG-TIKRKPSMKPNLPLTTMTRQLKEVGEITICESAGGDASSPERSGTLTRRHSRRK 751
            .|.::|...| :.:::.:::.:||..:...||..|..:           .|...|.::|..:.|.
Zfish   389 EAHNAEQEEGHSWRKREALRHSLPPNSHGSQLPAVHRV-----------QPWFHGGVSRTKAERL 442

  Fly   752 SQESNG 757
            .:|..|
Zfish   443 LEEQGG 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	26/80 (33%)
		PH_APBB1IP	489..614	CDD:269961	44/130 (34%)
		PH	494..605	CDD:278594	39/116 (34%)
grb7	XP_003201390.1	UBQ	103..185	CDD:294102	26/79 (33%)
		PH_APBB1IP	225..347	CDD:269961	44/130 (34%)
		PH	230..334	CDD:278594	38/112 (34%)
		BPS	367..408	CDD:286088	8/67 (12%)
		SH2_Grb7_family	423..530	CDD:198197	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740