DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pico and raph1a

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001353656.1	Gene:	raph1a / 557435	ZFINID:	ZDB-GENE-070912-156	Length:	1346	Species:	Danio rerio

Alignment Length:	1248	Identity:	321/1248 - (25%)
Similarity:	484/1248 - (38%)	Gaps:	292/1248 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VIGAGAGAGVKLRRHSD---------RPLTPEAKQLSHTYRISMANLEDSQES----ELDQILGE 146
            :.||..|...||.:..|         .||..::...:..||.|:.|:.::...    :||.::.:
Zfish    27 MFGAWLGELDKLTKSLDDGRPEKVQKAPLRQDSNMANMAYRFSVYNINEALNQGDAVDLDALMAD 91

  Fly   147 LSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSAPTMVSMS------------ASSSR 199
            |..:|.::|        .:..||:.:......|.|:|....|...|.|            ::||.
Zfish    92 LCSIEQELS--------TIGKPSSSSSRLGLTGDTKLRQKPPAGRSHSTKHTGGSSSSGGSTSSS 148

  Fly   200 SHSRTNSTISADVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREPR 264
            :.:...||:....||.||.....:...|..:......|...:......|.|........|.|.|.
Zfish   149 TRASPASTVRLSSSSSSSRPPLASNFSLDDITAQLEKASQSMDEAARQGSTPSAAYSSSTVRRPA 213

  Fly   265 ---------------TESPDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQ---QHHQHQQHH 311
                           ||........|...|:  :.:||||..||...:....|   |..|.|...
Zfish   214 SHHHHHRRTGSVGTVTEHEVRSFVHSSRASI--NSASASSMDSLDIDKPLSDQDGVQDGQGQPST 276

  Fly   312 QHQQQQQKPQL---AGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLESAPIRRLFVKAF 373
            :|....::..|   :.|.|..|.....:...:|       ||:||::||.|::.|.:::|.|:..
Zfish   277 EHSYLDRETSLILKSIAGKPSHLLTKEEQAAKQ-------KAEKIRVALEKIKEAQVKKLVVRVH 334

  Fly   374 TSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNLMTWH 438
            .||.:||:::||||.....|...|.||:|.....:|:|||.:.:|||||:|||||.||:||:.|.
Zfish   335 LSDESSKTMMVDERQTVRQVLDSLLDKSHCGYSLDWSLVEIITELQMERIFEDHENLVENLLNWT 399

  Fly   439 SDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQTRQMLLDEFF--DSHNQLQMDGPLY 501
            .|:.||::|.:|.:|..||..|:.||.|.:..  |:..::.::.||:|.|  .:.:..:::|.|:
Zfish   400 RDSTNRLMFIERIEKYALFKNPQNYLLGRKET--CEMADRNKEALLEECFGGSTISVPEIEGVLW 462

  Fly   502 MKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLAC-LNLFHGHNVYTGLGWRKKWKSPTDYTF 565
            :|.|.||.||:.:|:||:||:||.||.|.|.:|||.| |.|.| .|||.|..:|.|:|:||||..
Zfish   463 LKDDGKKSWKKRYFLLRASGIYYVPKGKAKASRDLVCFLQLDH-VNVYLGQDYRSKYKAPTDYCM 526

  Fly   566 GFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQ 630
            ..|   ...:.|..:.:|.||.:|:..|.:|:..||:.||||||:.:::           :|:.:
Zfish   527 VLK---HPQIQKKSQYIKYLCCDDVRMLHQWVNGIRIAKYGKQLYVNYQ-----------EAMRR 577

  Fly   631 SSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDD---NNAFDS 692
            :..|....|.|.|||.|     |.|.||...|.||.:|...|..|.::|||.:...   ::.|..
Zfish   578 TEAAHDWSSLSSSSIKS-----CSSSSSLPESQSNHSSQSDSGVSETTSSGHVRSQSVVSSIFSE 637

  Fly   693 EFTTGTIKRKPSMKPNLPLTTMTRQLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNG 757
            .:..|....:|.|:.:.|.....|                 ||.|.:...|.:....|.|.
Zfish   638 AWKRGNQADEPKMRIDGPPAQPAR-----------------ASYPLQLPPLPQSLQSRSSY---- 681

  Fly   758 SGTLKRRPIAVP----------------------VATVVKQTEPMGSASSTSSSSNSTP------ 794
            ||.....|.:.|                      |.|.......:.:.|...:....||
Zfish   682 SGVSPASPSSPPSPPPPPPPPPPLPNPTHHSTPVVFTKYSTLARLQNISQAPNHYKQTPLLAAQQ 746

  Fly   795 TPTPSICAKPPPGDSASLMCSSTLSLDSLPPPPPPPALDGSEDQDVYGSQLSLASLPPP--PPPE 857
            .|||.:   |||.....||.::|....|.||.||||                    |||  |.|.
Zfish   747 QPTPPV---PPPQCLKPLMNNTTEVASSPPPAPPPP--------------------PPPEMPVPG 788

  Fly   858 DVLAMNYAEPSSPS---TPTPMSTPMIMPNSNGSLPPAVPAKPMKPAVKQAAGGLK--------- 910
            ..:|:....|.||.   .|.|...|..: :|||.|||..|.:.:|.....:..||:
Zfish   789 SAMAVLKHAPISPQYTPPPPPEEDPSYL-HSNGYLPPPPPPEQLKYPPPLSTNGLQQFLAQKFPN 852

  Fly   911 -----------AAPPYKAPPDYVGPALLPGPPLPP-------PPPAQKKVSFADSPVLLRRKMCS 957
                       ..||...|..:..|....|||.||       ||....|.....||:
Zfish   853 MTYDFSPVQQDEEPPPPPPVCFSPPPQQSGPPAPPKTFTGGFPPQTAPKPGHGISPI-------- 909

  Fly   958 PEPVLPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESA 1022
             .||.|..||:.:| .....|..|.:....|.|.||.:..   |||.:...|:.::..:.|.:..
Zfish   910 -SPVPPSLSPTPSL-MKKQQSLSSGHSPNQPPPTLPKQYS---LSSKAPSVSAPISPTQSLVKQI 969

  Fly  1023 SNPPRDFLKDLQRVM-------RKKWQVAQKCKAE----PATTPHEVLGF--------------- 1061
            .|...|.|...:..:       :.|||...:.:.:    |...|...|.|
Zfish   970 VNQFPDTLDGSKGPISPPVVKNKPKWQPGGQAQPQSPEFPPPPPESTLEFPPPPAPSPPPASQPS 1034

  Fly  1062 -----------RDFSNEDL---------LAAHNLNSGANSSHYYRETANVSHWVRKHYEYAH--- 1103
                       ...||...         ....|.:..|.||..|:|:..|...|....:.:.
Zfish  1035 GKSGSPIKKSPSTSSNSSTGSGGKKPPPTPQRNSSMKATSSVEYQESKKVEDLVSMFGQTSQAPP 1099

  Fly  1104 ------NALYENVHAQSAAAAGVPG---------------------SGEATTPPL----PPPPGN 1137
                  ::...:...:|:.|...||                     |.:..:|||    ||||.:
Zfish  1100 SSFSTPSSTTGSPSKESSRALTKPGKINLANLPLALQGRQSHCRQSSADFPSPPLDCEFPPPPPD 1164

  Fly  1138 SVAAKKRPPPPPP 1150
            |   :..||||.|
Zfish  1165 S---ELLPPPPLP 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	38/86 (44%)
		PH_APBB1IP	489..614	CDD:269961	53/125 (42%)
		PH	494..605	CDD:278594	47/111 (42%)
raph1a	NP_001353656.1	UBQ	327..408	CDD:320785	37/80 (46%)
raph1a	NP_001353656.1	PH_APBB1IP	450..572	CDD:269961	53/125 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593082
Domainoid	1	1.000	96	1.000	Domainoid score	I7261
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2522
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25105
orthoMCL	1	0.900	-	-		OOG6_106466
Panther	1	1.100	-	-	O	PTHR11243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3810
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.750