DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pico and APBB1IP

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_061916.3	Gene:	APBB1IP / 54518	HGNCID:	17379	Length:	666	Species:	Homo sapiens

Alignment Length:	877	Identity:	226/877 - (25%)
Similarity:	336/877 - (38%)	Gaps:	312/877 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SAGMMVQPPPPGGMTMGITLGVVTPREPRT------------------ESPDNDSAFSDTVSLLS 282
            |.|:...|||             .|..||.                  |..|.|:..:|.|
Human    25 SLGVDTLPPP-------------DPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLV---- 72

  Fly   283 SESSASSNTSLQQQQQQQQQQHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGG-------- 339
            ::.|.:...::|.|::..|.||        |....|....:||..| .:|.:....|
Human    73 ADISEAEQRTIQAQKESLQNQH--------HSASLQASIFSGAASL-GYGTNVAATGISQYEDDL 128

  Fly   340 ---------------------QQSGANSITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLL 383
                                 .|....:..|||||:|||.||:.|.:::|.||...:|.::|||:
Human   129 PPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLM 193

  Fly   384 VDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQ 448
            ||||.....|...|.:|.|.....:|.|.|...:||:||.|||||.:|:.|..|..|..|::||.
Human   194 VDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFL 258

  Fly   449 QRPDKVTLFLRPE-LYLPGPQMAPGCQHDE----QTRQMLLDEFFDSHNQL--QMDGPLYMKADP 506
            ::.:|..:|..|: .||.........:.:|    :.::.||:|.|...:.:  :::|.||:|.|.
Human   259 EKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDG 323

  Fly   507 KKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVG 571
            ||.|||.:|:||:||:||.||.|||.:|||||...|...|:|.|...:.|:|:||||.|..|
Human   324 KKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLK--- 385

  Fly   572 DSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAAS 636
            ...:.|..:.:|.||.:|..||::|:..||:.||||.|:|:::.           ||:::..|:
Human   386 HPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQR-----------AVAKAGLAS- 438

  Fly   637 MRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKR 701
             |..::.::::|.|:|   .|:...:.:...:|:..:|:.|.|:.......:|..|:      .:
Human   439 -RWTNLGTVNAAAPAQ---PSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSK------DK 493

  Fly   702 KPSMKPNLPLTTMTRQLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRRPI 766
            ||::                          |:...|
Human   494 KPAL--------------------------GNHHDP----------------------------- 503

  Fly   767 AVPVATVVKQTE-----PMGSASSTSSSSNSTPTPTPSICAK-------PPPGDSASLMCSSTLS 819
            |||.|....::.     |:..:|.||.|      |...:.||       |.|.|
Human   504 AVPRAPHAPKSSLPPPPPVRRSSDTSGS------PATPLKAKGTGGGGLPAPPD----------- 551

  Fly   820 LDSLPPPPPPPALDGSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPSSPSTPTPMSTPMIMPN 884
             |.||||||||.||..|             ||||||       ::.||.
Human   552 -DFLPPPPPPPPLDDPE-------------LPPPPP-------DFMEPP---------------- 579

  Fly   885 SNGSLPPAVPAKPMKPAVKQAAGGLKAAPPYKAPPDYVGPALLPGPPLPPPPPAQKKVSFADSPV 949
                 |..||                  ||   ||.|.|.|....||.||||||.......||
Human   580 -----PDFVP------------------PP---PPSYAGIAGSELPPPPPPPPAPAPAPVPDS-- 616

  Fly   950 LLRRKMCSPEPVLPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTS 1014
                  ..|.|.:.:|.|                                             ..
Human   617 ------ARPPPAVAKRPP---------------------------------------------VP 630

  Fly  1015 PKRLQESASNP------PRDFLKDLQRVMRKK 1040
            ||| ||:..:|      .:||:.||.:.::||
Human   631 PKR-QENPGHPGGAGGGEQDFMSDLMKALQKK 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	34/86 (40%)
		PH_APBB1IP	489..614	CDD:269961	55/126 (44%)
		PH	494..605	CDD:278594	49/112 (44%)
APBB1IP	NP_061916.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..155		1/32 (3%)
		GRB7_RA	183..261	CDD:176382	31/77 (40%)
		PH_APBB1IP	307..428	CDD:269961	55/123 (45%)
		PH	311..419	CDD:278594	49/110 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..666		85/412 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157313
Domainoid	1	1.000	106	1.000	Domainoid score	I6584
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005410
OrthoInspector	1	1.000	-	-		otm42297
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.800