DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pico and Grb14

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_057928.1	Gene:	Grb14 / 50915	MGIID:	1355324	Length:	538	Species:	Mus musculus

Alignment Length:	331	Identity:	100/331 - (30%)
Similarity:	156/331 - (47%)	Gaps:	19/331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 RRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELL 430
            ::..:|.::.|..|::|.|...:....|.:||..|||....::|.|.|||..:.:||..|||||.
Mouse   104 KKQVIKVYSEDETSRALEVPSDITARDVCQLLILKNHYVDDNSWTLFEHLSHIGLERTVEDHELP 168

  Fly   431 VDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQ-HDEQTRQMLLDEFFDSHNQL 494
            .:.|..|..:..|::..::...|...|..|..:.|...::...: :.:::...:|..|..|....
Mouse   169 TEVLSHWGVEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFAAEMNGDRSPTQILQVFLSSSTYP 233

  Fly   495 QMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKS 559
            ::.|.|:.|...||.||:.:|.||.||||:..|..:|..|.|...:.|...:||..|..:||..:
Mouse   234 EIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQLFSEFSTSHVYMSLAGKKKHGA 298

  Fly   560 PTDYTFGF---KAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLC 621
            ||.|.|..   ||.|.       |.|||||||:..:...|:||||:.|.|.||:.::....:
Mouse   299 PTPYGFCLKPNKAGGP-------RDLKMLCAEEEQSRTCWVTAIRLLKDGMQLYQNYMHPYQ--- 353

  Fly   622 LSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDD 686
             .|....|||  .:.|||.|.:|:.:...|  |..|..|.:.:.:.|.......:....|||...
Mouse   354 -GRSACNSQS--MSPMRSVSENSLVAMDFS--GEKSRVIDNPTEALSVAVEEGLAWRKKGCLRLG 413

  Fly   687 NNAFDS 692
            |:...|
Mouse   414 NHGSPS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	26/84 (31%)
		PH_APBB1IP	489..614	CDD:269961	49/127 (39%)
		PH	494..605	CDD:278594	44/113 (39%)
Grb14	NP_057928.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		GRB7_RA	104..188	CDD:176382	26/83 (31%)
		PH_APBB1IP	228..349	CDD:269961	49/127 (39%)
		PH	233..339	CDD:278594	44/112 (39%)
		BPS	368..412	CDD:286088	11/45 (24%)
		SH2_Grb14	431..538	CDD:198277
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740