Protein Alignment pico and Grb10

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_038948235.1
• Gene: Grb10 / 498416
• RGDID: 1566234
• Length: 691
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 137/560 - (24%)
• Similarity: 222/560 - (39%)
• Gaps: 118/560 - (21%)

  Fly   270 NDSAFSDTVSLL------SSESSASSN-----TSLQQQQQQQQQQHHQHQQHHQHQQQQQK---- 319
            |..:.:|||.||      |::.||||:     .|.:|:.|:.|..|.|..:..|.:.||.:
  Rat   109 NMQSDTDTVPLLENGQSASNQPSASSSRGQPQASPRQKMQRSQPVHIQPLRRLQEEDQQLRTSSL 173

  Fly   320 -------PQLAGA-------------------------------EKLHHHGV-----------HG 335
                   |:|||.                               .||...|:           ..
  Rat   174 PAIPNPFPELAGGAPGSPPSVAPSSLPPPPSQPPAKHFPPGFQLAKLTRPGLWTKTTARFSKRQP 238

  Fly   336 QHGGQQSGANSITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADK 400
            ::..|...||::::....|:...:|      |..||.|:.||.||.:.:...|....:.:||..|
  Rat   239 KNQCQTDTANAVSRIPTSQMEKLRL------RKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYK 297

  Fly   401 NHVQMQSNWALVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLP 465
            :|....::|.||||...|.:||..||||::|....|..|:  ::.||::...|...|..|..:.|
  Rat   298 SHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSE--SKFLFRKNYAKYEFFKNPVNFFP 360

  Fly   466 GPQMAPGCQHDEQTRQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKT 530
             .||...||.....:..||..|.:|.:..::.|.|.:|...:|.||:.:..||.|||||..|..:
  Rat   361 -DQMVTWCQQSNGGQAQLLQNFLNSSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTS 424

  Fly   531 KNTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDR 595
            |..|.|..|......:::..:..:|::.:|.::....|   .:......:.|::|||||......
  Rat   425 KEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIK---PNKAKIEMKELRLLCAEDEQIRTC 486

  Fly   596 WLTAIRVCKYGKQLWDSH-----------------KSLLEDLCLSRD----------------DA 627
            |:||.|:.|||..|:.::                 :|:.|:..::.|                .|
  Rat   487 WMTAFRLLKYGMLLYQNYRIPQQRKGLAPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSA 551

  Fly   628 VSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDS 692
            ..:...|...||..::.:||..|....:::|.|....:...||.||..|..    :.......|.
  Rat   552 ALEEGHAWRKRSTRMNILSSQSPLHPSTLNSVIHRTQHWFHGRISREESHR----IIKQQGLVDG 612

  Fly   693 EFTTGTIKRKPSMKPNLPLTTMTRQLK-EVGEITICESAG 731
            .|    :.|.....|...:.|:..|.| ...:|..||..|
  Rat   613 LF----LLRDSQSNPKAFVLTLCHQQKIRNFQILPCEDDG 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	30/84 (36%)
		PH_APBB1IP	489..614	CDD:269961	36/141 (26%)
Grb10	XP_038948235.1	RA_GRB10	266..354	CDD:340558	31/89 (35%)
		PH_APBB1IP	383..505	CDD:269961	36/124 (29%)
		BPS	522..565	CDD:462644	7/42 (17%)
		SH2_Grb10	584..691	CDD:198278	17/73 (23%)