Protein Alignment pico and grb10a

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001004287.1
• Gene: grb10a / 446167
• ZFINID: ZDB-GENE-040822-32
• Length: 602
• Species: Danio rerio
• Alignment Length: 493
• Identity: 124/493 - (25%)
• Similarity: 199/493 - (40%)
• Gaps: 98/493 - (19%)

  Fly   259 TPREPRTESPDNDSAFSDTVSLLSSES----------------SASSNTSLQQQQQQQQQQHHQH 307
            :|..|. :..|.::..:|..||.|.||                .::.::.|...:.....:...|
Zfish    43 SPNHPE-DDVDLEALVNDMASLSSYESIYATCEIQHSDSAPLLHSTDSSGLHGNRVAPLPRAPSH 106

  Fly   308 QQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLES---------- 362
            :....|...|   :|..::.:|.|.|..            .:.:::|:....|.:
Zfish   107 KVTAPHSPAQ---RLRRSQPMHIHAVRR------------LQEEELQVRPASLPAIPNPFPELCS 156

  Fly   363 -------------APIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEH 414
                         .|.....:|.|:.||..|.:.|...|....|.:.|..|:|....:.|:||||
Zfish   157 PSGSPVLSPGSLPQPSESHIIKVFSEDGVGKVVEVTAGMMARDVCQFLVYKSHCLDDNCWSLVEH 221

  Fly   415 LGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQT 479
            ...|.:||..|||||:|........:  ::.||::...|...|..|..:.| .||...||....:
Zfish   222 HSLLGLERCLEDHELVVSVKACMPPE--SKFLFRKNYAKYEFFRNPLNFFP-EQMVAWCQESNGS 283

  Fly   480 --RQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLF 542
              :..||..|.:|.:..::.|.||||...:|.||:.:..||.|||||..|..:|..|.|..|:..
Zfish   284 IPQSQLLQNFLNSSSCPEIQGFLYMKETGRKSWKKLYMFLRRSGLYYSTKGMSKEPRHLQLLSDL 348

  Fly   543 HGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKS-CRSLKMLCAEDLPTLDRWLTAIRVCKYG 606
            ...|::|....||...:||||.|..|    .|.|:: .:.||||||||..:...|:||.|:.|:|
Zfish   349 EESNIFTVTTGRKMHNAPTDYQFCIK----PSKGRTELKELKMLCAEDEQSRTCWMTAFRLLKFG 409

  Fly   607 KQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRT 671
            ..|:.::|:..:...:        |:|...:||.|.:|:                 ::...||||
Zfish   410 ILLYQNYKTPHQRKTI--------SNFTTPVRSVSENSL-----------------VAMDFSGRT 449

  Fly   672 SRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNL 709
            .|.        :.:...|..:....|...||.|.:.|:
Zfish   450 GRV--------IDNPVEAQSAAMEEGHTWRKRSQRMNV 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	27/84 (32%)
		PH_APBB1IP	489..614	CDD:269961	48/125 (38%)
grb10a	NP_001004287.1	Ubl1_cv_Nsp3_N-like	173..264	CDD:475130	29/92 (32%)
		PH_APBB1IP	295..417	CDD:269961	48/125 (38%)
		BPS	433..476	CDD:462644	14/67 (21%)
		SH2_Grb10	495..602	CDD:198278