Protein Alignment pico and dos

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Alignment Length: 857
• Identity: 161/857 - (18%)
• Similarity: 246/857 - (28%)
• Gaps: 367/857 - (42%)

  Fly   496 MDGPLY----MKADPKK-----GWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHN----- 546
            ||...|    :|:.|.|     .|:|.:|.|:...:   |::        .||..:..||
  Fly     1 MDRTFYEGWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQ--------FCLEYYTDHNCRKLK 54

  Fly   547 ----------VYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAI- 600
                      |..||....: |....|.|..         |:.:....|.||....:..|:..|
  Fly    55 GVIDLDQCEQVDCGLRLENR-KQKFQYMFDI---------KTPKRTYYLAAETEADMRDWVNCIC 109

  Fly   601 RVCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSN 665
            :||    .|.|:.:|  .:|.|.   ||.    |...|::..||               ...:||
  Fly   110 QVC----HLHDTKQS--NELPLG---AVG----ADENRTQHTSS---------------SGGLSN 146

  Fly   666 STSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTRQLKEVGEITICESA 730
            ||...|:.:..||:                 ||...:.|: ||                     |
  Fly   147 STQNTTTTSLHSSA-----------------GTTAPQASV-PN---------------------A 172

  Fly   731 GGDASSPERSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQTEPMGSASSTSSSSNSTPT 795
            ||.|.                          .|||..:       :.:||.|.:..::|.
  Fly   173 GGSAQ--------------------------LRRPAVI-------EEQPMPSNAGNNNSD----- 199

  Fly   796 PTPSICAKPPPGDSASLMCSSTLSLDSLPPPPPPPALDGSEDQDVYGSQLSLASLPPPPPPEDVL 860
               |:.......:..:::|                  |.:.||.   ..||.|...|||.|...|
  Fly   200 ---SVYVNTEYSNRETMLC------------------DANFDQQ---ELLSAAQQQPPPSPATAL 240

  Fly   861 AMNY---------AEPSSPSTPTPMSTPMIMPNSNG---SLPP--AVPAKPMKPAVKQAAGGLKA 911
            .:|:         |..:............:..::||   .||.  .:..:.:..|..|....::|
  Fly   241 YLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQA 305

  Fly   912 APPYK-APPDYV--------GPALLPGPPLP---------PPPPAQK-KVSFADSP--------V 949
            :|... |...|:        .|..|||.|||         |..|... ...|.|:|        .
  Fly   306 SPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLN 370

  Fly   950 LLRRKMCSPE------------PVLPQRSPS------------------------TTLSCHSSSS 978
            |...:..||:            ....|||.|                        :|....||..
  Fly   371 LTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIE 435

  Fly   979 AGSAYQTYAP---------GPMLPPRADVARLS-------------------------------- 1002
            ..|...||:.         |.::||....::|:
  Fly   436 NESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFK 500

  Fly  1003 -------SLSNGSSSEVTSP----KRLQESASNPPRDFLKDLQRVMRKKWQ----VAQKCKAEPA 1052
                   .|...|.:|.|||    :|...||      |:::...:.|...|    |.|.....|.
  Fly   501 ENEKIPRDLPQLSDTENTSPAIVARRNAHSA------FIEESYDIPRSHQQPYYNVNQLLGERPV 559

  Fly  1053 TTPHEVLGFRDFSN-----------EDLLAAHNLNSGAN-----SSHYYRETANVSHWVRKHYEY 1101
            |:||.       ||           .||.|...:::.||     .:.....:...:..:.:|
  Fly   560 TSPHN-------SNPIAASTPNLMAADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRH--- 614

  Fly  1102 AHNALYENVHAQSAAAAGVPGS-------GEATTPPL-----PPPPGNSVAAKKRP----PPPPP 1150
                .|.|     ||...:.|:       .:|..||:     |...|.....:.:|    |..||
  Fly   615 ----CYTN-----AAPTKMEGNVFRYDFMEQADCPPVNRKLKPKVAGGLPVVEDKPPEEFPAKPP 670

  Fly  1151 KRSDKTHLTNRV 1162
            ...|:  |||::
  Fly   671 VGVDQ--LTNKL 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555
		PH_APBB1IP	489..614	CDD:269961	31/142 (22%)
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	28/137 (20%)