DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pico and Raph1

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_038939789.1	Gene:	Raph1 / 363239	RGDID:	1308387	Length:	1318	Species:	Rattus norvegicus

Alignment Length:	1317	Identity:	333/1317 - (25%)
Similarity:	515/1317 - (39%)	Gaps:	394/1317 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VIGAGAGAGVKLRR--HSDRPLTP--------EAKQLSHTYRISMANLEDS----QESELDQILG 145
            :.||..|...:|.:  .||:|..|        |....:.:||.|:.||.::    :..:||.::.
  Rat    27 MFGAWLGELDRLTQSLDSDKPKEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMA 91

  Fly   146 ELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSA-----PTMVSMSASSSRSHSRTN 205
            :|..:|.::|        ::.:.::..|:..|....:||.|.     .|:..:|:||:|:....:
  Rat    92 DLCSIEQELS--------SVGSGNSKRQVTEPKVAQKLPASRHTSKHGTLRGVSSSSTRTTRPPH 148

  Fly   206 STISADVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREPRTESPDN 270
            :..|.|..:......|     |.:......||....:||.........:.|.|:..|.|:.|  |
  Rat   149 ANYSLDDITAQLEQAS-----LSMDEAAQQSAVEDAKPPATNQHRRTASAGTVSDAEVRSVS--N 206

  Fly   271 DSAFSDTVSLLSSESSASSNTSLQQQQQQQQQQ----HHQHQQHHQHQQQQQKPQLAGAEKLHHH 331
            .|..|.|       |:|||..||...:..:.|:    .||.:...:|......|    :::..||
  Rat   207 SSRSSIT-------SAASSMDSLDIDKVTRPQELDLTAHQGKPITEHATSLSCP----SKQAKHH 260

  Fly   332 GVHGQHGGQQSGANSI---------------------------TKADKIQLALHKLESAPIRRLF 369
            ....:...|.:..:.:                           .||:||::||.|::.|.:::|.
  Rat   261 SDFTEEQAQLAPHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLV 325

  Fly   370 VKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNL 434
            ::...||.:||:::||||.....|...|.||:|.....:|:|||.:.:|||||:|||||.||:||
  Rat   326 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENL 390

  Fly   435 MTWHSDAGNRVLFQQRPDKVTLFLRPELYLPG----PQMAPGCQHDEQTRQMLLDEFF--DSHNQ 493
            :.|..|:.|:::|.:|.:|..||..|:.||.|    .:||      ::.:::||:|.|  .|...
  Rat   391 LNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMA------DRNKEVLLEECFCGSSVTV 449

  Fly   494 LQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLAC-LNLFHGHNVYTGLGWRKKW 557
            .:::|.|::|.|.||.||:.:|:||:||:||.||.|.|.:|||.| |.|.| .|||.|..:|.|:
  Rat   450 PEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDH-VNVYYGQDYRNKY 513

  Fly   558 KSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCL 622
            |:|||.....|   ...:.|..:.:|.||.:|..||.:|:..||:.||||||:.:::
  Rat   514 KAPTDCCLALK---HPQIQKKSQYIKYLCCDDARTLHQWVNGIRIAKYGKQLYTNYQ-------- 567

  Fly   623 SRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAI-SSMSNSTSGRTSRASSSSSSGCL--- 683
               :|:.::..|....|.|.|||.|      ||.||:| .|.||.::...|..|.:..||.:
  Rat   568 ---EALKRTESAYDWTSLSSSSIKS------GSSSSSIPESQSNHSNQSDSGVSDTLPSGHIRSQ 623

  Fly   684 SDDNNAFDSEFTTGTIKRKPSMKPNLP---------LTTMTRQLKEVGEITICE----------- 728
            |..::.|...:..|| :.:.|.|..:.         :..::.|.|.:...|..:
  Rat   624 STVSSIFSEAWKRGT-QLEESSKARMESMNRSYTSLMPPLSPQTKIITPYTASQPSPPLPPPPPP 687

  Fly   729 ---------------------SAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRRP------- 765
                                 |:|..|:...:..|:||..:     .:..||||.:.|
  Rat   688 PPPPPPPPPPPPPPLPSQSAPSSGSAATMFVKYSTITRLQN-----AAQHSGTLFKSPAPSAMQP 747

  Fly   766 ----------IAVPVATVV----------------KQTEPMGSASSTSSSSNS------------ 792
                      |.||...|:                .|.:|:..|.|....|..
  Rat   748 LPLASQSKAQIVVPPNGVIPPPPPPPPPPTPGSAMAQLKPVPCAPSLPQFSPQPPPLKIHQVQHL 812

  Fly   793 ------TPTPTPSICAKPPP----------GDSASLMCSSTLSLDSLPPPPPPPALDGSEDQDVY 841
                  ||...|.|.|..||          ..|||....|.:...::||.|.|| :..::.|.|:
  Rat   813 PQAAPPTPPAAPLIPATVPPQAPPKPLVTIPPSASTKMVSPVVAQAVPPTPAPP-VPPTKKQPVF 876

  Fly   842 GSQLSLASLPPPPP------PEDVL----AMNYAEPSSPSTPTP-----MSTPMIMPNSNGSLPP 891
                .::.:||.||      |...|    :.....|.||.:|.|     |::....|.:    ||
  Rat   877 ----PVSHIPPTPPVQPTPHPPPTLPKQQSFGVKPPPSPLSPVPSVVKQMASQFPPPPT----PP 933

  Fly   892 AVPAKPMKP----AVKQAAGGLKAAPPYK-----AP-PDY--------------VGPALLPGPPL 932
            .|.::|:||    ...|:...:||.|.::     || ||:              ..||.:|.||.
  Rat   934 PVDSQPLKPLPASVTPQSPPAVKAKPKWQPSSIPAPSPDFPPPPPESSLVFPPPPPPAPVPPPPP 998

  Fly   933 PPPPPAQKKVSFADSPVLLRRKMCSPEPVLPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRAD 997
            |||||.                  .|.||.|..||:..   ...|......:..:||...||...
  Rat   999 PPPPPP------------------PPPPVSPMASPTPD---KGGSPGKKTSKMSSPGGKKPPPTP 1042

  Fly   998 VARLSSLSNGSSSEVTSPKRLQESASNPPRDFLKDLQRVMRKKWQVAQKCKAEPATTP-----HE 1057
             .|.||:.:||.:|...|||       |..|.|........:....:::....||..|     |
  Rat  1043 -QRNSSIKSGSCAEHPEPKR-------PSVDSLVSKFAPPAESGSPSKETPPPPAAPPKPGKLH- 1098

  Fly  1058 VLGFRDFSNEDLLAAHNLNSGANSSHYYRETANVSHWVRKHYEYAHNALYENVHAQ---SAAAAG 1119
                              .||.|                          ...:|.|   ||..:.
  Rat  1099 ------------------LSGVN--------------------------LPGIHQQGILSAKPSV 1119

  Fly  1120 VPGSG-----EATTPP----LPPPP-----------------GNS----------------VAAK 1142
            :.|.|     |..:||    .||||                 ||:                .:.|
  Rat  1120 LSGRGKDAVVEFPSPPSDSDFPPPPPEIELPLPPIEIPAVFSGNTSPKVAVVNPQPQLWSKTSVK 1184

  Fly  1143 KRPPPPPPKRSDKTHLT 1159
            |.|||..|||:|.|.||
  Rat  1185 KAPPPTRPKRNDSTRLT 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	36/86 (42%)
		PH_APBB1IP	489..614	CDD:269961	54/125 (43%)
		PH	494..605	CDD:278594	47/111 (42%)
Raph1	XP_038939789.1	RA_MRL_Lpd	320..409	CDD:340553	37/88 (42%)
Raph1	XP_038939789.1	PH_APBB1IP	445..567	CDD:269961	54/125 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351280
Domainoid	1	1.000	105	1.000	Domainoid score	I6512
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2739
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46447
orthoMCL	1	0.900	-	-		OOG6_106466
Panther	1	1.100	-	-	O	PTHR11243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3810
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.750