DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pico and Gab1

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_038953748.1	Gene:	Gab1 / 361388	RGDID:	1311085	Length:	729	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	155/784 - (19%)
Similarity:	229/784 - (29%)	Gaps:	346/784 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 GCQH----DEQTRQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSG-------LYYF 525
            ||..    ::|.|:.|   ||                   :.|||..|||||..       |.|:
  Rat    11 GCHSALGPEDQARECL---FF-------------------QAWKRRWFVLRSGRLTGDPDVLEYY 53

  Fly   526 PKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDL 590
            ..:..|....:..|||.  ..|..||.:.|| :....|.|....:.         .:..|.|:..
  Rat    54 KNDHAKKPIRIIDLNLC--QQVDAGLTFNKK-EFENSYIFDINTID---------RIFYLVADSE 106

  Fly   591 PTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGS 655
            ..:::|:..|  |               |:|          .|
  Rat   107 EDMNKWVRCI--C---------------DIC----------GF---------------------- 122

  Fly   656 VSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKP------------N 708
                     |.|.....|..:|||..       ..||.|...|......|:|            :
  Rat   123 ---------NPTEEDPVRPLASSSQA-------PADSPFAINTAPASAHMEPSSVALPPSYQLIS 171

  Fly   709 LPLTTMTRQLKEVGE----ITICES-------AGGDASSPERSGT-----LTRRHSRRKSQESNG 757
            ||....|..|:|..:    :..|:|       |..|::.|..|.|     :........||..:|
  Rat   172 LPPHPDTLGLREDPQDYLLLINCQSKKPEPTRAHFDSAKPTSSETDCNDNVPSHKPPASSQGKHG 236

  Fly   758 -SGTLKRRPI---AVPVATVVK--------------QTEPMGSASSTSSSSN----STPTPTPSI 800
             :|..:::.:   ..|..|.|.              ...|..|.|||.:...    :||:.|.|:
  Rat   237 MNGFFQQQMVYDCPPPRVTSVSGESGLYNLPRSYSHDVLPKESPSSTEADGELYVFNTPSGTSSV 301

  Fly   801 CAK-----------PPPGDSASL-------MCSSTLSLDSLP--PPPPPPALDGSEDQDVYGSQL 845
            .|:           |.||::..:       ....:..||::|  |||.||....:.|:    |.:
  Rat   302 EAQMRHVSISYDIPPTPGNTYQVPRTFPEGTLGQSSKLDTIPDVPPPRPPKPHSTHDR----SPV 362

  Fly   846 SLASLP------------PP---PP------------------------------PED------- 858
            ....:|            ||   ||                              |.|
  Rat   363 ETCGVPRTASDTDSSYCIPPAGMPPSRSNTISTVDLNKLRKDAGSQDCYDIPRTFPSDRSSSLEG 427

  Fly   859 ---------VLAM----------NYA--EPSSPST--PTPMSTPMIMPNSNGSLPPAVPAKPMKP 900
                     |||.          ||.  .|:||..  |:..:.|:..||          ..||.|
  Rat   428 FHNQLKIKNVLAAGNVSGEELDENYVPMNPNSPPRHHPSSFAEPIQEPN----------YVPMTP 482

  Fly   901 AVKQ-AAGGLKAAPPYKAPPDYVG----PALLPGPPLP----PPPPAQKKVS---FADSPVLLR- 952
            .... :|.|::.     .||.::|    |...|..|:|    .|||..:.:.   ...||.:||
  Rat   483 GTFDFSAFGMQV-----PPPAHLGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRP 542

  Fly   953 ------------------RKMCSPEPV------------LPQRSPSTTL---------------S 972
                              |:...|.|:            .|.|||.|..               |
  Rat   543 KPHGLERTDSQTVGGFATRRKVKPAPLEIKPLSEWEELQAPVRSPITRSFARDSSRFPMSPRPDS 607

  Fly   973 CHSSSSAGSAY---QTYAP-GPMLPPRADVARLSSLSNGSSSEVTSPK----------RLQESAS 1023
            .||::|:..::   :.|.| .|.|.........::...|:||.:|.||          .|:...|
  Rat   608 VHSTTSSSDSHDSEENYVPMNPNLSNEDQNLFCNNSLEGASSPMTKPKGDKQVEYLDLDLESGKS 672

  Fly  1024 NPPR 1027
            .|||
  Rat   673 TPPR 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382
		PH_APBB1IP	489..614	CDD:269961	26/131 (20%)
		PH	494..605	CDD:278594	26/117 (22%)
Gab1	XP_038953748.1	PH-like	30..130	CDD:418428	31/169 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900