DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pico and Cobll1

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_006499773.1	Gene:	Cobll1 / 319876	MGIID:	2442894	Length:	1274	Species:	Mus musculus

Alignment Length:	1112	Identity:	216/1112 - (19%)
Similarity:	352/1112 - (31%)	Gaps:	328/1112 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GAAAG------------GATTTTTTTTAAGFVAGGDCPVIGAGAGAGVKLRRHSDRPLTPEAKQL 121
            |||.|            ....|..:::.|..|..|...:.....|.....|.....|..|....|
Mouse   350 GAAQGQERRASCVERSTSVDDTDKSSSEAIMVRTGSLQLSSTSIGTSSLKRTKRKAPAPPSKTPL 414

  Fly   122 SHT--YRISMAN---LEDSQESELDQILGELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVT 181
            :.|  ...:||:   |||....  |.:| |||..|. :|..|.|:.|...:....|...||..::
Mouse   415 AQTDERNSAMAHGLPLEDGIAP--DSML-ELSSPEG-MSTPEGSLGPGFLSQEQCAVPKPPDEIS 475

  Fly   182 QLPGSAPTMV-SMSASSSRSHSRTNSTISADVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPP 245
            :.||:....| |:::..|..:|........::|..|..                          |
Mouse   476 EGPGTPEAAVASLTSGVSSDYSLEEIDEKEELSEASKD--------------------------P 514

  Fly   246 PGGMTMGITLGVVTPREPRTESPDNDSAFSD-----------TVSLLSSESSASSNTSLQQQQQQ 299
            .|.:::              :|||..||.:|           .:.:...|:|.||....|:.:..
Mouse   515 AGSISV--------------KSPDIASASTDMRITVEKDPDSALGISDGETSPSSKGKTQEGRST 565

  Fly   300 QQQQHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLESAP 364
            :.|.                         .:|.|.|..|.:...::||  .|...|..:: ||..
Mouse   566 EGQG-------------------------PYHPVVGHIGNEDRVSDSI--KDMKTLGPNQ-ESVV 602

  Fly   365 IRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHEL 429
            ...:.|.|.::|      .|..|.|          |....::.....::...|::.:||......
Mouse   603 QNEIMVCATSTD------YVKNRPG----------KMETTIEGEGEALKKASDMETDRLSGSPAC 651

  Fly   430 LVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQTRQMLLDEFFDSHNQL 494
            .:||:   .|...|.:.....||:       :|..||.:...  ..|...:.......||.::::
Mouse   652 RMDNV---KSSRENHLTASPGPDQ-------KLNQPGVEKTK--MQDAAIQATPARGTFDGNHEV 704

  Fly   495 Q-------------MDGPLYMK------ADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLN 540
            .             .||.:..:      .|.....:.:    ||.|...:.:::... ::.||.
Mouse   705 SNSSDPRADETVQTSDGSISAQHSSASLQDSVNASREF----RSQGTSTYVQDRLPE-KEPACT- 763

  Fly   541 LFHGHNVYTGLGWRKKWKSPTD---------YTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRW 596
              :|:||..         ||.|         |...|......|..|. :....:..|.:|.:.
Mouse   764 --YGNNVPL---------SPVDGSNKNPAASYLKNFPLYRQDSNPKP-KPSNEITREYIPKIG-- 814

  Fly   597 LTAIRVCKYGKQL-----WDSHKSLLEDLCLSRDD-----AVSQSSFAASMRSESISSISSAVPS 651
            :|..::.. .|.|     |:|.       .:.|.|     .|.|.....:|..   :|:.:.||:
Mouse   815 MTTYKIVP-PKSLEMAKDWESE-------AMGRKDDQKMLPVGQRHTIENMTE---TSMQTEVPA 868

  Fly   652 QCGSVSSAISSMSNSTSGRTSR---ASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTT 713
            ...|.......:....|..|.|   .:.||.:|..::...|......||||...|:::
Mouse   869 TSKSSQQPQPDLKPKPSSGTERHLHRTLSSPTGTETNPPKAPRVTTDTGTIPFAPNLE------- 926

  Fly   714 MTRQLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVK--- 775
               .:..:.|......|....:.|.......::.:......|..:.::...|...|....:|
Mouse   927 ---DINNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHTAPGPAPKEPTIKEVQ 988

  Fly   776 ---QTEPMGSASSTSSSSNSTPTPTPS-----ICAKP----PPGDSASLMCSSTLSLDSLPPPPP 828
               |..|....||.|..::|.|.|..|     |..||    ||..:...|   ||..::.|||
Mouse   989 RDPQLSPEQHPSSLSERTHSAPLPNISKADDDIIQKPAETSPPPVAPKPM---TLRAETSPPP-- 1048

  Fly   829 PPALDGSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPSSPSTPTPMSTPMIMPN----SNGSL 889
                       |:...::|.:...|||         ..|...:.|...|.|::.|.    ...:.
Mouse  1049 -----------VFPKPMTLPAETSPPP---------VFPKPMTLPAETSLPLVFPKPMTLRAETS 1093

  Fly   890 PPAVPAKPMK-PAVKQAAGGLKAAPPYKAPPDYVGPALLPGPPLPPPPPAQKKVSFADSPVLLRR 953
            ||.|.|||:. |..:..:..||....:.||..|..    .||                ||..|
Mouse  1094 PPPVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSS----SGP----------------SPFAL-- 1136

  Fly   954 KMCSPEPVLPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADV-------------------- 998
                   .:.:||.|.:.:|..|:|.||:        .|||.|..
Mouse  1137 -------AVVKRSQSFSKACPESASEGSS--------ALPPAATQDEKTHTVNKPTVGSQHGDGD 1186

  Fly   999 ARLSSLSNGSSSEVTSP--------KRLQES---ASNPPRDFLKDLQRVMRKKWQVAQKCKAEPA 1052
            .:.:.:.|..||:|.:|        || |.|   .|:.|....:.|...:| ..:.|.|.|.  .
Mouse  1187 KQNNPVQNEHSSQVLTPADGPSFTLKR-QSSLTFQSSDPEHVRQSLLTAIR-SGEAAAKLKR--V 1247

  Fly  1053 TTPHEVL 1059
            |.|...:
Mouse  1248 TVPSNTI 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	14/86 (16%)
		PH_APBB1IP	489..614	CDD:269961	26/157 (17%)
		PH	494..605	CDD:278594	21/138 (15%)
Cobll1	XP_006499773.1	Cobl	176..252	CDD:312839
Cobll1	XP_006499773.1	PHA03247	<906..1177	CDD:223021	72/342 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900