DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pico and GRB14

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_004481.2	Gene:	GRB14 / 2888	HGNCID:	4565	Length:	540	Species:	Homo sapiens

Alignment Length:	342	Identity:	105/342 - (30%)
Similarity:	160/342 - (46%)	Gaps:	25/342 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 SITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWA 410
            |:..||....|..:      ::..:|.::.|..|::|.|...:....|.:||..|||.....:|.
Human    92 SVLSADLFPKANSR------KKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWT 150

  Fly   411 LVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQ- 474
            |.|||..:.:||..|||||:::.|..|..:..|::.|::...|...|..|..:.|...::...:
Human   151 LFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATET 215

  Fly   475 HDEQTRQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACL 539
            :.|.:...:|..|..|....::.|.|:.|...||.||:.:|.||.||||:..|..:|..|.|...
Human   216 NGEISPTQILQMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFF 280

  Fly   540 NLFHGHNVYTGLGWRKKWKSPTDYTFGF---KAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIR 601
            :.|...::|..|..:||..:||:|.|.|   ||.|.       |.|||||||:..:...|:||||
Human   281 SEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGGP-------RDLKMLCAEEEQSRTCWVTAIR 338

  Fly   602 VCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNS 666
            :.|||.||:.::....:    .|....|||  .:.||  |||..|.......|..|..|.:.:.:
Human   339 LLKYGMQLYQNYMHPYQ----GRSGCSSQS--ISPMR--SISENSLVAMDFSGQKSRVIENPTEA 395

  Fly   667 TSGRTSRASSSSSSGCL 683
            .|.......:....|||
Human   396 LSVAVEEGLAWRKKGCL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	27/86 (31%)
		PH_APBB1IP	489..614	CDD:269961	50/127 (39%)
		PH	494..605	CDD:278594	44/113 (39%)
GRB14	NP_004481.2	RA_GRB14	107..191	CDD:340556	27/83 (33%)
		PH_APBB1IP	230..351	CDD:269961	50/127 (39%)
		BPS	370..414	CDD:401046	11/43 (26%)
		SH2_Grb14	433..540	CDD:198277
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740