DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pico and GRB7

DIOPT Version :9

Sequence 1:NP_608363.1 Gene:pico / 33003 FlyBaseID:FBgn0261811 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_001229371.2 Gene:GRB7 / 2886 HGNCID:4567 Length:555 Species:Homo sapiens


Alignment Length:594 Identity:136/594 - (22%)
Similarity:206/594 - (34%) Gaps:162/594 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 YTEASMLPAMCAPSAGAQIAPPPGVTQLPGSAPTMVSMSASSSRSHSRTNSTISADVSSCSSSGI 220
            :|..|:.|..|:.:....::||              .:|:|..              ..|.:   
Human    10 HTTGSVKPLSCSDAMELDLSPP--------------HLSSSPE--------------DLCPA--- 43

  Fly   221 SENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREPRTESPDNDSAFSDTV------S 279
                         ||:        |||           |||.|.|..|:........:      .
Human    44 -------------PGT--------PPG-----------TPRPPDTPLPEEVKRSQPLLIPTTGRK 76

  Fly   280 LLSSESSASSNTSLQQQQQQQQQQHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGA 344
            |...|..|:|..|:.....:            ......|.|.|.|                .|.|
Human    77 LREEERRATSLPSIPNPFPE------------LCSPPSQSPILGG----------------PSSA 113

  Fly   345 NSITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNW 409
            ..:...|            ..|...||.::.|||.:|:.|.......||..:|..:.|......|
Human   114 RGLLPRD------------ASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETW 166

  Fly   410 ALVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLF------LRPELYLPGPQ 468
            .|||....|.:||..||||.:|:....|.....:|.:|::...|..||      |.||      :
Human   167 GLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPE------K 225

  Fly   469 MAPGC--QHDEQTRQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTK 531
            |...|  .|...:.:.|:..|.::.:..::.|.|.::...:|.|||:...||.|||||..|..:|
Human   226 MVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSK 290

  Fly   532 NTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRW 596
            :.|.|..:...:..|||.....||.:..|||  ||| .|..:.|....:.|::.|:||..:...|
Human   291 DPRHLQYVADVNESNVYVVTQGRKLYGMPTD--FGF-CVKPNKLRNGHKGLRIFCSEDEQSRTCW 352

  Fly   597 LTAIRVCKYGKQLWDSHKSL----LEDLCL-------SRDDAVSQSSF----------------- 633
            |.|.|:.|||.||:.:::..    |...||       :.|:.:....|                 
Human   353 LAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSV 417

  Fly   634 ----AASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEF 694
                |.:.|.::...:|..:|:...|:|:||........||.||..|....|    .....|..|
Human   418 ALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIG----QQGLVDGLF 478

  Fly   695 TTGTIKRKP 703
            .....:|.|
Human   479 LVRESQRNP 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
picoNP_608363.1 GRB7_RA 364..451 CDD:176382 27/86 (31%)
PH_APBB1IP 489..614 CDD:269961 43/124 (35%)
PH 494..605 CDD:278594 38/110 (35%)
GRB7NP_001229371.2 RA_GRB7 123..210 CDD:340557 27/86 (31%)
PH_APBB1IP 248..370 CDD:269961 43/124 (35%)
BPS 389..433 CDD:401046 4/43 (9%)
SH2_Grb7 448..555 CDD:198276 11/44 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157311
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3751
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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