Protein Alignment pico and GAB1

DIOPT Version :9

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_016863455.1
• Gene: GAB1 / 2549
• HGNCID: 4066
• Length: 738
• Species: Homo sapiens
• Alignment Length: 751
• Identity: 152/751 - (20%)
• Similarity: 223/751 - (29%)
• Gaps: 294/751 - (39%)

  Fly   500 LYMKADPKKGWKRYHFVLRSSG-------LYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKW 557
            ||.|   ||.|||..|||||..       |.|:..:..|....:..|||.  ..|..||.:.||
Human     6 LYKK---KKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLC--QQVDAGLTFNKK- 64

  Fly   558 KSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLC- 621
            :....|.|....:.         .:..|.|:....:::|:..|  |               |:|
Human    65 EFENSYIFDINTID---------RIFYLVADSEEEMNKWVRCI--C---------------DICG 103

  Fly   622 --LSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAI------------------------ 660
              .:.:|.|.....:....::...:|::|.||.....|||.
Human   104 FNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQ 168

  Fly   661 ---------SSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTR 716
                     |.....||..:|..|.......|.:|   |:|:              .:||.|...
Human   169 DYLLLINCQSKKPEPTSQGSSFVSEEGEEYLLLED---FESK--------------TIPLQTHAD 216

  Fly   717 QLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNG-SGTLKRR------PIAVPVATV- 773
            ..|.....|.|........:|            ..||..:| :|..:::      |...|.|:|
Human   217 SAKSTSSETDCNDNVPSHKNP------------ASSQSKHGMNGFFQQQMIYDSPPSRAPSASVD 269

  Fly   774 ----------VKQTEPMGSASSTSSSSN----STPTPTPSICAK-----------PPPGDSASL- 812
                      .....|..|.|||.:...    :||:.|.|:..:           |.||::..:
Human   270 SSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIP 334

  Fly   813 ------MCSSTLSLDSLP--PPPPPPALDGSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPS- 868
                  ....|..||::|  |||.||....:.|:    |.:...|:|......|   .:|..|:
Human   335 RTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDR----SPVETCSIPRTASDTD---SSYCIPTA 392

  Fly   869 --SPSTPTPMST------------------PMIMPNSN-------------------GSLPPA-- 892
              |||....:||                  |...|:..                   ||:...
Human   393 GMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEEL 457

  Fly   893 ----VPAKPMKPAVK---------QAAGGLKAAP------------PYKAPPDYVG----PALLP 928
                ||..|..|..:         |.|..:...|            |   ||.::|    |...|
Human   458 DENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVP---PPAHMGFRSSPKTPP 519

  Fly   929 GPPLP----PPPPAQKKVS---FADSPVLLR-------------------RKMCSPEPV------ 961
            ..|:|    .|||..:.:.   ...||.:||                   |:...|.|:
Human   520 RRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLP 584

  Fly   962 ------LPQRSPSTTL---------------SCHSSSSAGSAY---QTYAP-GPMLPPRADVARL 1001
                  .|.|||.|..               |.||::|:..::   :.|.| .|.|.........
Human   585 EWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFG 649

  Fly  1002 SSLSNGSSSEVTSPK----------RLQESASNPPR 1027
            |:..:|.||.:..||          .|....|.|||
Human   650 SNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPR 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382
		PH_APBB1IP	489..614	CDD:269961	31/120 (26%)
		PH	494..605	CDD:278594	31/111 (28%)
GAB1	XP_016863455.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900