Protein Alignment pico and COBLL1

DIOPT Version :9

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001265387.1
• Gene: COBLL1 / 22837
• HGNCID: 23571
• Length: 1233
• Species: Homo sapiens
• Alignment Length: 1159
• Identity: 215/1159 - (18%)
• Similarity: 353/1159 - (30%)
• Gaps: 411/1159 - (35%)

  Fly    76 TTTTTTTTAAGFVAG---GDCPVIGAGAGAGVKLRRHSDRPLTPEAKQLSHTYRISMANLEDSQE 137
            |.|.:.|.:..:::.   .|.|           .:|.:..|..|.::.:..       :|...||
Human   335 TFTRSNTISKPYISNTLPSDAP-----------KKRRAPLPPMPASQSVPQ-------DLAHIQE 381

  Fly   138 SELDQILGELSLLEAQISYTEAS-------MLPAMC------------APSAGAQIAPPPG---- 179
            .....|:..:|:.|...|..||.       .|.:|.            |||..::|.|...
Human   382 RPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENS 446

  Fly   180 -VTQL---PGSAPTMVSMSASSSRSHSRTNS--TISADVSS---CSSSGISENGHGLGLVLGGPG 235
             ||.|   .|..|.    |||.:.|....:|  |....:||   |::..:.|...    |...||
Human   447 RVTALQPVDGVPPD----SASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETS----VFECPG 503

  Fly   236 SAGMMVQPPPPGGMTMGI----TLGVVTPREPRTESP----DNDSAFSDTVSLLSSE-------- 284
            :....:.     .:|.||    :|..:..:|..:|.|    :|.|..|..:..:|::
Human   504 TPEAAIT-----SLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKND 563

  Fly   285 -----SSASSNTSLQQQQQQQQQQHHQHQQHHQ--HQQQQQKPQLAGAEKLHHHGVHGQHGGQQS 342
                 .:.|...|....:::|:.:....|:.|.  :.....|..:.....|...|.:.::..|
Human   564 PDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVVQ-- 626

  Fly   343 GANSI-----TKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVD---ERMGCGHV----TR 395
              |.|     ...|.::..:.|.|           ...:|.:|:..:|   ||......    |.
Human   627 --NEIIVYPENTEDNMKNGVKKTE-----------INVEGVAKNNNIDMEVERPSNSEAHETDTA 678

  Fly   396 LLADKNHVQMQS------NWALVEHLGDLQMERL---------FEDHEL-----------LVDNL 434
            :...:||:...|      |....|...|..::..         .:||.|           ..:|:
Human   679 ISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNI 743

  Fly   435 MTWHS-----DAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQTRQMLLDEFFDSHNQL 494
            .|.||     |:.|  ..::...:.||.:..|  .|.....|.|.|..       |:.....:::
Human   744 STQHSCLSSQDSVN--TSREFRSQGTLIIHSE--DPLTVKDPICAHGN-------DDLLPPVDRI 797

  Fly   495 QMDGPL-YMKADPKKGWKRYHFVLRSSGLY---YFPKEKTKN--TRDLACLNLFHGHNVY----- 548
            ..:... |:|..|               ||   |.||.|..|  ||:....   .|...|
Human   798 DKNSTASYLKNYP---------------LYRQDYNPKPKPSNEITREYIPK---IGMTTYKIVPP 844

  Fly   549 TGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSH 613
            ..|...|.|:|.|                    ::....:|:..|            ||:  .:|
Human   845 KSLEISKDWQSET--------------------IEYKDDQDMHAL------------GKK--HTH 875

  Fly   614 KSLLEDLCLSRDDAVSQS--------SFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGR 670
            :::.|....:.|.|:|:|        ....::|:|      ..|||   ||||...:|
Human   876 ENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTE------HQVPS---SVSSPDDAM------- 924

  Fly   671 TSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTRQLKEVGEITICESAGGDAS 735
                                     ...:|..|.|..:.........|:|:..|.
Human   925 -------------------------VSPLKPAPKMTRDTGTAPFAPNLEEINNIL---------- 954

  Fly   736 SPERSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQTEPMGS---ASSTSSSSNSTPTPT 797
                       .|:.||:.||..        |.|.:..::..:.:..   .|:.:.|.::.|.|.
Human   955 -----------ESKFKSRASNAQ--------AKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPA 1000

  Fly   798 PSICAK--------PPPGDSASLMCSSTLS-LDSLPPPPPPPALDGSEDQDVYGSQLSLASLPPP 853
            |.....        |.|        ..||| |..:|...|.|.::.::| ||.|...:.|| |||
Human  1001 PKELTNKEAERDMLPSP--------EQTLSPLSKMPHSVPQPLVEKTDD-DVIGQAPAEAS-PPP 1055

  Fly   854 --PPPEDVLAMNYA-------------EPSSPSTPTPMSTPMIMPNSNGSLPPAVPAKPMKPAVK 903
              |.|..:.|...:             .|.|.|.|:|.:..::  ..:.|........|...|:.
Human  1056 IAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVV--KRSQSFSKERTESPSASALV 1118

  Fly   904 QAAGGLKAAPPYKAPPDYVGPALLPGPPLPPPPPAQKKV----SFADSPVLLRRKMCSPEPVLPQ 964
            |                            ||....:.|.    .|.|.|.|
Human  1119 Q----------------------------PPANTEEGKTHSVNKFVDIPQL-------------- 1141

  Fly   965 RSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESASNPPRDF 1029
                 .:|...::||.:...:..|.|...|...|.|.|||:..||    .|:::::|.....|
Human  1142 -----GVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSS----DPEQMRQSLLTAIR-- 1195

  Fly  1030 LKDLQRVMRKKWQVAQKCKAEPATTPHEVLGFRDFSNEDLLAAHNLNSGANSSH 1083
                      ..:.|.|.|.  .|.|...:.....|.    .:|:::..|...|
Human  1196 ----------SGEAAAKLKR--VTIPSNTISVNGRSR----LSHSMSPDAQDGH 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	21/124 (17%)
		PH_APBB1IP	489..614	CDD:269961	23/135 (17%)
		PH	494..605	CDD:278594	21/121 (17%)
COBLL1	NP_001265387.1	UBQ	113..182	CDD:294102
		Cobl	197..275	CDD:286545

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900