DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pico and Y37D8A.4

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_499670.1	Gene:	Y37D8A.4 / 176699	WormBaseID:	WBGene00012546	Length:	227	Species:	Caenorhabditis elegans

Alignment Length:	180	Identity:	35/180 - (19%)
Similarity:	70/180 - (38%)	Gaps:	51/180 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   961 VLPQRSPSTTLSCH-----SSSSAGSAYQTYAPGPMLPPRADVA---RLSSLSNGSSSEVTS-PK 1016
            :||:|..|..|. |     ||..|...|::::.|.::.|....|   ....:..|::...:| |.
Worm     4 LLPRRRFSALLD-HIKNWTSSIRADKQYRSFSTGDLVSPSQPSAFEPDFMEMEFGATPTTSSLPS 67

  Fly  1017 RLQESASNPPRDFLKDLQRVMRKKWQVAQKCKAEPATTPHEVLGFRDFSN---EDLLAAHN---- 1074
            ...:: ...|.:|.|...:::.:..:.|:|.|        :...|.:.|.   ||:..|.:
Worm    68 HFDDN-DLVPVEFKKSGVKLIPQGTRKAEKAK--------KFGSFEELSKVKLEDIHRAQSWFFV 123

  Fly  1075 -----------LNSGANSSHY-------------YRETANVSHWVRKHYE 1100
                       :::|.:.|.:             :|:| .|.|.|.::|:
Worm   124 DVDPKSAERILMSNGFSDSSFLISFFRQKYVLSIWRKT-KVEHLVIRNYQ 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382
		PH_APBB1IP	489..614	CDD:269961
		PH	494..605	CDD:278594
Y37D8A.4	NP_499670.1	SH2	118..202	CDD:214585	8/56 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900