Protein Alignment pico and mig-10

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001367746.1
• Gene: mig-10 / 176168
• WormBaseID: WBGene00003243
• Length: 779
• Species: Caenorhabditis elegans
• Alignment Length: 817
• Identity: 227/817 - (27%)
• Similarity: 345/817 - (42%)
• Gaps: 243/817 - (29%)

  Fly   112 RPLTPEAKQLSHTYRISMANLEDSQESELDQILGELSLLEAQISYTEASMLPAMCAPSAGAQIAP 176
            ||..|....:. |.|.||.|:::|.:.:||::|.||..||.|::           :.:.|.|:.
 Worm   129 RPQVPPKPPID-TVRYSMNNIKESADWQLDELLEELEALETQLN-----------SSNGGDQLL- 180

  Fly   177 PPGVTQLPGSAPTMVSMSASSSRSHSRTNSTISADVSSCSSSGISENGHGLGLVLGGPGSAGMMV 241
             .||:.:|          |||||.:.::.||:
 Worm   181 -LGVSGIP----------ASSSRENVKSISTL--------------------------------- 201

  Fly   242 QPPPPGGMTMGITLGVVTPREPR---------------------------TESPDNDSAFSDTVS 279
             ||||..::..     .||::|:                           ..|||.||||.|:.|
 Worm   202 -PPPPPALSYH-----QTPQQPQLLHHHNNHLGYQNGIHQITSINSAASSCSSPDGDSAFGDSSS 260

  Fly   280 LLSS-----ESSASSNTSLQQQQQQQQQQHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGG 339
            ..||     .|:.|||.|.:...             :.....|..|:            :|:...
 Worm   261 TESSNNRCRNSAFSSNDSCRDSL-------------NTPSPTQVSPR------------NGELNA 300

  Fly   340 QQSGANSITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQ 404
            :::      ||.||:.||.|::.|.:.::|||.|..||.:..||:|||.......:.||:|||:.
 Worm   301 EEA------KAQKIRQALEKMKEAKVTKIFVKFFVEDGEALQLLIDERWTVADTLKQLAEKNHIA 359

  Fly   405 MQSNWALVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGP-- 467
            :..:..:||...:|.::|::||||.:|:|:..|..|:.|::.|.:||||.....||||||..|
 Worm   360 LMEDHCIVEEYPELYIKRVYEDHEKVVENIQMWVQDSPNKLYFMRRPDKYAFISRPELYLLTPKT 424

  Fly   468 ----QMAPGCQHDEQTRQMLLDEFFDSHNQ----LQMDGPLYMKADPKKGWKRYHFVLRSSGLYY 524
                ::..|.|.....:|..:.|:|  |.:    .:|:|.||:|:|.:|.||:::||||.|||||
 Worm   425 SDHMEIPSGDQWTIDVKQKFVSEYF--HREPVVPPEMEGFLYLKSDGRKSWKKHYFVLRPSGLYY 487

  Fly   525 FPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAED 589
            .||.|...|:||.||...|.:.||||:||.||:||||.:....|......  |..:.:|.:||||
 Worm   488 APKSKKPTTKDLTCLMNLHSNQVYTGIGWEKKYKSPTPWCISIKLTALQM--KRSQFIKYICAED 550

  Fly   590 LPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESI---SSISSAVPS 651
            ..|..:||.|:|:.|.|.:|.::::.                  |..:|.|::   ||:|:|
 Worm   551 EMTFKKWLVALRIAKNGAELLENYER------------------ACQIRRETLGPASSMSAA--- 594

  Fly   652 QCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDD--NNAFDSEFTTGTIKRKPSMKPNLPLTTM 714
               |.|:|||.:.:|.| ...|..|.:||..||..  ||                  |..||:..
 Worm   595 ---SSSTAISEVPHSLS-HHQRTPSVASSIQLSSHMMNN------------------PTHPLSVN 637

  Fly   715 TRQLKEVG-EITICESAGGDASSPER-SGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQT 777
            .|...... .:..|:.     |.|.| |..|..::      :...:||:||.|:     .|:::.
 Worm   638 VRNQSPASFSVNSCQQ-----SHPSRTSAKLEIQY------DEQPTGTIKRAPL-----DVLRRV 686

  Fly   778 EPMGSASST-----SSSSNSTPTPTP--SICAKPPPGDSASLMCSSTLSLDSLPPPPPPPALDGS 835
            ....::|.|     |.|....|.|.|  |:...|||               ..||.|..|
 Worm   687 SRASTSSPTIPQEESDSDEEFPAPPPVASVMRMPPP---------------VTPPKPCTP----- 731

  Fly   836 EDQDVYGSQLSLASLPPPPPP-EDVLAMNYAEPSSPS 871
                     |:....|||||. .|...:..|.|.:|:
 Worm   732 ---------LTSKKAPPPPPKRSDTTKLQSASPMAPA 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	30/84 (36%)
		PH_APBB1IP	489..614	CDD:269961	55/128 (43%)
mig-10	NP_001367746.1	Ubl1_cv_Nsp3_N-like	321..406	CDD:475130	30/84 (36%)
		PH_APBB1IP	452..575	CDD:269961	54/124 (44%)