Protein Alignment pico and Grb7

DIOPT Version :9

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_034476.1
• Gene: Grb7 / 14786
• MGIID: 102683
• Length: 535
• Species: Mus musculus
• Alignment Length: 507
• Identity: 125/507 - (24%)
• Similarity: 193/507 - (38%)
• Gaps: 120/507 - (23%)

  Fly   244 PPPGGMTMGITLGVVTPREPRTES------PDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQ 302
            ||||.:.....|.:.:.|:.|.|.      |...:.|.:..|
Mouse    34 PPPGDVKRSQPLPIPSSRKLREEEFQATSLPSIPNPFPELCS----------------------- 75

  Fly   303 QHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLESAPIRR 367
                        ...|||.|.|:                |||..:...|..:|.:
Mouse    76 ------------PPSQKPILGGS----------------SGARGLLPRDSSRLCV---------- 102

  Fly   368 LFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVD 432
              ||.::.|||.:|:.|.......||..:|..:.|.....:|.|||....|.:||..||||.:|:
Mouse   103 --VKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDESWGLVESHPYLALERGLEDHEFVVE 165

  Fly   433 NLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQT---RQMLLDEFFDSHNQL 494
            ....|.....:|.:|::...|..||..|...|...:|...|. |.||   .:.|:..|.::.:..
Mouse   166 VQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCL-DAQTGISHEDLIQNFLNAGSFP 229

  Fly   495 QMDGPLYM----KADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRK 555
            ::.|.|.:    :...:|.|||:...||.|||||..|..:|:.|.|..:...:..|||.....||
Mouse   230 EIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRK 294

  Fly   556 KWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSH------- 613
            .:..|||  ||| .|..:.|....:.|.:.|:||..:...||.|.|:.|||.||:.::
Mouse   295 LYGMPTD--FGF-CVKPNKLRNGHKGLHIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRH 356

  Fly   614 -----------KSLLEDLCLSRD-------------DAVSQS-SFAASMRSESISSISSAVPSQC 653
                       :|:.::..::.|             :|:|.: ..|.:.|.::...:|  :|:.|
Mouse   357 LRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIDNPREALSAAMEEAQAWRKKTNHRLS--LPTTC 419

  Fly   654 --GSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKP 703
              .|:|:||........||.||..|....|    .....|..|.....:|.|
Mouse   420 SGSSLSAAIHRTQPWFHGRISREESQRLIG----QQGLVDGVFLVRESQRNP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	26/86 (30%)
		PH_APBB1IP	489..614	CDD:269961	43/146 (29%)
		PH	494..605	CDD:278594	38/114 (33%)
Grb7	NP_034476.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		18/106 (17%)
		RA_GRB7	102..186	CDD:340557	26/95 (27%)
		PH_APBB1IP	224..350	CDD:269961	43/128 (34%)
		BPS	369..413	CDD:370203	6/43 (14%)
		SH2_Grb7	428..535	CDD:198276	11/44 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740