DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pico and GAB4

DIOPT Version :9

Sequence 1:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_016884064.1	Gene:	GAB4 / 128954	HGNCID:	18325	Length:	575	Species:	Homo sapiens

Alignment Length:	535	Identity:	105/535 - (19%)
Similarity:	183/535 - (34%)	Gaps:	154/535 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 KADPKK-----GWKRYHFVLR----SSG---LYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRK 555
            |:.|:|     .|::..|:||    ||.   |.|:..:.:|.......|||....:|...|.:.|
Human    48 KSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLNLCEQLDVDVTLNFNK 112

  Fly   556 KWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAI-RVCKYGKQ-----LWD--- 611
            | :....|.|..|.        |.|:. .|.||....::.|:.:| ::|.:.::     |.:
Human   113 K-EIQKGYMFDIKT--------SERTF-YLVAETREDMNEWVQSICQICGFRQEESTGFLGNISS 167

  Fly   612 --------------SHKSLLEDLCLSRDDAVS----------------QSSFAASMRSESISSIS 646
                          ||:.|.::...:.:..||                :|...||.|:|...|.|
Human   168 ASHGLCSSPAEPSCSHQHLPQEQEPTSEPPVSHCVPPTWPIPAPPGCLRSHQHASQRAEHARSAS 232

  Fly   647 SAVPSQCGSVSSAISSMSNSTS------------------------------GRTSR-----ASS 676
            .:..|:...:....::|.|...                              |.|.|     ||.
Human   233 FSQGSEAPFIMRRNTAMQNLAQHSGYSVDGVSGHIHGFHSLSKPSQHNAEFRGSTHRIPWSLASH 297

  Fly   677 SSSSGCLSD---DNNAFDSEFTT--GTIKRKPSMKPN------LPLTTMTRQLKEVGEITICESA 730
            ..:.|.|:.   ||.|...::|.  |....:|:...:      ||..|:         :.:.:|.
Human   298 GHTRGSLTGSEADNEASSGKYTQHGGGNASRPAESMHEGVCSFLPGRTL---------VGLSDSI 353

  Fly   731 GGDASS-PERSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQTEPMG------SASSTSS 788
            ..:.|. |...|:.|....::...:|.|        :.:||.:.:.:.:.:|      |.....|
Human   354 ASEGSCVPMNPGSPTLPAVKQAGDDSQG--------VCIPVGSCLVRFDLLGSPLTELSMHQDLS 410

  Fly   789 SSNSTPTPTPSICAKP-------PPGDSASLMCSSTLSLDSLPPPPPPPALDGSEDQDVYGSQLS 846
            ..:....|..:...||       ||    :|..:..::..|..||...|....|...|...||..
Human   411 QGHEVQLPPVNRSLKPNQKANPTPP----NLRNNRVINELSFKPPVTEPWSGTSHTFDSSSSQHP 471

  Fly   847 LASLPPPPPPEDVLAMNYAEPSSPSTPTPMS---TPMIMPNSNGSLP-PAVPAKPMKPAVKQAAG 907
            :::........:.....|..|.:|::..|:|   :....|.|.|::. .|:..:|.||::.....
Human   472 ISTQSITNTDSEDSGERYLFPQNPASAFPVSGGTSSSAPPRSTGNIHYAALDFQPSKPSIGSVTS 536

  Fly   908 GLKAAPPYKAPPDYV 922
            |.|.        |||
Human   537 GKKV--------DYV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382
		PH_APBB1IP	489..614	CDD:269961	32/145 (22%)
		PH	494..605	CDD:278594	30/114 (26%)
GAB4	XP_016884064.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900