Protein Alignment pico and pico

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_061497476.1
• Gene: pico / 1273266
• VectorBaseID: AGAMI1_014224
• Length: 1180
• Species: Anopheles gambiae
• Alignment Length: 1260
• Identity: 577/1260 - (45%)
• Similarity: 691/1260 - (54%)
• Gaps: 315/1260 - (25%)

  Fly    60 GAASSAGVAGAAAGGATTTTTTTTAAGFVAGGDCPVIGAGAGAGVKLRRHSDRPLTPEAKQLSHT 124
            |:...:|..|.....|..|.||....                          ||.:..:.:.:.:
Mosquito    24 GSFDISGTPGTTVNPAAATVTTAARL--------------------------RPKSNTSAERTDS 62

  Fly   125 YRISMANLEDSQESELDQILGELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSAPT 189
            ||.||||||::||:|||.||||||:||.:
Mosquito    63 YRFSMANLEETQEAELDAILGELSILEER------------------------------------ 91

  Fly   190 MVSMSASSSRSHSRTNSTISA-------DVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPG 247
               ......||||||||||||       ..|.|||.....      :..||..::||      .|
Mosquito    92 ---GDLRHGRSHSRTNSTISAATNTTLSSESGCSSVAADT------VCSGGSIASGM------GG 141

  Fly   248 GMTMGITLGVVTPREPRTESPDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQQHHQHQQHHQ 312
            |:..|   .:...|||||:||||||||||||||:||||||||:.|            |.|.:|.|
Mosquito   142 GVGGG---NISLHREPRTDSPDNDSAFSDTVSLMSSESSASSSVS------------HSHLKHLQ 191

  Fly   313 HQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSIT------KADKIQLALHKLESAPIRRLFVK 371
                   ...|.:..:..:.|.....||..|.|:..      |..||.|||.|||.|.:||||||
Mosquito   192 -------AAAAASGGMVANSVPTALSGQTIGTNNNNNQPDGGKQAKIHLALQKLEQASVRRLFVK 249

  Fly   372 AFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNLMT 436
            |||:|||||||||||.|.||||||||||||||||:..||:||||.:.||||||||||:||||||.
Mosquito   250 AFTADGASKSLLVDETMSCGHVTRLLADKNHVQMEPTWAIVEHLPEHQMERLFEDHEMLVDNLML 314

  Fly   437 WHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQTRQMLLDEFFDSHNQLQMDGPLY 501
            |:.|:.|||||.||||||.||..||.:|||.|||||.:|||.||.|||||||:|.:|:.::||||
Mosquito   315 WNRDSKNRVLFLQRPDKVALFKTPEAFLPGTQMAPGSEHDEHTRTMLLDEFFNSGSQIALEGPLY 379

  Fly   502 MKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFG 566
            ||.|.|||||:||||||:|||:|:|||||::.:||.||.||.||.||.||||:||.|:|:||||.
Mosquito   380 MKNDAKKGWKKYHFVLRASGLHYYPKEKTRSAKDLLCLALFAGHEVYRGLGWKKKHKAPSDYTFA 444

  Fly   567 FKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQS 631
            .:.....:..|..||:|||||||..|::.|:|||||.||||:|.|:|::||:||.....|.:|
Mosquito   445 LRCPKLPAGVKGIRSVKMLCAEDASTMENWITAIRVMKYGKKLLDNHRTLLDDLARDELDKLS-- 507

  Fly   632 SFAASMRSESISSISSAVPSQCGSVSSAISSMSNST---------------------SGRTSRAS 675
                |.||.||.||.|:||||| |..|:.||.|.|.                     :||.||||
Mosquito   508 ----SARSSSIGSIVSSVPSQC-STGSSNSSGSGSNHLLVPLSATNGSNANNCTANGNGRLSRAS 567

  Fly   676 SSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTRQLKEVGEITICESAGGDASSPE-- 738
            ||||||||||:||.|||||.|||||||||||||||||:||||||||||.|..:.:.|...|..
Mosquito   568 SSSSSGCLSDENNGFDSEFPTGTIKRKPSMKPNLPLTSMTRQLKEVGETTRLKDSPGSVGSGSIG 632

  Fly   739 RSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQTEPMGSASSTSSSSNSTPTP------- 796
            ..||||||||||:|:||.|||||||||:         .|:..||..|.|||: |||||
Mosquito   633 EGGTLTRRHSRRRSEESTGSGTLKRRPM---------PTQNRGSIESMSSSA-STPTPVGSVLNT 687

  Fly   797 ------------------------------------------------TPSICAKPPP-----GD 808
                                                            |.|..:.|||     ||
Mosquito   688 PVNFEPPPVTILSPLGGHPTIVTPNGGNGGGNVPGTTTTIIEPVPSCMTDSTFSLPPPPPPPVGD 752

  Fly   809 S--ASLMCSSTLSLDSLPPPPPPPALDGSEDQDVYGSQLSLAS--LPPPPPPEDVLAMNYAEP-S 868
            .  .:....||||||||||||||..||.|    ..||||||||  |||||||...:....|.| :
Mosquito   753 DPMGANFSGSTLSLDSLPPPPPPNELDNS----FSGSQLSLASVQLPPPPPPSAAVGGATAAPAA 813

  Fly   869 SPSTPTPM-STPM--------------IMPN--------SNGSLPPAVPA-----------KPMK 899
            |||.||.: |:|.              :||:        ::.:||...||           |.:|
Mosquito   814 SPSMPTAVQSSPAARADSLQEKRPAANVMPSVAQSIMKLNSHTLPNPAPASAILKKEPIYSKTLK 878

  Fly   900 PAVKQAAGGLKAAPPYKAPPDYVG--PALLPGPPLPPPPPAQ-KKVSFADSPVLLRRKMCSPEPV 961
            |:      .|| ||||||||.|.|  .....|..:..||||. |.||||:||||||||:|..:.|
Mosquito   879 PS------ALK-APPYKAPPPYNGGEGGSASGAEVATPPPASAKSVSFAESPVLLRRKVCFEDEV 936

  Fly   962 LPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESASNPP 1026
            :.|..|.:.....:|.|.|      .|.|  ||||:..||       |:..||||||.||::|||
Mosquito   937 VVQEVPPSPRRICASYSVG------PPAP--PPRAEATRL-------STTYTSPKRLSESSANPP 986

  Fly  1027 RDFLKDLQRVMRKKWQVAQKCKAEPATTPHEVLGFRDFSNEDLLAAHNLNSG----ANSSHYYRE 1087
            |||||||||||.||||||||||.||||||||||||||.        |...:|    ::::.||||
Mosquito   987 RDFLKDLQRVMNKKWQVAQKCKLEPATTPHEVLGFRDI--------HGGGAGSDLYSSATPYYRE 1043

  Fly  1088 TANVSHWVRKHYEYAHNALYENVHAQ----------SAAAAGVPGSGEATTPPLPPPPGNSV--- 1139
            |||||:||::||..|.:.||||:.:.          :|..:.||..     |.|||..|..:
Mosquito  1044 TANVSNWVQEHYGAAPDGLYENLGSNMGMEPNYPIVAANVSAVPAH-----PHLPPTAGGPMLQG 1103

  Fly  1140 -----AAKKRPPPPPPKRSDKTHLT 1159
                 :.||||||||||||:||.||
Mosquito  1104 GGGGGSIKKRPPPPPPKRSEKTQLT 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	67/84 (80%)
		PH_APBB1IP	489..614	CDD:269961	74/124 (60%)
pico	XP_061497476.1	None