Protein Alignment pico and grb10

DIOPT Version :10

• Sequence 1: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_012819769.1
• Gene: grb10 / 100151701
• XenbaseID: XB-GENE-485564
• Length: 591
• Species: Xenopus tropicalis
• Alignment Length: 530
• Identity: 131/530 - (24%)
• Similarity: 221/530 - (41%)
• Gaps: 89/530 - (16%)

  Fly   267 SPDNDSAFSDTV--------SLLSSESSASSNTSLQQQQQQQQQQ------HHQHQQHHQHQQQQ 317
            :||:|......|        :|.|:.:|.|.:..|.:..|..:.|      :......|:.:.|:
 Frog    43 NPDDDVDLEALVNDMNSSLDNLYSTCTSVSESVPLLKNGQLNRSQLPNSGTNSLPSMPHKQKLQR 107

  Fly   318 QKPQLAGAEKLHHHGVHGQHGGQQSGANSI-----------TKADKIQLALHKL-ESAPI-RRLF 369
            .:|       :|.|.|. :...:|...:|:           |.|....|....| ::.|: ::..
 Frog   108 SQP-------MHIHAVR-RLQEEQLRTSSLPAIPNPFPELCTPASSPVLVPGSLPQNQPVGKKSV 164

  Fly   370 VKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELL--VD 432
            ||.|:.||.||.:.:...|......:||..::|....::|.||||...|.:||..||||::  |.
 Frog   165 VKVFSEDGTSKVVEILADMTARDFCQLLVYQSHCVDDNSWTLVEHHPHLGLERCLEDHEMVVHVQ 229

  Fly   433 NLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQT--RQMLLDEFFDSHNQLQ 495
            ::|:..|    :.||::...|...|..|..:.| .||...||....:  :..||..|.::::..:
 Frog   230 SMMSSES----KFLFRKNYAKYEFFKNPVNFFP-EQMVAWCQQSNGSIPQSQLLQNFLNANSCPE 289

  Fly   496 MDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKSP 560
            :.|.||:|...||.||:....||.||||...|..:|..|.|..::.....|:|:.:..:|.:.:|
 Frog   290 IQGFLYVKEVGKKSWKKLFVCLRRSGLYCSTKGMSKEPRHLQGISDLEDSNIYSLISCKKLYNAP 354

  Fly   561 TDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSH------------ 613
            ||  ||| .|..:.:....:.|:.|||||..:...|:||.|:.|||..|:.::
 Frog   355 TD--FGF-CVKPNKVRNEVKELRFLCAEDEQSRTCWMTAFRLLKYGMLLYQNYRIPQQKKSLHTN 416

  Fly   614 -----KSLLEDLCLSRD----------------DAVSQSSFAASMRSESISSISSAVPSQCGSVS 657
                 :|:.|:..::.|                .|..:...|...||..::.:.|..|....::|
 Frog   417 FSTPVRSVSENSLVAMDFSGQTGRVIENPVEAQSAAMEEGHAWRKRSSRLNVLGSQSPLHPSTLS 481

  Fly   658 SAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTRQLK-EV 721
            :.|....:...||.||..|.:    :.......|..|    :.|.....|...:.|:....| :.
 Frog   482 TVIHRTQHWFHGRISREESQT----IIKQQGLVDGLF----LLRDSQSNPKAFVLTLCHHQKIKH 538

  Fly   722 GEITICESAG 731
            .:|..||..|
 Frog   539 FQILPCEDDG 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	28/86 (33%)
		PH_APBB1IP	489..614	CDD:269961	42/141 (30%)
grb10	XP_012819769.1	RA_GRB10	161..252	CDD:340558	30/94 (32%)
		PH_APBB1IP	283..405	CDD:269961	42/124 (34%)
		BPS	422..465	CDD:462644	7/42 (17%)
		SH2_Grb10	484..591	CDD:198278	16/73 (22%)