Protein Alignment Nup205 and NUP192

DIOPT Version :9

• Sequence 1: NP_728308.1
• Gene: Nup205 / 33002
• FlyBaseID: FBgn0031078
• Length: 2090
• Species: Drosophila melanogaster
• Sequence 2: NP_012495.1
• Gene: NUP192 / 853410
• SGDID: S000003576
• Length: 1683
• Species: Saccharomyces cerevisiae
• Alignment Length: 2125
• Identity: 384/2125 - (18%)
• Similarity: 685/2125 - (32%)
• Gaps: 755/2125 - (35%)

  Fly    32 WT--PYKHLYNTFQTAVSNRSG-FTSDLEQCLKKYKHNFSNLLRNPPRSEKSRNLLRNALNEGVP 93
            |:  |::.||.:.:      || |..||   .|:...:..||..|..:.:  .|..|:.|.:|..
Yeast     3 WSAIPFQTLYRSIE------SGEFDFDL---FKEVLPDLQNLNLNTDKLK--NNASRSQLEKGEI 56

  Fly    94 MQGHSRKTKMSQDLADEAVILSDMFDLDEGFAVELLCTAQRQQKHHPGLSRGLVAVLLYYDGRKA 158
            ........|::|:...||:.|||..:|||..|.||:.:....      .:.|.|.   |:..|:.
Yeast    57 ELSDGSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTT------ANNGKVQ---YFLRRQY 112

  Fly   159 ISCTLRDMFQVVSGV----SWNTELPKEITGLVTNYAESLVDGSGILGRL----LQLLE-EMDVD 214
            |       .|:||.:    ..:|||.:|   |:.|.|  ||  |.||...    .||.| :..::
Yeast   113 I-------LQIVSFIVNCFHEDTELYQE---LIKNGA--LV--SNILSAFKFIHTQLSEIKQQIN 163

  Fly   215 KECAMLTTNRAF--GSKKHQNQVLGLYEDIQQALAMALFNWSAQRGLPRHIAIRLMHQLANRKNH 277
            |...:...|..|  ..|..::.:|..|:.:.|.|...:...:..:.  :...:.|:|.::...::
Yeast   164 KAQILENYNALFQQNIKFRRDFLLREYDILSQILYGLVDKGAIMKN--KDFILSLLHHVSELDSN 226

  Fly   278 DAGGNMDDVTLIMLMALLYAYDTSMLLVTEEPNEHTTRLPIFSDREFAECFLEELYAQSSWQAPR 342
            |        ..|:.....:.:..:.|.|          ||....:.....|:::|...|.:..|.
Yeast   227 D--------FFIIYYTPAFFHLFASLRV----------LPDADVKLLHSQFMKDLKDDSIYTKPV 273

  Fly   343 LNAIIAYSFGLTLASLRHAPLQLQATAISIINRDEMLIDEA-LGA--QVFVF-FHSLLLEKDLVY 403
            ..|:|...|...:...:..|.:...|.....:.||.:.... |||  |:.:| ..:.::|:|  .
Yeast   274 KVALIFIFFAYFIGWCKEDPKRRADTMDFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQD--K 336

  Fly   404 STQFFYRRVHLLITDFIDFMNSKVSELRGRADESSHTIISFLNEGLEPPPNLDSNFELLMLCVAK 468
            |.:.||        |....:...:..|..:.......|.|........|.:...|
Yeast   337 SMELFY--------DIRSLLERHIPRLIPKQLLDDEKIFSQTTNSTYNPASATDN---------- 383

  Fly   469 MHGDPRVTIRLCNEYWGPGDP-----NGSTAFKNTSRSVSLFK-------------FISLASDLL 515
            |.|         ...|.|..|     .|:....:...:|:.:.             |:|...|:|
Yeast   384 MSG---------RGLWNPSYPGMMSTTGTARLNSMPNNVNEYSYTTIVLSDQTQEFFLSSFDDVL 439

  Fly   516 PQTLFK--AYL----------KMISG--LTRTDFS------------------------------ 536
             ||:..  |:|          .::||  ||..|.|
Yeast   440 -QTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISLKADLERFFLSIYFFYASRPEYSCTFWSDK 503

  Fly   537 -----------ARCAFNMLRV------------PQMAT------GGKYAVSWDHFFTTLGNYYTS 572
                       :||..|::|.            |:.|.      |...::||.:....|.: ||.
Yeast   504 ESNAYGFIEWCSRCNDNLMRSCFYLMVSSLSFGPENALNVYHYFGENSSISWKNIAQCLSD-YTK 567

  Fly   573 MRNDFNTNI----GMSGETIYRTRSTPKAITQ---REA----EHLVAVMGIIQAVAEHD---EVS 623
            ..::||:::    ..|..|.....||..|:.:   .||    ..|:.::|.:....:.|   .:|
Yeast   568 KISNFNSSLHKRQQFSESTHNDIDSTAVALEEGLNEEAVIFLSSLLTLVGSVTYQVDEDVKSSLS 632

  Fly   624 RIMICDHPNWQTPQVLLGLVACATPLFLKA-EILHTLAALAKSKETARVIWFHLEASQIIPTVPV 687
            ::.         ..||.......|||...| :::..|....:|..|.  .|..|:
Yeast   633 KVF---------SDVLFEFTKINTPLVGAAFKVISNLVPKLESSRTK--FWSFLD---------- 676

  Fly   688 SRSYAQCSLLEEMEQIESRSEQYN------LTR-----GILQLLYTLMTTN-------------- 727
                   ||:.:...:...||.|.      ||:     |.|||.:.|::.:
Yeast   677 -------SLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIHSRENNSEYMVFGKL 734

  Fly   728 -LPKSLGAGQRTPAYEGYLKSMINSVLLKF-------YNRAYKVPSEKWQVGAQCLKLLYYLLAT 784
             .|..||.|.|......|...:.|.:|...       ..||.::|         .||::|..|.:
Yeast   735 AFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLP---------ILKIIYTGLCS 790

  Fly   785 YRPSAM-----------------DFLETVDE-PPYPGFHVMM-----------------QLQL-- 812
            :..|.:                 :|...|.| |..|.|:.:.                 ||.:
Yeast   791 FDYSVILNSIPAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSIFNVVDVGVDQLSIEL 855

  Fly   813 -----KSEMLQLLLCIVEEVRERLDNY-------NRFQGKK---LLEECSLYALLILEAALAKQN 862
                 ::|:|||.:.|:.:|.:..:.|       .:..||.   |.:..||:.|          .
Yeast   856 EGGKNQAELLQLAVKIINKVLDYQETYVEELFPIVKKHGKTDYFLPKNYSLHGL----------R 910

  Fly   863 AFFEAHSAANCPI-----LLSGLNRMLLDLNPRSRKPDHVLNIIKYVTYNSWLPRHALAAIKILA 922
            :|::| ...|.|:     |..|::..:|..|                            :::|||
Yeast   911 SFYDA-IFFNIPLVAHLGLYVGVDDQILATN----------------------------SLRILA 946

  Fly   923 SVTQLPNVSTQILSMYGQ------GSNEKLEIRQGFVECLEMEVCVGKHDDDLLDQLALNNHVPY 981
            .:::..|.|...||...:      ..:|...|:..|:
Yeast   947 KLSERSNGSVASLSKRNKLLTIFDSVDESARIKDAFI---------------------------- 983

  Fly   982 LGFGDDLDNEREMSGEREYSTIESQLELQAGDGALESKPASIELQLKEAIIKLFEMNLS--QQLP 1044
                                   :|||....|..:        |.||..::.....|||  .:..
Yeast   984 -----------------------TQLESSITDAGV--------LALKLELLDFLTSNLSNYSRTM 1017

  Fly  1045 NFVYFLLGVDV---------LREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSDKYCEHT 1100
            ...:.|||..|         |..|:::|         :|.::|::.:||..::... .|......
Yeast  1018 TISHLLLGFQVSNVISLGPNLATFISSG---------TSLLDSLISVLEASLNSIT-KDNIDYAP 1072

  Fly  1101 ARIVERIYHLFHGLCANRRTAETILRYFRLTCSDFLLRHLRSLPFRQHREDHVLHAMGHLLNCVS 1165
            .|:......:...||.|..|:..:..|  |...:|..|.:...|
Yeast  1073 MRLATAALEIILKLCRNPLTSGLLYSY--LIKENFFERIMILDP--------------------- 1114

  Fly  1166 IDVKLAAKHGQMTRFNQMCDILLIGNGMERSSHGLSMELGHSLISQPSSSFLAMDVLPAGGSISA 1230
                      |:|||...     .|:..:.|:            .:...:|:..:  ..|..:|.
Yeast  1115 ----------QVTRFTTW-----NGSPFDNST------------EEKCKNFIESE--SVGAFLSF 1150

  Fly  1231 VAHG----------AGSASLGAPNTGVKSLKPSLLQETSQGLHVTRLLDILVLEAGTLSQPQ--- 1282
            :|:.          ....|.....:.|.:....|:..|...:.:...||  .|..|.:.:|:
Yeast  1151 LAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLD--PLNYGNICEPKETL 1213

  Fly  1283 ---------LE-----------FFDGHLITQLLRDCEASAEAGANSRANLINVRKLYYILTDELY 1327
                     ||           .:|.|.:..|:|..:.......:|.:..:.|.|       |.:
Yeast  1214 SIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSNSFSLTVSK-------EQF 1271

  Fly  1328 MVQSIIASGQRKAISTEIMLLLNHAVNINRVRTQRCATLAFMAAWGQLVQVLFSNMPDAVLPATQ 1392
            :..:.:...:.|:..|.| :..|.|:.:|         |:.:.:|.||||::   :.|..|..:.
Yeast  1272 LKDADVECIKAKSHFTNI-ISRNKALELN---------LSVLHSWVQLVQII---VTDGKLEPST 1323

  Fly  1393 RRQHIIDIVEKVLIKVQPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDLAAEDSLSNGN 1457
            |...|:::...::.|   |...||.::..||. |:.||...:..|..:
Yeast  1324 RSNFILEVFGTIIPK---ISDYIEFNITFSEE-LVSLAVFLFDIYNRD----------------- 1367

  Fly  1458 GNAIGNDSQVNALCLGQRAIGTGSDGGSGGGRDIGSGGNSSNLRFILKNLVQWIMISEVKSQKLR 1522
                            ::.|   :|.|:..||          |..:.|..:|.|. |.:.|..||
Yeast  1368 ----------------RKLI---TDKGTVDGR----------LYQLFKTCIQGIN-SPLSSVALR 1402

  Fly  1523 INLYSSLLNCLRIAKRLRTDEHLEYQETLISRQESARTYNKEQRRDDRLRLKAMAAEVIGTFGEK 1587
            .:.|            :..:.:|       ||..|.:..:::..:|.||..|            |
Yeast  1403 SDFY------------ILANHYL-------SRVLSDQVGSEKVLQDLRLGSK------------K 1436

  Fly  1588 LIDTICHDAVTGHDVCRMLALACLDMISELQAVSTLCDFVASRGYLKHILESLDQSSTALC---- 1648
            |::.|.:|.|.|....|:..:..||.:.:|          |:|.....||:||.:::..|.
Yeast  1437 LVEIIWNDVVYGEGTSRVTGILLLDSLIQL----------ANRSKENFILDSLMKTTRLLLIIRS 1491

  Fly  1649 -----GILQPVPDH------LRPLYVYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQ 1702
                 .:|....:|      |..|..:::.:.||.|:|.:..||..|:......:::.:......
Yeast  1492 LKNTDALLNSTTEHINIDDLLYELTAFKATVFFLIRVAETRGGASALIENNLFRIIAELSFLKVD 1556

  Fly  1703 PDL-----------KSSELNRNEPQTFLPSIDDR------FRSILLPALSLCDAIVNSLGPRNNS 1750
            |||           ::|:..:.......|.:.|:      ...:::|...|..|::.|:| .:|.
Yeast  1557 PDLGLDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISAVLVSMG-SSNK 1620

  Fly  1751 AAVQVLNFLFAHIDMVEAMLRSATPYMDLGHLQQVAVISNLFARASTHELTALEDSVQLDLRNRL 1815
            |.||.:..|                                                       |
Yeast  1621 AVVQTVKGL-------------------------------------------------------L 1630

  Fly  1816 GRVQQLMIVVFGRFCVSEPTIRRMLQQDEEQQTNPTDDSKRLRVK 1860
            ...::|:|.:|.|..:.|       ::|::..::|.:.|....||
Yeast  1631 NTYKRLVIGIFKRDLLRE-------KEDKKNSSDPNNQSLNEMVK 1668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup205	NP_728308.1	Nup192	32..1796	CDD:314723	373/2059 (18%)
NUP192	NP_012495.1	Nup192	134..1677	CDD:403188	342/1964 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1835
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004958
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103030
Panther	1	1.100	-	-	LDO	PTHR31344
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3859
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930