Protein Alignment Nup205 and nup186

DIOPT Version :9

• Sequence 1: NP_728308.1
• Gene: Nup205 / 33002
• FlyBaseID: FBgn0031078
• Length: 2090
• Species: Drosophila melanogaster
• Sequence 2: NP_588399.1
• Gene: nup186 / 2538754
• PomBaseID: SPCC290.03c
• Length: 1647
• Species: Schizosaccharomyces pombe
• Alignment Length: 1946
• Identity: 356/1946 - (18%)
• Similarity: 622/1946 - (31%)
• Gaps: 672/1946 - (34%)

  Fly    30 DMW-----TPYKHLYNTFQTAVSNRSGFTSDLEQCLKKYKHNFSNLLRNPPRSEKSRNLLRNALN 89
            |:|     :...:|....::..||.:..:..|.|||:.|..:|...|...|.:..||..|.:...
pombe     2 DVWESQHFSALLYLLQCIESNPSNPNVSSRLLIQCLESYSKDFLKFLALDPANANSRKKLESGEV 66

  Fly    90 E--GVPMQGHSRKTKMSQDLADEAVILSDMFDLDEGFAVELLCTAQRQQKHHPGLSRGLVAVLLY 152
            |  ||       ..|:::.....::.||...:|||.....||   ||..:....|.|..|...||
pombe    67 ELGGV-------INKVNEQFIQLSLTLSTQLNLDEIQCASLL---QRGIEASQNLDRTPVQAALY 121

  Fly   153 YD--GRKAISCTLRDMFQVVSGVSWNTELPKEITGLVTNYAESLVD-GSGILGRLLQLLEEMDVD 214
            :.  .|:.:...|..:.:|| |:.   :|..:|:..:.:|.:||.: |:.::...:..:..:  |
pombe   122 FFFLAREQLLECLESLTRVV-GLK---DLESDISTALKSYLQSLCENGNNLVKTCIDTIPIL--D 180

  Fly   215 KECAMLTTNRAFGSKKHQNQVLGLYE--DIQQALAMALFNWSAQRGLPRHIA-----IRLMHQLA 272
            .:.:.:..:.|.|      |:||:.|  |.|:.:.::         ...|:|     ..:::|||
pombe   181 NKVSEILKSEAGG------QILGVSEVVDFQEFIRLS---------HEAHVAELETISVILYQLA 230

  Fly   273 N----------------RKNHDAGGNMDDVTLIMLMALLYAYDTSMLLVTEEPNEHTTRLPIFSD 321
            .                ||......|     .::::..|||:...:|.|...|::....
pombe   231 KVDLFQNSHFESLLVMLRKYDSPNKN-----AVLILPTLYAFIDKVLEVEYLPDQKVQL------ 284

  Fly   322 REFAECFLEELYA----------QSS--------WQAPRLNA----------------------- 345
            |..:...|::::.          :||        |...||||
pombe   285 RSNSVEILQKIHQAIIQSPSQDWRSSQFKNILGIWWVTRLNATCKQIEKVPSFIDYETTIKNAAN 349

  Fly   346 -------------IIAYSFGLTLASLRHAPLQLQATAISIINRDEMLIDEAL------------- 384
                         ::.|.|       |.:..:....|.:..:|..:.::.:|
pombe   350 EIIQNGVFSDMITLLVYPF-------RQSETEGMEWAFAFKSRSRITVNWSLIRPFIASIIFSEL 407

  Fly   385 --GAQVFVFFHS------LLLEKD-----LVYSTQ---------FFYRRVHLLITDFIDFMNSKV 427
              .||.||.:..      .|||:|     ..|.|.         |.:...:.|::....:..|.:
pombe   408 RSFAQAFVSYMPDILKTLRLLEEDRYLTNTTYPTSIPGEQIEEYFPFEEFYYLLSSIYTYNVSWI 472

  Fly   428 SELRGRADESSHTIISFLNEGL-EPPPNLDSNFELLMLCVAKMHGDPRVTIRLCNEYWGPGDPNG 491
            |:.   .|:....:..||...: ...|.:.:.|.||:             ..||
pombe   473 SDF---WDDIESDMYGFLTWSMGSQIPGIITAFTLLL-------------ASLC----------- 510

  Fly   492 STAFKNTSRSVSLFKFISLASDLLPQTLFKAYLKMISGLTRTDFSARCAFNMLRVPQMATGGKYA 556
                |||:   |..|...|.|:.:|:.   .:|:.:               |:..|
pombe   511 ----KNTT---SASKIYELFSEPIPEV---GHLESL---------------MITSP--------- 541

  Fly   557 VSWDHFFTTLGNYYTSMRNDFNTNIGMSGETIYRTRSTPKAITQREAEHLVAVMGIIQAVAEHDE 621
             ||.:.|... .||.|......|.:..||  :.|..:.|..|....|..|.|.:.:..:|...|.
pombe   542 -SWSYIFNVF-RYYISHLKPVQTVVTSSG--LARVHTDPSEIDTDSALILQAYILLFSSVVRQDA 602

  Fly   622 VSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHTLAALA--KSKETARVIWFHLE------- 677
            ......|::.:......|..|:.|..|..::..|:..|.:||  .:......:|..|:
pombe   603 QIASTFCENQDLNPIATLFELLECRLPDSVRICIVRALESLAHLSTGSFNNALWTALDNWFVSSV 667

  Fly   678 --------ASQIIPTV---PVSRSYAQCS-LLEEMEQIESRSEQ--------YNLTRGILQLLYT 722
                    |...||.:   .:::....|. ||..:.::....|.        .:|||...:|...
pombe   668 LFDVDGGLAPMSIPAISKRSLTKPVTSCGPLLNNIRRLTVNLEMKISFVNLLTSLTRNKSELNVN 732

  Fly   723 LMTTNLPKSLGAGQRTPAYEGYLKSMINSVLLKFYNRAYKVPSEKWQ----VGAQCLKLLYYLLA 783
            |   ..|::|||..|||..:.|:..::.:         :...|.:|:    ||:  ::|.|..|
pombe   733 L---TFPENLGASYRTPGVQPYVDYVVET---------FVASSTQWRLMRDVGS--IRLQYACL- 782

  Fly   784 TYRPSAMDFLETVDEPPYPGFHVMMQLQLKSEMLQLLLCIVEEVRERLDNYN------RFQGKKL 842
            .|..:.:|.|.             :.|.|.|.:|.      .:||:.|.|.|      |.....|
pombe   783 QYMLAVLDGLN-------------IDLLLYSRILS------SKVRDNLQNNNLHVYLTRHPAISL 828

  Fly   843 LEEC---SLY-----------------------------ALLILEAALAKQNAFFEAHSAAN-CP 874
            ||..   |:|                             :|.||...|:.|...|:     | .|
pombe   829 LEALYTESVYSGLFDLVEYGFDQLEDVSVPKTIVITVSASLCILRNVLSLQRVLFK-----NVVP 888

  Fly   875 ILLS-GLNRMLLDLNPRSRKPDHV-LNIIKYVTYNSWL--PRHAL---AAIKILASVTQL----- 927
            .:.. |:::.:|||....|....| :..|..:.:.:.|  .||..   :||:||:.:...
pombe   889 YIAELGISKYILDLTISRRAYKEVFMTRISSIVHLALLVGSRHKCFLRSAIEILSYLVDAEGFMN 953

  Fly   928 ---PNVSTQILSMYGQGSNEKLEIRQGFVECLEMEVCVGKHDDDLLDQLALNNHVPYLGFGDDLD 989
               |:.:..:.|:. :.:||...|..||:...|.:         .|..|:.|:
pombe   954 KRNPDENKLLCSII-RTANESKRIIFGFIRTFESQ---------FLTLLSTND------------ 996

  Fly   990 NEREMSGEREYSTIESQLELQAGDGALESKPASIELQLKEAIIKLFEMNLSQQ--LPNFVYFLLG 1052
                          ||.|                       |:||...||.|.  :.:....:||
pombe   997 --------------ESSL-----------------------ILKLLLNNLKQSGGVYSLALLILG 1024

  Fly  1053 VDVLREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSDKYCE---------HTARIVERIY 1108
            .|:      :....:.:..|...|.|.|.|:...:|       :.|         .|..|:.:..
pombe  1025 FDI------SSTNVITLRDQPGYVGSRVSLMNSLLD-------FIEGRTIVNGIWETPVIMVQAL 1076

  Fly  1109 HLFHGLCANRRTAETILRYFRLTCSDFLLRHLRSLPFRQHREDHVLHAMG--------------- 1158
            .:...||:...|:|..|...|.. ...|::.:...|....:   |:..:|
pombe  1077 EIVAFLCSCPLTSEVTLSVIRAR-PGLLVKMVDGEPILTQQ---VIQNLGGFSSEEVSMVSRCIR 1137

  Fly  1159 ---HLLNCVSIDVKLAAKHGQMTRFNQMCDILLIGNGMERSSHGLSMELGHSL-ISQPSSSFLA- 1218
               .::|.::.::..||..||....|:....|:..|           |..||. :||..|.|..
pombe  1138 SRTQIMNMLATEIHYAASVGQNKYLNEYVASLIRTN-----------EKTHSTELSQKESGFKIL 1191

  Fly  1219 --MDVLPAGGSISAVAHGAGSASLGAPNTGVKSLKPSLLQETSQGLHVTRLLDILVLEAGTLSQP 1281
              ||:|.....         |.:...||          :...:..:.:||
pombe  1192 EFMDILRIDPQ---------SITFELPN----------IPGFNLNMFITR--------------- 1222

  Fly  1282 QLEFFD-GHLITQLLRDCEASAEAGANSRANLINVRKLYYILTDELYMVQSIIASG--------- 1336
                || ||      .|.:...|          .|.|:|     .|:....:.:.|
pombe  1223 ----FDRGH------SDFQFDTE----------RVLKIY-----RLFFEAEMTSLGGSAEEKYSW 1262

  Fly  1337 --QRKAISTEIMLLLN----HAVNINRVRTQRCATLAFMAAWGQLVQVLFSNMPDAVLPATQRRQ 1395
              |:.:...|:...||    |.|.:..:  ..|.|     ||.:|..:|..:..:.:...
pombe  1263 LEQQNSKLKELAQRLNTFNAHVVLLQDI--HGCLT-----AWARLTGLLVDDCNEVISDV----- 1315

  Fly  1396 HIIDIVEKVLIKVQP--------IQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDLAAEDS 1452
            |..|.:.:||..|.|        .|..:.::..|.||:      |.:...:.....||:|.....
pombe  1316 HFDDFIWEVLRLVLPGVTVHNLGTQGTVSVTSSVIETI------LPHALRRIGALKPEELGKSTY 1374

  Fly  1453 LSNGNGNAIGNDSQVNALCLGQRAIGTGSDGGSGGGRDIGSGGNSSNLRFILKNLVQWIMISEVK 1517
            ...|                                           :..::..|::.|...: .
pombe  1375 FMEG-------------------------------------------IHDVIVGLLKGIQCQQ-S 1395

  Fly  1518 SQKLRINLYSSLLNCLRIAKRLRTDEHLEYQETLISRQESARTYNKEQRRDDRLRLKAMAAEVIG 1582
            .:.:|.|||.|||:.|                |:..:..||...:|             ...|..
pombe  1396 DESIRENLYGSLLSIL----------------TVFQKHTSANGGDK-------------VDPVFK 1431

  Fly  1583 TFGEKLI----------DTICHDAVTGHDVCRMLALACLDMISELQA-VST-LCDFVASRGYLKH 1635
            ...:|||          |.:..||:..:..|..|::..|:.:..:.. :|| |..:...|.::..
pombe  1432 DAFQKLITPNLLTSQFFDVLTKDALYTNGSCWELSVIILNFLHHVSPDISTHLYKYYLRRNFVSS 1496

  Fly  1636 ILESLDQSSTALCGILQPVPDHLRPLYVYESRMAFLTRMANSNVGARLLLTEQALGVLSNM 1696
            .   :|..|.|...:|....|.|..|...|:....|...|.:.:....:||...:.::..|
pombe  1497 F---IDAFSRAFSELLSSNKDVLEVLSGLEAGQCLLITFAQNKLTVHSVLTFDYIKLMVQM 1554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup205	NP_728308.1	Nup192	32..1796	CDD:314723	355/1944 (18%)
nup186	NP_588399.1	Nup192	4..1543	CDD:288726	352/1931 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1835
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004958
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103030
Panther	1	1.100	-	-	LDO	PTHR31344
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3859
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930