DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup205 and NUP205

DIOPT Version :10

Sequence 1:NP_728308.1 Gene:Nup205 / 33002 FlyBaseID:FBgn0031078 Length:2090 Species:Drosophila melanogaster
Sequence 2:NP_055950.2 Gene:NUP205 / 23165 HGNCID:18658 Length:2012 Species:Homo sapiens


Alignment Length:2170 Identity:626/2170 - (28%)
Similarity:1043/2170 - (48%) Gaps:273/2170 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ATHASTAVIEDMWTPYKHLYNTFQTAVSNRSGFTSD-LEQCLKKYKHNFSNLLRNPPRSEKSRNL 83
            ||..:......:|.|||.:::....|:..|...... |::.|||:|.:|.:|.:|||::.:....
Human     2 ATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKNVQQHEK 66

  Fly    84 LRNALNEGVPMQGHSRKTKMSQDLADEAVILSDMFDLDEGFAVELLCTAQRQQKHHPGLSRGLVA 148
            ::.|..|||.:||......:.:.|..||.||||:||:.|..|||||...:.||.|.|||:|||||
Human    67 VQKASTEGVAIQGQQGTRLLPEQLIKEAFILSDLFDIGELAAVELLLAGEHQQPHFPGLTRGLVA 131

  Fly   149 VLLYYDGRKAISCTLRDMFQVVSGVSWNTELPKEITGLVTNYAESLVDGSGILGRLLQLLEEMDV 213
            ||||:||::.|:.:|:.:.|...|.:|..||..|:..:.|.:.:.|:: .|:..::|.|:.::||
Human   132 VLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELME-QGLTYKVLTLVSQIDV 195

  Fly   214 DKECAMLTTNRAFGSKKHQNQVLGLYEDIQQALAMALFNWSAQRGLPRHIAIRLMHQLANRKNHD 278
            :.|...|...|..||:||:.:|..|.::.:|:||.:||.|:.|..|.:...:.|:..| .|...:
Human   196 NNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHL-ERVTVE 259

  Fly   279 AGGNMDDVTLIMLMALLYAYDTSML-LVTEEPNEHTTRLPIFSDREFAECFLEELYAQSSWQAPR 342
            |.|::|.|.|.:||||||.:|.|.: ..|||.::...:||:.:::::.......|.....|:.|.
Human   260 ANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIHQLPLLTEKQYIATIHSRLQDSQLWKLPG 324

  Fly   343 LNAIIAYSFGLTLASLRHAPLQLQATAIS-IINRDEMLIDEALGAQVFVFFHSLLLEKDLVYSTQ 406
            |.|.:..::.|.|..:...|   ..||:: ....||.:.:.|:...||:|....::..:..|..:
Human   325 LQATVRLAWALALRGISQLP---DVTALAEFTEADEAMAELAIADNVFLFLMESVVVSEYFYQEE 386

  Fly   407 FFYRRVHLLITDFIDFMNSKVSELRGRADESSHTIISFLNEGLEPPPNLDSNFELLMLCVAKMHG 471
            |:.||||.|||||:..|..||.:||.||||.:..|...:..|.|||.:|..:.|.|||.:.:::.
Human   387 FYIRRVHNLITDFLALMPMKVKQLRNRADEDARMIHMSMQMGNEPPISLRRDLEHLMLLIGELYK 451

  Fly   472 DPRVTIRLCNEYWGPGDP----------NGSTAFKNTSRSVSLFKFISLASDLLPQTLFKAYLKM 526
            .....:.|..|||.|.:|          .|....:...|.|.|.||:....||||.|::..||||
Human   452 KNPFHLELALEYWCPTEPLQTPTIMGSYLGVAHQRPPQRQVVLSKFVRQMGDLLPPTIYIPYLKM 516

  Fly   527 ISGLTRTDFSARCAFNMLR------VPQMATGGKYAVSWDHFFTTLGNYYTSMRNDFNTNIGMSG 585
            :.||......|...|::|:      |..:...|...|||:|||.:|..|:..:|.|.     .|.
Human   517 LQGLANGPQCAHYCFSLLKVNGSSHVENIQGAGGSPVSWEHFFHSLMLYHEHLRKDL-----PSA 576

  Fly   586 ETIYRTRSTPKAITQREAEHLVAVMGIIQAVAEHDEVSRIMICDHPNWQTPQVLLGLVACATPLF 650
            :::.......:.|||:|.:.|:|.:.:...:....|.:|:.:|:||.|....|:|||:.|:.|..
Human   577 DSVQYRHLPSRGITQKEQDGLIAFLQLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPV 641

  Fly   651 LKAEILHTLAALAKSKETARVIWFHLEASQIIPTVPVSRSYAQCSLLEEMEQIESRSEQYNLTRG 715
            ||||:|.||||..||.|.|..:|..||.:||:.||.:........:..|:.:||||.|:|.|||.
Human   642 LKAELLKTLAAFGKSPEIAASLWQSLEYTQILQTVRIPSQRQAIGIEVELNEIESRCEEYPLTRA 706

  Fly   716 ILQLLYTLMTTNLPKSLGAGQRTPAYEGYLKSMINSVLLKFYNRAYKVPSEKWQVGAQCLKLLYY 780
            ..||:.||:.::.|.:||||.|.|.::.||:.:.:||.|:|..|||:..:|||:|....|::.|.
Human   707 FCQLISTLVESSFPSNLGAGLRPPGFDPYLQFLRDSVFLRFRTRAYRRAAEKWEVAEVVLEVFYK 771

  Fly   781 LLATYRPSAMDFL---------ETVDEPPYPGFHVMMQLQLKSEMLQLLLCIVEEVRERLDNYNR 836
            ||..|.|...||:         |.:...| |||.:|..|..:|.||:|.|.::||..::||.|..
Human   772 LLRDYEPQLEDFVDQFVELQGEEIIAYKP-PGFSLMYHLLNESPMLELALSLLEEGVKQLDTYAP 835

  Fly   837 FQGKKLLEECSLYALLILEAALAKQNAFFEAHSAANCPILLSGLNRMLLDLNPRSRKPDHVLNII 901
            |.|||.||:...:.|.:|...|.|:|.|.:....:...:::..|.::|..:|||::|.|:|:||.
Human   836 FPGKKHLEKAVQHCLALLNLTLQKENLFMDLLRESQLALIVCPLEQLLQGINPRTKKADNVVNIA 900

  Fly   902 KYVTYNSWLPRHALAAIKILASVTQLPNVSTQILSMYGQGSNEKLEIRQGFVECLEMEVCVGKHD 966
            :|:.:.:..|..|..:.|||..::...|:..:::..:....:...::..||||||:.|       
Human   901 RYLYHGNTNPELAFESAKILCCISCNSNIQIKLVGDFTHDQSISQKLMAGFVECLDCE------- 958

  Fly   967 DDLLDQLALNNHVPYLGFGDDLDNEREMSGEREYSTIESQLELQAGDGALESKPASIELQLKEAI 1031
                                  |.|       |:..:|...|       ||.|..:|..:.:..|
Human   959 ----------------------DAE-------EFVRLEEGSE-------LEKKLVAIRHETRIHI 987

  Fly  1032 IKLFEMNLSQQLPNFVYFLLGVDVLREFMANGRQHLAI-EMQSSCVNSVVLLLEKYMDKQRHSDK 1095
            :.|...:|....||...:|||.::.:.......|...: ....:|:::::.:|||..: .|....
Human   988 LNLLITSLECNPPNLALYLLGFELKKPVSTTNLQDPGVLGCPRTCLHAILNILEKGTE-GRTGPV 1051

  Fly  1096 YCEHTARIVERIYHLFHGLCANRRTAETILRYFRLTCSDFLLRHLRSLPF-RQHREDHVLHAMGH 1159
            ....:.::.|..|.:.:.|||...|:...:||.| |..|||...|:.||| .:..|..:|:.|..
Human  1052 AVRESPQLAELCYQVIYQLCACSDTSGPTMRYLR-TSQDFLFSQLQYLPFSNKEYEISMLNQMSW 1115

  Fly  1160 LLNCVSIDVKLAAKHGQMTRFNQMCDILLIGNGMERSSHGLSMELGHSLISQPSSSFLAMDVLPA 1224
            |:...||::::.:.:.|.:...::..:||....::..|.|   |.|....::..|.||..|    
Human  1116 LMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKPYSDG---EGGIEDENRSVSGFLHFD---- 1173

  Fly  1225 GGSISAVAHGAGSASLGAPNTGVKSLKPSLLQETSQGLHVTRLLDILVLEAGTLSQPQLEFFDGH 1289
                                |..|..:           .:..:||.:..........||:|||..
Human  1174 --------------------TATKVRR-----------KILNILDSIDFSQEIPEPLQLDFFDRA 1207

  Fly  1290 LITQLLRDCEASAEAGANSRANLI-NVRKLYYILTDELYMVQSIIASGQRKAISTEIMLLLNHAV 1353
            .|.|::.:||..     |.|...: ||:.|:.:|..|:..:|.:.|.|||..:..||..:|.:.|
Human  1208 QIEQVIANCEHK-----NLRGQTVCNVKLLHRVLVAEVNALQGMAAIGQRPLLMEEISTVLQYVV 1267

  Fly  1354 NINRVRTQRCATLAFMAAWGQLVQVLFSNMPDAVLPATQRRQHIIDIVEKVLIKV------QPIQ 1412
            ..|::.....|....:.:|.|||:::.:..|..::.|..|:..|.||::.|..|:      |.:.
Human  1268 GRNKLLQCLHAKRHALESWRQLVEIILTACPQDLIQAEDRQLIIRDILQDVHDKILDDEAAQELM 1332

  Fly  1413 PII-------------EISVQVSETVLLLLANLRYC-----CYQAEDQSPEDLAAEDSLSNGNGN 1459
            |::             .:..:..||.:|..|...|.     |:.:  ..||:             
Human  1333 PVVAGAVFTLTAHLSQAVLTEQKETSVLGPAEAHYAFMLDSCFTS--PPPEE------------- 1382

  Fly  1460 AIGNDSQVNALCLGQRAIGTGSDGGSGGGRDIGSGGNSSNLRFILKNLVQWIMISEVKSQKLRIN 1524
                    |.|      :|..|.|             .|:|..|||.|:.:|:.:....|::|.:
Human  1383 --------NPL------VGFASIG-------------DSSLYIILKKLLDFILKTGGGFQRVRTH 1420

  Fly  1525 LYSSLLNCLRIAKRLRTDEHLE-YQETLISRQESAR-TYNKEQRRDDRLRLKAMAAEVIGTFGEK 1587
            ||.|||..|:||:|....:.|| .::|:..|..:.. .::|.||.:         ..:|.::|..
Human  1421 LYGSLLYYLQIAQRPDEPDTLEAAKKTMWERLTAPEDVFSKLQREN---------IAIIESYGAA 1476

  Fly  1588 LIDTICHDAVTGHDVCRMLALACLDMISELQAVSTLCDFVASRGYLKHILESLDQSSTALCGILQ 1652
            |::.:|.||..||::.||||||.||.|..:........::::.||||.:::||.:....|..:|.
Human  1477 LMEVVCRDACDGHEIGRMLALALLDRIVSVDKQQQWLLYLSNSGYLKVLVDSLVEDDRTLQSLLT 1541

  Fly  1653 PVPDHLRPLYVYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQPDL-KSSELNRNEPQ 1716
            |.|..|:.||.|||:||||||:|....||..||....:..|:..:|||.:|:. ..|.....:|.
Human  1542 PQPPLLKALYTYESKMAFLTRVAKIQQGALELLRSGVIVRLAQCQVYDMRPETDPQSMFGMRDPP 1606

  Fly  1717 TFLPSIDDRFRSILLPALSLCDAIVNSLGPRNNSAAVQVLNFLFAHIDMVEAMLRSATPYMDLGH 1781
            .|:|:..||:|.||||||.||..|:.|...::..||.|||.||.:|.|.::|:||...  :..|.
Human  1607 MFIPTPVDRYRQILLPALQLCQVILTSSMAQHLQAAGQVLQFLISHSDTIQAILRCQD--VSAGS 1669

  Fly  1782 LQQVAVISNLFARASTHE-LTALEDSVQ----LDLRNRLGRVQQLMIVVFGRFCVSEPTIRRMLQ 1841
            ||::|:::.:.::|:... |:.|:..|.    ::|:..:||.|:..:.:..||..|:     .|:
Human  1670 LQELALLTGIISKAALPGILSELDVDVNEGSLMELQGHIGRFQRQCLGLLSRFGGSD-----RLR 1729

  Fly  1842 QDEEQQTNPTDD--SKRLRVKYFL-DIAANVSLYCRNVVTSHSKDSMTSKYLLTTVINDVTLLTG 1903
            |.:.|..|...|  ||:..::..: .|.|||..||::::...|.....:..|.|..:::.....|
Human  1730 QFKFQDDNVEGDKVSKKDEIELAMQQICANVMEYCQSLMLQSSPTFQHAVCLFTPSLSETVNRDG 1794

  Fly  1904 KMSSKKLTTIMHTILNQLKGSIGYYLSQK-----SIADNLLQQRASLPNI-------------SF 1950
            .....:...:.:..|..| |.|.|.|.|.     |..|:..|..:.|.|:             |.
Human  1795 PRQDTQAPVVPYWRLPGL-GIIIYLLKQSANDFFSYYDSHRQSVSKLQNVEQLPPDEIKELCQSV 1858

  Fly  1951 GPNGKQSYIELSQRY-----------NEKRSELRQAVFIAEQNLYLLWIHLDFYLRNTIDYANEN 2004
            .|.|... |..:|:|           |.:...|....||.|..|::||.||::||.:.:...:::
Human  1859 MPAGVDK-ISTAQKYVLARRRLVKVINNRAKLLSLCSFIIETCLFILWRHLEYYLLHCMPTDSQD 1922

  Fly  2005 R---------------NAINESNMDDDNDMSVLNASQEEIVQLKQLLISTFNETFCTQLINASED 2054
            .               :..:|:|:|..:.::::  ||.::.||:...|:.|.|:...:|::....
Human  1923 SLFASRTLFKSRRLQDSFASETNLDFRSGLAIV--SQHDLDQLQADAINAFGESLQKKLLDIEGL 1985

  Fly  2055 YS-IKCK-GFNGSLLRRIKALVQFA 2077
            || ::.: .|..:|:|||:.|::.:
Human  1986 YSKVRSRYSFIQALVRRIRGLLRIS 2010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup205NP_728308.1 Nup192 182..1795 CDD:463387 486/1669 (29%)
NUP205NP_055950.2 Nup192 168..1684 CDD:463387 485/1667 (29%)

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