Protein Alignment Nup205 and npp-3

DIOPT Version :9

• Sequence 1: NP_728308.1
• Gene: Nup205 / 33002
• FlyBaseID: FBgn0031078
• Length: 2090
• Species: Drosophila melanogaster
• Sequence 2: NP_496534.1
• Gene: npp-3 / 174823
• WormBaseID: WBGene00003789
• Length: 1696
• Species: Caenorhabditis elegans
• Alignment Length: 1839
• Identity: 348/1839 - (18%)
• Similarity: 664/1839 - (36%)
• Gaps: 447/1839 - (24%)

  Fly    31 MWTPYKHLYN---TFQTAVSNRSGFTSDLEQCLKKYKHNFSNLLRNPPRSEKSRNLLRNALNEGV 92
            ||...:..|.   :|.....:|.  .::|...::||:...||:|.||.|:.|.|..|:..   .|
 Worm     1 MWIEIRKFYELIVSFTAFDDDRK--INELFNEIEKYRWRLSNILLNPRRTGKDREKLKPG---NV 60

  Fly    93 PMQGHSRKTKMSQDLADEAVILSDMFDLDEGFAVELLCTAQRQQKHHPGLSRGLVAVLLYYDGRK 157
            .|.|  .:..:.:::..||:||||:|.|:|..||:|:...:.|:.|..||:|||:||:.|||..:
 Worm    61 EMAG--VEVALDEEICSEALILSDIFQLNELEAVDLILAGEAQKIHFEGLNRGLIAVVCYYDAHR 123

  Fly   158 AISCTLRDMFQVVSGVSWNTELPKEITGLVTNYAESLVDGSGILGRLLQLLEEMDVDKECAMLTT 222
            .:..|:|.|      :.|:.|   :|...::.:..|......::..|.|.|....|..|.|.|.:
 Worm   124 LLIATMRQM------LKWDRE---DIPQRISKFLNSTFINEDVIKNLFQQLINFTVQSEFARLQS 179

  Fly   223 N--RAFGSKKHQNQVLGLYEDIQQALAMALFNWSAQRGLPRHIAIRLMHQLANRKNHDAGGNMDD 285
            .  ...|..|||..|....|:|:..:...:   |....:|...|:.:.:.|...........:..
 Worm   180 PDVNGLGGSKHQKLVRNAIEEIRSEVIGCI---SMICEIPGGNAVSISNHLFQIVKAVPPEKLSC 241

  Fly   286 VTLIMLMALLYAYDTSMLLVTEEPNEHTTRLPIFSDREFAECFLEELYAQSSWQAPRLNAIIAYS 350
            .:|...::|:....:.:|....:..:..|.:            :..:..::.|....:...:..:
 Worm   242 SSLTAWISLVKITSSEVLSQVHDAQQVLTNM------------IAHIRNETDWSDQAMCGTLQLA 294

  Fly   351 FGLTLASLRHAP---LQLQATAISIINRDEMLIDEALGAQVFVFFHSLLLEKDLVYSTQFFYRRV 412
            ..:.|.|:..:|   |.::...:.:    |.:||.::....|.:     |.:.::.|..|.|...
 Worm   295 CAVALKSIASSPSDHLGIENIKVDV----ERVIDRSIRNMAFHY-----LRQAIIKSEHFRYAHQ 350

  Fly   413 HLLI----------------------TDFIDFMNSKVSE--LRGRADESSHTI-----ISFLNEG 448
            .::|                      ||.::|::.:..|  ...:.|..|.|:     ::.....
 Worm   351 FMIIDELLKQLISYFPAKLMETERNSTDELNFLDDQKKEQSTTQKPDPKSQTVHITDKVTAQLSS 415

  Fly   449 LEPPPNLD---SNFELLMLCVAKMHGDPRVTIRLCNEYWGPGDPNGSTAFK-------------- 496
            .:|..|.|   |.:|..:.|...:: :.:||     :|  ....|..||.:
 Worm   416 TDPSNNYDSALSQYENFLRCFVDLY-EMQVT-----DY--AHQKNARTARERELQEQIEENSMAF 472

  Fly   497 NTSRSVSLFKFISLASDLLPQ---TLFKAYLKMISGLTRTDFSARCAFNMLRVPQMATGGKYAVS 558
            :|.||:.|.:.:..|.  ||.   ....|||:|.:.:.:.:.:|...:::......   |..:..
 Worm   473 STERSIELCRLLERAR--LPNHHVVHSVAYLEMCAAVCKNENTAALLYDIFSKEHC---GPDSYG 532

  Fly   559 WDHFFTTLGNY--------YTSMRNDFNTNIGMSGETIYRTRSTPK---------AITQREAEHL 606
            |:...:.|..|        |.| .:..|.:..||..|.:..:.:..         .|..:|...|
 Worm   533 WESLASALKGYDRLYREQKYAS-NSRHNQSQTMSMSTSFHQQQSLNLTLRPGDKITIPAQELSGL 596

  Fly   607 VAVMGIIQAVAEHDEVSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHTLAALAKSKETARV 671
            ||.:.:...||:.:|.:.:...|.|:|....|:..|.....||.:||.:|..|.|:|:.|.:|..
 Worm   597 VAWIHMATKVAQLNERAAMRFSDDPSWTLCSVVASLSTSPVPLSMKASMLDLLTAVARLKGSAPR 661

  Fly   672 IWFHLEASQIIPTVPVSRSYAQCSLLEEMEQIESRSEQYNLTRGILQLLYT-LMTTNLPKSLGAG 735
            ||..:..:|:..:   |.......:.:|:|:.|..::||:::...::|:.| ||..:||:
 Worm   662 IWQAIHLNQLCYS---SDGGTLMGIQQELEERECVAKQYDVSLAFVKLMTTLLMHRSLPE----- 718

  Fly   736 QRTPAYEGYLKSMINSVLLKFYNRAYKVPSEKWQVGAQCLKLLYYLL--ATYRPSAMDFLETVDE 798
            ..||    :::.:..|:|..|..|:|....:.|::....|:....||  ....|.|:...|.
 Worm   719 YATP----FIQFVTRSILAHFSTRSYNSVVQMWELAEWSLRATNALLEHGIVEPRAVASNEV--- 776

  Fly   799 PPYPGFHVMMQLQLKSE--MLQLLL-CIVEEVRERLDNYNRFQGKKLLEECSLYALLILEAALAK 860
                  |:.:..|..::  |.:.:. .|:|:.:...|.|...|...  .:.:|.||.||..|:..
 Worm   777 ------HIAILTQCLNDTPMYRAITRVIMEDCQAHNDPYVTRQSPS--SDAALIALRILSRAIIL 833

  Fly   861 QNAFFEAHSAANCPILLSGLNRML------------LDLNPRSRKPDHVLNIIKYVTYNSWLPRH 913
            ..|.......::..|:::.:..::            |||            :..|:......|.|
 Worm   834 HPALRACARVSSSDIMIASIPSLVFSPIISASACTPLDL------------VFHYLHMTDDYPVH 886

  Fly   914 ALAAIKILASVTQLPNVSTQILSMYGQGSNEKLEIRQ------GFVECLEMEVCVGKHDDDLLDQ 972
            :|.|.:||..|          ::..|....:.||:.:      ..|..:...:|.......:.|.
 Worm   887 SLYAARILRDV----------MATRGAAEVKMLELLRSRNSAASHVRAVRAAICATSIQYTIDDS 941

  Fly   973 LALNNHVPYLGFGDDLDNEREMSGEREYSTIESQLELQAGDGALESKPASIELQLKEAIIKLFEM 1037
            ||..         :|.||.....||.....||:..:             :|:.|:.....:|.:.
 Worm   942 LAKE---------EDTDNPHFARGETARILIETLSD-------------AIDCQVTRTGNRLTDT 984

  Fly  1038 NLSQQLPNFVYFLLGVDVLREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSD----KYCE 1098
            |      |..|:||   ..|...|:.::....:...:.::.|:.::|:::..::..|    ...|
 Worm   985 N------NICYYLL---AFRPSKAHTKELYQADDVLTGLHYVLYIIEQFVMSKKPFDLPFSALLE 1040

  Fly  1099 HTARIVERIYHL---FHG--LCANRRTAETILRYFRLTCSDFLLRHLRSLPFRQHREDHVLHA-- 1156
            ...|:::|:..:   |..  ||..|  :..|:.  :||.|.|:...|.....|.:.....:.|
 Worm  1041 PAFRLMQRLVSITCPFSKPVLCFMR--SSNIIE--KLTTSPFICSALTLESARDNTYAQGVFAVR 1101

  Fly  1157 ---MGHLLNCVSIDVKLAAKHGQMTRFNQMCDILLIGNGMERSSHGLSMELGHSLISQPSSSFLA 1218
               :|::|:..::::......|..:|..::...||      .||         ||:::    :..
 Worm  1102 RMIVGYILHFAAVEISAMLTTGHFSRPEKLYRALL------ESS---------SLVAE----YTQ 1147

  Fly  1219 MDVLPAGGSISAVAHGAGSASLGAPNTGVKSLKPSLLQETSQGLHVTRLLDILVLEAGTLSQPQL 1283
            |:.......::.||.|:..             |.:||....:...|.|..::|        .|.|
 Worm  1148 MEEDDDDEDMAPVASGSND-------------KANLLFSLIRRATVPRKNELL--------YPNL 1191

  Fly  1284 EFFDGHLITQLLRDCEASAEAGANSRANLINVRKLYYILTDELYM-------VQSIIA-SGQRKA 1340
            ..||...:.:|...|         ...|:..|.:.     |.||:       ::::.. ||:.|.
 Worm  1192 VHFDVAKLHELFDAC---------LTVNIYGVAQY-----DVLYLNRLLRREIETVYTESGEMKY 1242

  Fly  1341 ISTEIMLLLNHAVNINRVRTQRCATLAFMAAWGQLVQV--------LFSNMPDAVLPATQRRQHI 1397
            :..|:..:|.:...||.......|:...::....|:.|        .|||....|:
 Worm  1243 VQKEMEGVLEYCAEINASLLSESASERIVSGCTALLNVFSVFAPVNFFSNKMQIVI--------- 1298

  Fly  1398 IDIVEKVLIKVQPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDLAAEDSLSNGNGNAIG 1462
                                              .|..||...:.:               :.:|
 Worm  1299 ----------------------------------FRDACYVLIEMA---------------SGVG 1314

  Fly  1463 NDSQVNALCLGQRAIGTGSDGGSGGGRDIGSGGNSSNLRF------------ILKNLVQWIMISE 1515
            ..|.|.|.....|.:.|.:              ..:.:.:            :.|:::...:...
 Worm  1315 GSSLVTACQTFHRLVLTLT--------------KLAQVEYPRLLDLREFFAPLFKSMIDLFLQPG 1365

  Fly  1516 VKSQKLRINLYSSLLNCLR-IAKRLRTDEHLEYQETLI----------SRQESARTYNKEQRRDD 1569
            .|....::.||.::...|| :.::...|...|.:|.|:          |..|.....:|
 Worm  1366 EKCVDAKVQLYKTMRFILRTLFEKNSIDTVNEAEEWLLDGLIAPLETPSSDEIVNIVDK------ 1424

  Fly  1570 RLRLKAMAAEVIGTFGEKLIDTICHDAVTGHDVCRMLALACLDMISE-LQAVSTLCDFVASRGYL 1633
                  ||.|:.......:.|...|....|    .|||   .|:|.| |:....:|:..:..|..
 Worm  1425 ------MADEIARHLEGSIADLPKHRKAAG----IMLA---NDLIHEDLKGNKKICNHFSKSGVP 1476

  Fly  1634 KHILESL--------------DQSSTALCGILQPVPDHLRPLYVYESRMAFLTRMANSNVGARLL 1684
            :.:.|.|              .:....:.|:.|  .:|:....::.|.:.||||...|..|..:|
 Worm  1477 RILCEELLHIDFDWNIVTAARKEGGGGVAGVNQ--AEHISNYNLFISILTFLTRYGTSESGWHVL 1539

  Fly  1685 LTEQALGVLSNMKVYDQQP 1703
            .......:|:.|..:.:.|
 Worm  1540 AELAVSEILAEMPPFIEPP 1558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup205	NP_728308.1	Nup192	32..1796	CDD:314723	347/1838 (19%)
npp-3	NP_496534.1	Nup192	24..>1260	CDD:288726	283/1421 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1835
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53054
OrthoDB	1	1.010	-	-		D106148at33208
OrthoFinder	1	1.000	-	-		FOG0004958
OrthoInspector	1	1.000	-	-		oto17178
orthoMCL	1	0.900	-	-		OOG6_103030
Panther	1	1.100	-	-	LDO	PTHR31344
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3859
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880