Protein Alignment Nup205 and nup205

DIOPT Version :9

• Sequence 1: NP_728308.1
• Gene: Nup205 / 33002
• FlyBaseID: FBgn0031078
• Length: 2090
• Species: Drosophila melanogaster
• Sequence 2: NP_001135596.1
• Gene: nup205 / 100216151
• XenbaseID: XB-GENE-1009711
• Length: 2011
• Species: Xenopus tropicalis
• Alignment Length: 2159
• Identity: 635/2159 - (29%)
• Similarity: 1033/2159 - (47%)
• Gaps: 278/2159 - (12%)

  Fly    31 MWTPYKHLYNTFQTA-VSNRSGFTSDLEQCLKKYKHNFSNLLRNPPRSEKSRNLLRNALNEGVPM 94
            :|.||:.::.|...| |..:......|:..|||||.:|.:|.:|||:|.:....::.|.:||:|:
 Frog    13 LWGPYREIWQTVVGALVKRQPEAIHSLDIVLKKYKPDFISLFKNPPKSAQQHERVQKASSEGIPI 77

  Fly    95 QGHSRKTKMSQDLADEAVILSDMFDLDEGFAVELLCTAQRQQKHHPGLSRGLVAVLLYYDGRKAI 159
            :|..|...:...|..||.||||::::.|..|||||...::||....||:|||||:|||:||:..:
 Frog    78 KGTQRTRILEGQLIKEAFILSDLYNIGEVAAVELLLLGEQQQPTFHGLTRGLVAILLYWDGKSCM 142

  Fly   160 SCTLRDMFQVVSGVSWNTELPKEITGLVTNYAESLVDGSGILGRLLQLLEEMDVDKECAMLTTNR 224
            :.:|..:.|...|.::......|:..:||.:.:.|:: .|:..::|.|:.::||:.|...|..:|
 Frog   143 ADSLLHLIQARKGRTFTLNHSPELVSMVTRFTDDLME-QGLTNKILTLISQIDVNNEFDKLLKDR 206

  Fly   225 AFGSKKHQNQVLGLYEDIQQALAMALFNWSAQRGLPRHIAIRLMHQLANRKNHDAGGNMDDVTLI 289
            ..|::||:.:|..|.::.:|:||.:|::||.|..|.:...:.|:..| .:...:..|::|.|.|.
 Frog   207 GLGNEKHRKEVSDLIKECRQSLAHSLYSWSCQTPLNKEDTLLLIGYL-EKVTVEGDGSLDKVNLT 270

  Fly   290 MLMALLYAYDTSML-LVTEEPNEHTTRLPIFSDREFAECFLEELYAQSSWQAPRLNAIIAYSFGL 353
            :||:|||..|...| ..|::..|...:..:|.||::.......|:....|:.|.:.|.:..::.|
 Frog   271 LLMSLLYCLDVGFLEQATDDREELIKQTSMFMDRQYIAAIHNRLHDTQPWKLPGMQATVRLAWAL 335

  Fly   354 TLASLRHAPLQLQATAISIINRDEMLIDEALGAQVFVFFHSLLLEKDLVYSTQFFYRRVHLLITD 418
            .|..:...     :..:.....||.:.:.|:...||:|....::..:...:.:||.||:|.|:||
 Frog   336 ALRGISQF-----SEVLEFSEADEPMAELAISGNVFLFLTEAVVGSESFCADEFFIRRIHKLVTD 395

  Fly   419 FIDFMNSKVSELRGRADESSHTIISFLNEGLEPPPNLDSNFELLMLCVAKMHGDPRVTIRLCNEY 483
            |:..|..||.:||.||:|.:..|...:..|.|||.:|..:.|.|:|.:.:::......:.|..||
 Frog   396 FLTLMPMKVKQLRNRAEEDARLIHMSMQMGNEPPASLRRDLEHLLLLIGELYRIDPFHLELALEY 460

  Fly   484 WGPGDPNGSTAFKNT----------SRSVSLFKFISLASDLLPQTLFKAYLKMISGLTRTDFSAR 538
            |.|.:|..||:...:          .|.|.|.||:...|||||.||:..||||:.||......|.
 Frog   461 WCPAEPLQSTSLMGSFLGVAHQRPPQRQVVLSKFVRQMSDLLPATLYIPYLKMLRGLASGPQCAH 525

  Fly   539 CAFNMLRVPQMATGGKYA----------VSWDHFFTTLGNYYTSMRNDFNTNIGMSGETIYRTRS 593
            ..|::|:    |.||..|          |||||||.:|..|:..:|.|.     .|.::|:....
 Frog   526 YCFSLLK----ANGGSSAESLQAAGGSPVSWDHFFHSLMLYHEHLRRDL-----PSTDSIHLRHP 581

  Fly   594 TPKAITQREAEHLVAVMGIIQAVAEHDEVSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHT 658
            ..:.|||||.:.|:|.:.:...:.:..|.:|:.:|:|..|....|:|||:.|:.|..||||:|.|
 Frog   582 PLRGITQRELDGLIACLQLTLTIVDWSESARLALCEHAQWMPVVVILGLLQCSIPPLLKAELLKT 646

  Fly   659 LAALAKSKETARVIWFHLEASQIIPTVPVSRSYAQCSLLEEMEQIESRSEQYNLTRGILQLLYTL 723
            |||..||.|.|..:|..||.:||:.||..........:..|:.:||||.|:|.|||...||:.||
 Frog   647 LAAFGKSPEIAASLWQSLEYTQILQTVRTPGLRQGVGIEVELNEIESRCEEYPLTRAFCQLISTL 711

  Fly   724 MTTNLPKSLGAGQRTPAYEGYLKSMINSVLLKFYNRAYKVPSEKWQVGAQCLKLLYYLLATYRPS 788
            :.::.|.:||||.|.|.:|.||:.:.::|.|:|..|||:..:|||:|....|.:.|.||..|.|.
 Frog   712 VESSFPTNLGAGLRAPGFEPYLQFLRDTVFLRFRTRAYRRGAEKWEVAEAVLDVFYKLLKDYEPQ 776

  Fly   789 AMDFL---------ETVDEPPYPGFHVMMQLQLKSEMLQLLLCIVEEVRERLDNYNRFQGKKLLE 844
            ..||:         |.|...| |||.:|..|...|.||:|.|.::||...:||.|..|.|||.||
 Frog   777 PEDFVDQYVELQGEERVAFKP-PGFSLMHHLLNDSPMLELCLSLMEEGVTQLDTYAPFPGKKHLE 840

  Fly   845 ECSLYALLILEAALAKQNAFFEAHSAANCPILLSGLNRMLLDLNPRSRKPDHVLNIIKYVTYNSW 909
            :...|..::|...|.|:|.|.:....::..::::.|.::|..:||||:|.|:|:||.:|:.:.:.
 Frog   841 KAVAYCFMLLNQTLQKENRFMDLLRESHLSLIVTPLEQLLQGINPRSKKADNVINIARYLYHGNS 905

  Fly   910 LPRHALAAIKILASVTQLPNVSTQILSMYGQGSNEKLEIRQGFVECLEMEVCVGKHDDDLLDQLA 974
            .|..|..:.|||.|:.....:..:|:..:.|..|...::..|||.||:.|     ..::|||.
 Frog   906 NPELAFESAKILCSIACNSKIQEKIVGDFTQDQNVTQKLMVGFVSCLDSE-----EAEELLDS-- 963

  Fly   975 LNNHVPYLGFGDDLDNEREMSGEREYSTIESQLELQAGDGALESKPASIELQLKEAIIKLFEMNL 1039
                                         |.::|.||       |..:|....|..|:.|...:|
 Frog   964 -----------------------------EKEVEDQA-------KQTNIRYMTKIHILNLLITSL 992

  Fly  1040 SQQLPNFVYFLLGVDVLREFMANGRQHLAI-EMQSSCVNSVVLLLEKYMDKQRHSDKYCEHTARI 1103
            ..:.||...||||.::.:.......|...: ....:|::|::.:|.|..| .|........|..:
 Frog   993 EMKAPNLAMFLLGYELKKPVSTTNLQDSGVLGCPRTCLHSILDILRKGTD-GRAGPIAIWDTPHL 1056

  Fly  1104 VERIYHLFHGLCANRRTAETILRYFRLTCSDFLLRHLRSLPFR-QHREDHVLHAMGHLLNCVSID 1167
            .|..|.:.:.|||...|:...:||.| |..|||...|:.|||. :..|...::.|..|:...||:
 Frog  1057 AELCYQVIYQLCACSDTSGPTMRYLR-TSQDFLFTQLQHLPFSVEEYEISAMNQMSWLMKTASIE 1120

  Fly  1168 VKLAAKHGQMTRFNQMCDILLIG------------NGMERSSHGLSMELGHSLISQPSSSFLAMD 1220
            :::.:.:.|.:...::..:||..            .|||..|..|             |.||..|
 Frog  1121 LRITSLNRQRSHTQRLLHLLLDDMPTKPYSAADGEGGMEDESRSL-------------SGFLHFD 1172

  Fly  1221 VLPAGGSISAVAHGAGSASLGAPNTGVKSLKPSLLQETSQGLHVTRLLDILVLEAGTLSQPQLEF 1285
                  :.|.|..                             .:.|:||.:..........||:|
 Frog  1173 ------TTSKVRR-----------------------------KILRILDSIHFSNEIPDPLQLDF 1202

  Fly  1286 FDGHLITQLLRDCEASAEAGANSRANLINVRKLYYILTDELYMVQSIIASGQRKAISTEIMLLLN 1350
            ||...|.|::.:||.....|    ..:.||:.|:.:|..|:..:|.:.|.|||..:..||..:|.
 Frog  1203 FDRSQIEQVIANCEHKNRRG----QTVCNVKLLHRVLVAEVNALQGMAAIGQRPLLMEEINTILQ 1263

  Fly  1351 HAVNINRVRTQRCATLAFMAAWGQLVQVLFSNMPDAVLPATQRRQHII-----DIVEKVL--IKV 1408
            :.|..|::.....|....:.:|.|||:::.:..|..::| |:.||.||     |:.:|:|  ...
 Frog  1264 YVVERNKLLQCLHAKRHALESWRQLVEIILTACPQDLIP-TEHRQLIIRDLLQDLHDKILDDDAA 1327

  Fly  1409 QPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDLAAEDSLSNGNGNAIGNDSQVNALCLG 1473
            |.:.||      |:..|..|..:|        .||......:...:.|.|     .||...:..|
 Frog  1328 QELMPI------VAGAVFTLTTHL--------SQSVRTELKQPMAAAGLG-----QSQYVQMLDG 1373

  Fly  1474 QRAIGTGSDGGSGGGRDIGSGGNSSNLRFILKNLVQWIMISEVKSQKLRINLYSSLLNCLRIAKR 1538
            ..|...|::..|.|...||    .|:|..||:||:::|:.:....|::|.:||.|||..|:||:
 Frog  1374 SFAAPPGTENLSAGFASIG----DSSLHMILRNLLEFILKTGGGFQRVRAHLYGSLLYYLQIAQ- 1433

  Fly  1539 LRTDE-------HLEYQETLISRQESARTYNKEQRRDDRLRLKAMAAEVIGTFGEKLIDTICHDA 1596
             |.||       |....|.|.:.::   .::|.||  |.|       .:..::|..|::.:|.||
 Frog  1434 -RPDEPDTLESAHKTMWERLTAPED---VFSKLQR--DNL-------SIFESYGTALMEVVCRDA 1485

  Fly  1597 VTGHDVCRMLALACLDMISELQAVSTLCDFVASRGYLKHILESLDQSSTALCGILQPVPDHLRPL 1661
            ..|||:.||||||.||.|..:.....|. ::::.||||.:::||.:....|..:|.|....|:.|
 Frog  1486 CDGHDIGRMLALALLDRIVSVDRQQWLL-YLSNSGYLKVLVDSLAEDDMVLRNLLTPQAPLLKAL 1549

  Fly  1662 YVYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQPDL-KSSELNRNEPQTFLPSIDDR 1725
            |:|||:||||||:|.|..||..||....:..|:..:|||.:|:. ........|...|:|:..:|
 Frog  1550 YIYESKMAFLTRVAKSQQGALELLRSGVIVRLAQCQVYDMRPETDPHGVFGMRETPVFIPAPVER 1614

  Fly  1726 FRSILLPALSLCDAIVNSLGPRNNSAAVQVLNFLFAHIDMVEAMLRSATPYMDLGHLQQVAVISN 1790
            :|.||||||.:|..|:.|...::..||.|||.||.||.|.::|:|||...  .||.||::|:::.
 Frog  1615 YRQILLPALQICQLILTSSTAQHLQAAGQVLQFLIAHSDTIQAILRSQEG--SLGSLQELALLTG 1677

  Fly  1791 LFARAS----THEL-TALEDSVQLDLRNRLGRVQQLMIVVFGRFCVSEPTIRRMLQQDEEQQTNP 1850
            :.::|:    .:|| ..|.:...::|:..:||.|:..:.:..||..|: .:|::..||:..|  |
 Frog  1678 IISKAALPGVLNELDIGLNEGSMMELQGHIGRFQRQCLALLNRFGGSD-RLRQLSLQDDSSQ--P 1739

  Fly  1851 TDDSKRLRVKYFL-DIAANVSLYCRNVVTSHSKDSMTSKYLLTTVINDVTLLTGKMSSKK----- 1909
            ...|||..::..: .|.:||..||:.::..:|.....:..|.|..:.:.:...|.....:
 Frog  1740 DGVSKRDDMELAMQQICSNVMEYCQTLMIQNSPSFQQTVCLFTPNLTESSSRDGTRQDSQVSILP 1804

  Fly  1910 ------LTTIMHTILNQLKGSIGYY-LSQKSIADNLLQQRASLPN-------ISFGPNGKQSYIE 1960
                  |..::|.:.........|| :.::|::.  ||....||.       .|..|.|... |.
 Frog  1805 SWRLPGLGIVIHLLKQSANNFFTYYDIHRQSVSK--LQNVEQLPPDEIKELCQSEMPVGVDK-IS 1866

  Fly  1961 LSQRY-----------NEKRSELRQAVFIAEQNLYLLWIHLDFYLRN--TID-----YANE---N 2004
            .:|:|           |.:...|....:|.|..|::||.||:.||.:  |.|     ::|.   |
 Frog  1867 TTQKYALARRRLVKLINSRAKLLSLCSYIIETCLFILWRHLEHYLLHCTTSDSQDPVFSNTTFGN 1931

  Fly  2005 RNAINESNMDDDNDMSVL---NASQEEIVQLKQLLISTFNETFCTQLINASEDYSIKCK-----G 2061
            |...:..|.|.:.|:..|   ..||:||..|.:...::|.|:...:|::..   |:.||     .
 Frog  1932 RRFQDTINTDPNMDLRNLRQNKVSQQEIDMLLREGANSFGESLQKRLLDIE---SLYCKVRSRHS 1993

  Fly  2062 FNGSLLRRIKALVQ 2075
            |..:|:|||:.|::
 Frog  1994 FIQALVRRIRGLLR 2007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup205	NP_728308.1	Nup192	32..1796	CDD:314723	555/1823 (30%)
nup205	NP_001135596.1	Nup192	14..1683	CDD:371785	555/1823 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	770	1.000	Domainoid score	I85
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H45971
Inparanoid	1	1.050	807	1.000	Inparanoid score	I479
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106148at33208
OrthoFinder	1	1.000	-	-		FOG0004958
OrthoInspector	1	1.000	-	-		oto102801
Panther	1	1.100	-	-	LDO	PTHR31344
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3859
SonicParanoid	1	1.000	-	-		X6064
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190