DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THADA and TRM732

DIOPT Version :9

Sequence 1:	NP_608361.3	Gene:	THADA / 33001	FlyBaseID:	FBgn0031077	Length:	1746	Species:	Drosophila melanogaster
Sequence 2:	NP_013986.1	Gene:	TRM732 / 855301	SGDID:	S000004872	Length:	1420	Species:	Saccharomyces cerevisiae

Alignment Length:	1072	Identity:	212/1072 - (19%)
Similarity:	376/1072 - (35%)	Gaps:	308/1072 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 AVSELKSTVTNLLVF------LSKHLFIYSKSLGEMHAHLPDDQKLLYQRILAQLQVFALQNISS 378
            |:.:|.|.:.|||..      |...||.:...:.|:.:.|             ::|.:.:..:||
Yeast   127 ALRDLFSKLLNLLKITYPMSTLKDVLFNWMNEILEVPSTL-------------RVQYYLIDALSS 178

  Fly   379 DTDSVRHMSSALLHQVLQHAQAAGQEELFQVVYRQ--FEDRA-AYLNASCMALEQLVAVAGVSKS 440
            |.|                        |:.::.::  |.|.: :.:|:..:|           .|
Yeast   179 DFD------------------------LYYIIEKKPHFIDNSFSLMNSDLLA-----------NS 208

  Fly   441 IENC-PSLFGVIFPRHLGCEDCVDALFKAMMVSAHKTEPFA-EWQSRWFGLLLAAIRVPEKRRQV 503
            :..| .||...|:.:|          ||       |.|.|. ||...|....|..|...:..:.:
Yeast   209 VGKCIVSLLLNIYEKH----------FK-------KNESFVQEWIQLWKSCALKYIHDKQYTKSI 256

  Fly   504 IEELIAQAVQLEPTRLAQVLL-----PDDRLPLS-CKLAAILGVRQ--LSARRQNLLRGMKEEVE 560
            ...::....:..|.....:.|     .|..|.|| .|:...||:.:  ....:...:..:.:.:|
Yeast   257 NLYIMIPLFKNMPNSAFTLFLECMSNKDPSLLLSLLKIGQELGIEEEPFCDNKYTTVDSVNKLIE 321

  Fly   561 QALIGLDDHTRLLALRFLVETPRPSELLNADQMGAIELYV-----------RHNANNPSAHL--- 611
            |      |..:|.....|..:.:.|:.:.......|:.|:           |:...:...|.
Yeast   322 Q------DEYKLQVFEILTFSTKKSKPIRPFVFKTIKQYLYVFFVDTELERRNYFCSSMKHFIFR 380

  Fly   612 -RQLGYGLLQKA--LKRVHFGLVEYRKSRTPASQEVLQFLIRLIRTLAQNLFPTANYGRRWLSLR 673
             |...|.|.:.|  ||:.. ...:.::.:....:|...||:.|...:..||.|...|.....||:
Yeast   381 TRDCAYSLARDARKLKKAE-KFPDEQREKLAQVEEARAFLVWLCNFIKYNLAPGTLYQANVTSLK 444

  Fly   674 LLRDCLE-----------------------LSEMVGITFSELGIELPTEALMACLGDSYEHNKVL 715
            |:...::                       :..:..:||..|.|:|    |::...|..|.:|
Yeast   445 LMHILIKSGVDKSTPQKFLDNQNKREYPFSIPILQDVTFLRLLIDL----LVSNYADVRELSK-- 503

  Fly   716 AAQLLERFQSHSLFKPDEMIELLLSLRPSDSATGAF-----QLQVYCKASRVQSEMPTPTHGGTI 775
                             ||:.:::|   :|.:.|.|     ...:...|:.:.|:......|.|:
Yeast   504 -----------------EMLFIMIS---ADESRGLFLDTLDANALKWTATSLLSDYEKGDAGATV 548

  Fly   776 HEPL-------------TFRALQWCLQHLR-EGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLK 826
            :|.:             |...|...:|:|: :.:..|:..:|..          ||:..|:.. |
Yeast   549 YEFIFTVMGSQRSFIDQTIDILAQMVQNLQNDSIGCAENSIGPH----------FAALSLILN-K 602

  Fly   827 LKELAKEPQWRQYIDELVTMCLAVSSVVLPVVSSASPEGHLPETCDQETDQPLTNVLDRQLSREE 891
            ...........:.|.:|:.:.|........||...|..|.||                     |:
Yeast   603 FNSEENHQDTSKIISKLINLVLKSWEATRNVVCHDSAHGILP---------------------EK 646

  Fly   892 LLQVRTTPQMILLCAWRSSKEVCLILGELVQRAPLEEEEDEEQQQQQGDFLLSRAQLEAIGEHFL 956
            ........|:|:..|:|:.||...:|..::::.|                 |:|.||::||:.|:
Yeast   647 YANCGVPDQVIISHAFRAIKEASYLLETILKKYP-----------------LTRDQLDSIGDLFI 694

  Fly   957 QLLAETKHRGAFEQAYVGFTMLCRRFWHSESVRLNQLPGQWVDEAMAMVSGQEEWAGKGARLCAT 1021
            ..|:..:|.|||:....|....|.|........|.:|..:.|...            |......|
Yeast   695 VQLSTIRHSGAFQAVLPGLKAFCIRCQLEFPAILEELLSKSVKSL------------KSKTQHIT 747

  Fly  1022 RRSAGMPFMLQALVGTELKLGTHATLYRCMNRLLEVCERRTGGAAGITARSH----------ALN 1076
            |||.|:||::..::..|:..| ...|.:....||.|        |.:....|          |:|
Yeast   748 RRSGGLPFLVTTVLSAEVTKG-RPLLQKTFENLLLV--------ARLPIPPHQDEFDLPQVNAIN 803

  Fly  1077 IMRALFRSSELAELVTEFMARGIQCAL---DGLLLAEEWAERNSATLLLAALIVRVFGVERARLE 1138
            .:.|:|...:|:...|.|::..::.||   |    .:.||.||.:.:|..:|..|:||
Yeast   804 CINAIFVEPKLSVHCTSFVSEALELALLNFD----CDIWALRNCSIMLFTSLQNRIFG------- 857

  Fly  1139 TGELHVRNRMTGRIFFTRYPQLFDYFHAALQRESEQMDAGGGGSENASGKRRQAVQLEAMLLMLS 1203
                .|...::.::|||:|..|.......|.....|.          ||..|::.|:|::.|:|:
Yeast   858 ----KVGRSVSAKLFFTKYSGLRQLLLNILNSSIAQY----------SGSERKSYQIESIFLVLN 908

  Fly  1204 ---RLYPSSLEGAESTLNLSEFVPFLIRICHSHDLMTREMAALVVANFVTQEQALAEIRRIVVEL 1265
               ||.|::     ....|.||...:.....:.:...|:||:.|:  .:..|....|||:: ::|
Yeast   909 VLLRLRPTA-----GYTGLKEFNVSVYECLSNENWKIRDMASRVL--HMLSENFEEEIRKL-LDL 965

  Fly  1266 KALQLRLKNTEAANTKLNTNVLHGQLLLLLHL 1297
            .::             ...|.|||.||.|..|
Yeast   966 ASI-------------AKQNQLHGHLLALQQL 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_608361.3	DUF2428	863..1112	CDD:313558	56/261 (21%)
TRM732	NP_013986.1	COG5543	1..1419	CDD:227830	212/1072 (20%)
		HEAT repeat	1154..1178	CDD:293787
		HEAT repeat	1189..1218	CDD:293787
		HEAT repeat	1224..1250	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346569
Domainoid	1	1.000	49	1.000	Domainoid score	I2959
eggNOG	1	0.900	-	-		E1_COG5543
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	1	1.000	-	-		oto100309
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	LDO	PTHR14387
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2009
SonicParanoid	1	1.000	-	-		X2730
TreeFam	0	0.000	Not matched by this tool.
	9	8.860