DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment THADA and THADA

DIOPT Version :9

Sequence 1:NP_608361.3 Gene:THADA / 33001 FlyBaseID:FBgn0031077 Length:1746 Species:Drosophila melanogaster
Sequence 2:NP_001077422.1 Gene:THADA / 63892 HGNCID:19217 Length:1953 Species:Homo sapiens


Alignment Length:2041 Identity:451/2041 - (22%)
Similarity:769/2041 - (37%) Gaps:542/2041 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LRVAALKVCAHP----KRFAELRDALVPLPNTWIAAPHDFVLQFAAAKSSAEQVQVVKDVF-YGE 65
            ::||||.:|...    |.||::....:.          ..:|..........|:..:|.:. ..|
Human     9 MQVAALTICHQDLETLKSFADVEGKNLA----------SLLLHCVQLTDGVSQIHYIKQIVPLLE 63

  Fly    66 QAQDH-----------EDVAHFLADLLLASPLKHAVRNQLTKL---FSDNALAKQNASPHRRHSK 116
            :|..:           :.:|.....|.|.:|||..:.:.|..|   |...|:       ||..|:
Human    64 KADKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASSLNSLPDFFLPEAM-------HRFTSR 121

  Fly   117 EHLLEALQQSLGEMANSLAVITPPVSHERTNDVFVSANACLQNFPFGREALG---KQVHRFAPLL 178
                  ||:.|.        .|...|:.:..|   :.::|::||..||.::.   |.|..|    
Human   122 ------LQEELN--------TTDLYSYRKVTD---NISSCMENFNLGRASVNNLLKNVLHF---- 165

  Fly   179 TTALERYWADI------CDPTLELSPTRRNELYLYVQNALRFLVSLLAEWSDKLRLFEDQRFPGT 237
               |::...:|      |.....:.....|:|.:.::.:: .||..:.::...|....|.  |..
Human   166 ---LQKSLIEILEENRKCAGNHIIQTQLMNDLLVGIRVSM-MLVQKVQDFQGNLWKTSDS--PIW 224

  Fly   238 SN-----AVAQKVARYYDTPWDVRSIAALLIGHLARFSGTFKAYVEDCSRPKAEQDVPIQMAALL 297
            .|     ::..||....|....|:|.:.|.|          ..:::....|  .:.:|..::::|
Human   225 QNMCGLLSIFTKVLSDDDLLQTVQSTSGLAI----------ILFIKTMFHP--SEKIPHLISSVL 277

  Fly   298 VLRPVDYTE-----------------NATLALAILKRIVAVSELKS-----TVTNLLVFLSKHLF 340
             ||.||.|.                 :.:..|.:.:..:|:.:.::     :...||:..:..||
Human   278 -LRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLF 341

  Fly   341 IYSKSLGEMHAHLPDDQKLLYQRILAQLQVFALQNISSDT------------------------- 380
            ..|..:.|      ...::...||||.....|:|.:.|.:                         
Human   342 TLSSQIKE------PTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHW 400

  Fly   381 ----DSVRHMSSALLHQVLQ--HAQAAGQE--------ELFQVVYR-QFEDRAAYLNASC----- 425
                |::||.:..:...:||  .....|.:        ||.:.:.| ::..:..|....|     
Human   401 EHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECI 465

  Fly   426 -----MALE-----QLVAVAGVSKSIENCPSLFGVIFPRHLGCEDCVDALFKAMMVSAHKTEPFA 480
                 :|::     |::.|.|....:.....|...:|..|                .:|.....|
Human   466 GVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNH----------------KSHLKSQTA 514

  Fly   481 E------WQSRWFGLLLAAIRVP--EKRRQVIEELIAQAVQLEPTRLAQVLL-----------PD 526
            |      |...|...||..:...  :::..||:..:.:.:...|..|..::.           .:
Human   515 ESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQE 579

  Fly   527 DRLPL--SCKLAAILGVRQLSAR--------------RQNLLRGMKEEVEQALIGLDDHTRLLAL 575
            ...|.  ||.....||......|              .:||:...:  ::|.||......|:..|
Human   580 QSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDAR--IKQGLIHQHCQVRIDTL 642

  Fly   576 RFLVETPRPSELLNADQMGAIELYVRHNANNPSAHLRQLGYGLLQKALKRVH------FGLVEYR 634
            ..|.|:.|.:|:::.::|..|:.::.:|.|:.|..:||....||:|...|:.      :.|.:.:
Human   643 GLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSK 707

  Fly   635 KSRTPAS-----------QEVLQFLIRLIRTLAQNLFPTANYGRRWLSLRLLRDCLELSEMVG-- 686
            ..|.|.:           |:...|:..:..:|.:.|||.::|..|:.:|.:|....|:..:..  
Human   708 SKREPENELTKQHPSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGR 772

  Fly   687 -ITFSELGIELPT---EALMACLGDSYEHNKVLAAQLLERFQSHSLFKPDE---------MIELL 738
             .|..:|..::..   :.||.|...::|..|:||..||.:....::...|.         .:||.
Human   773 IYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELS 837

  Fly   739 LSLRPSDSATGAFQL-------------------QVYCKASRVQSEMPTPTHGGTIHEPLTFRAL 784
            .|.:|.|..|.::.|                   ||.|.    ..:.|     ..:.|..|...:
Human   838 TSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACD----NGDRP-----AAVVERNTLMVI 893

  Fly   785 QWCLQHLREGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLKLKELAKEPQWRQYIDELVTMCLA 849
            :..:::|.|.:..|:..|.:||...|:||.:......||:|.|..|....:||..:::|:.|...
Human   894 KCLMENLEEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYR 958

  Fly   850 VSSVVLPVVSSASPEGHLPETCDQETDQPLTNVLDR----------------------------- 885
            :|:||.||:.|:||||.:|...|.|:...|..:|:.                             
Human   959 LSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNA 1023

  Fly   886 ---------QLSREELLQVRTTPQMILLCAWRSSKEVCLILGELVQRAPLEEEEDEEQQQQQGDF 941
                     ::..:|:.....|.||:|:|.|||.|||.|:||.|.|..|:      :...:..|.
Human  1024 SVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPM------QPVPESSDG 1082

  Fly   942 LLSRAQLEAIGEHFLQLLAETKHRGAFEQAYVGFTMLCRRFWHSESVRLNQLPGQWVDEAMAMVS 1006
            ||:..|::.||::|.|.|.:::||||||.||.||..|........:|.|.:||.||:...:..: 
Human  1083 LLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEI- 1146

  Fly  1007 GQEEWAGKGARLCATRRSAGMPFMLQALVGTELKLGTHATLYRCMNRLLEVCERRTGGAAGITAR 1071
               :.:...::|||||||||:||.:|||:.:|.|.|....|...|..|:.:. ..|........:
Human  1147 ---KCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLA-GPTDDIQSTVPQ 1207

  Fly  1072 SHALNIMRALFRSSELAELVTEFMARGIQCALDGLLLAEEWAERNSATLLLAALIVRVFGVERAR 1136
            .|||||:|||||.:.|.|.:..::|.|.:.|:.| ..:..||.|||:|||.:|||.|:|||:||:
Human  1208 VHALNILRALFRDTRLGENIIPYVADGAKAAILG-FTSPVWAVRNSSTLLFSALITRIFGVKRAK 1271

  Fly  1137 LETGELHVRNRMTGRIFFTRYPQLFDYFHAALQRESEQMDAGGGGSENASGKRRQAVQLEAMLLM 1201
            .|..:   .||||||.||:|:|:|:.:....|:..:..:|     |:.....|..::.|  :||:
Human  1272 DEHSK---TNRMTGREFFSRFPELYPFLLKQLETVANTVD-----SDMGEPNRHPSMFL--LLLV 1326

  Fly  1202 LSRLYPSSLEGAESTLNLSEFVPFLIRICHSHDLMTREMAALVVANFVTQEQALAEIRRIVVELK 1266
            |.|||.|.::|..|.|::..||||::|..||....:|||||..:..||..:.....||.::..|.
Human  1327 LERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLP 1391

  Fly  1267 ALQLRLKNTEAANTKLNTNVLHGQLLLLLHL--------HRLVRWTRPSLTRMQLHTLAELAAPL 1323
            :         ..:.....|.:||.||.:.||        |......:..||.:.:.|.|:|....
Human  1392 S---------CTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAK 1447

  Fly  1324 LQHDACAFSALVAVMVAAMEDAVEPGLLDFQLLEQIGVVYLL------NHKEVQSRCQQLGISNR 1382
            .|:......|:                       .|.:::||      :.|:.|...:.||    
Human  1448 RQNPCLVTRAV-----------------------YIDILFLLTCCLNRSAKDNQPVLESLG---- 1485

  Fly  1383 FYQIFGLHLHRLRGISQGIVL--------------HIVEDLAE----TIWAL------DELKVEL 1423
            |::       .:|||..|..|              ..::.|..    .:||.      .|..|.:
Human  1486 FWE-------EVRGIISGSELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPI 1543

  Fly  1424 WLYILLQRSLSEQNSLVSEQDIEHFEFSR-------------DIRRYFETLSREQREEVGQELYE 1475
            ....||:.:..|..||..|..:|.|..:.             ::...|..|:.::..        
Human  1544 SFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENH-------- 1600

  Fly  1476 SPAVRSSVLHMMHMIKSSK-----NSC----------WSLQLAG--RLAALQTLLRDPGLELNQL 1523
             |.....:|.::|.:...:     ..|          |::.:|.  |.......||.....::..
Human  1601 -PECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHH 1664

  Fly  1524 VQRCSEEHSTHQEAGLLLGLRRLIGESKMLERKHWLPM--------LNYAQRL-----VHPGQPV 1575
            :|.|.|.             |.||.    .|.|.|:.:        |....||     :....|:
Human  1665 MQTCVEN-------------RELIA----AELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPL 1712

  Fly  1576 YLR--HQAAELCDSLARNHLRDQLVAGTTDVDIGLVGRFSGLVLLLLHDDAEWVRHRAVQLVCGA 1638
            :|.  |...||.|:||                      ....||.||..:.:.||..|.:.|..|
Human  1713 FLTNPHPILELQDTLA----------------------LWKCVLTLLQSEEQAVRDAATETVTTA 1755

  Fly  1639 GLRTRSGAGQEQEQS----------AMAPLILPSAL-----IPPFLDTMIGKLTFDDFNMVQRLV 1688
              .::....|..|.:          |:|..:|...|     :.|.|..::|.|..:..::|    
Human  1756 --MSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLV---- 1814

  Fly  1689 DIIAEPFTTADAMELFDKQENNHYCE 1714
             ...|.....:...||:|.|.|.:.|
Human  1815 -ACVESMHQVEEDYLFEKAEVNFWAE 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
THADANP_608361.3 DUF2428 863..1112 CDD:313558 89/286 (31%)
THADANP_001077422.1 DUF2428 952..1247 CDD:287339 115/294 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159862
Domainoid 1 1.000 149 1.000 Domainoid score I4460
eggNOG 1 0.900 - - E1_COG5543
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D18527at33208
OrthoFinder 1 1.000 - - FOG0002253
OrthoInspector 1 1.000 - - oto91638
orthoMCL 1 0.900 - - OOG6_102243
Panther 1 1.100 - - O PTHR14387
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2730
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.710

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