Protein Alignment THADA and si:ch211-225b11.4

DIOPT Version :9

• Sequence 1: NP_608361.3
• Gene: THADA / 33001
• FlyBaseID: FBgn0031077
• Length: 1746
• Species: Drosophila melanogaster
• Sequence 2: XP_005165257.1
• Gene: si:ch211-225b11.4 / 561626
• ZFINID: ZDB-GENE-060526-114
• Length: 1849
• Species: Danio rerio
• Alignment Length: 1966
• Identity: 421/1966 - (21%)
• Similarity: 707/1966 - (35%)
• Gaps: 565/1966 - (28%)

  Fly    71 EDVAHFLADLLL----ASPLKHAVRNQLTKLFSDNAL-----------------------AKQNA 108
            ||....|..::|    :|.:|..:|:.|.||..:..:                       |..:.
Zfish     9 EDADAVLKSVVLEDQFSSDVKDTLRSFLLKLTENGRITGKRSRDRSLEEASQILQKIPKEALHSL 73

  Fly   109 SPHRRHSKEHLLEALQ----------QSLGEMANSLAVITPPVSHERTNDVFVSANACLQNF--- 160
            .|...|....|:.|||          :.|.:|....|||...|       ||.....||.|.
Zfish    74 QPPALHRLIQLILALQLEAVTTSSACRKLDQMLQVFAVINHSV-------VFEEVKQCLLNILHQ 131

  Fly   161 -------------------PFGREA--------LGK-----------QVHRFAPLLTTALERYWA 187
                               ..|||.        |||           :..|..||....::.
Zfish   132 KQVFSLKDLQIICMFLEDSTIGREVLKSECTTLLGKVAELIPVVMSDEASRNGPLCYQMVKG--- 193

  Fly   188 DICDPTLELSPTR-------RNELYLYVQNALRFLVS-LLAEWSDKLRLFEDQRFPGTSNAVAQK 244
              |....:|.|..       ::.:.:..:..|.||:. :|.|.|.:    :.:...||  |||..
Zfish   194 --CLQVFQLLPGEVAQLVYSKDSVNITARGILEFLMRIILGEVSSR----DTRLLAGT--AVAML 250

  Fly   245 VARYYDT------PWDVRSIA-----ALLIGHLARFSGTFKAYVEDCSRPKAEQDVPIQMAALLV 298
            ::...|:      .|.:..|.     .|.:|.|.          .:|| .:.:..|.    .|.|
Zfish   251 LSTATDSQCAGSAAWSLLQITKTEPWRLTVGELQ----------VNCS-SRCQDGVD----RLAV 300

  Fly   299 LRPVDYTENATLALAILKRIVAVSELKSTVT-----NLLVFLSK--------HLFIYS------K 344
            .|.:         |...|..|.||...:..|     .||.|:|.        |.|::.      |
Zfish   301 CRGL---------LTCCKNDVLVSRHSNQKTCFLLHGLLPFISALCEEKLDCHYFVFQVFTIWLK 356

  Fly   345 SLGEMHAHL------PDDQKLLYQRILAQLQVFALQNISSDTDSVRHMSSA---LLHQVLQ-HAQ 399
            .|.|..:.:      |.|..|  |..|.|:   ..:|..|..|.|..::.:   |..::.: ..|
Zfish   357 RLKECLSEVWEVTGAPLDSDL--QHRLTQI---IWRNSESPLDGVAEVARSAFCLFMEIYEKDCQ 416

  Fly   400 AAGQEE------LFQVVYRQFEDRAAYLNASCMALEQLVAVAGVSKSIENCPSLFGVIFPRH-LG 457
            ..|.|:      |.::....:|.:|.||     .|..::...|.:|.:|..|:|     |.| |.
Zfish   417 HFGTEKSLYVELLKRISELPWESKAKYL-----PLTAVLPYTGTNKVLELYPAL-----PYHLLK 471

  Fly   458 C------EDCVDALFKAMM--------VSAHKTEP------FAEWQSRWFGLLLAAI--RVPEKR 500
            |      ..|...::|:::        :.|.|..|      ..:|..:|..::|.|:  .:...:
Zfish   472 CLSTNHLSPCASEVYKSLLQEQKRELIIIASKEAPPTDQYLANQWAHQWQPVILEALTSEITLLQ 536

  Fly   501 RQVIEELIAQAVQLEPTRLAQVL------LPDDRLPLSCKLAAILGVRQLSARRQNLLRGMKEEV 559
            ......|:...::..|.....:|      .|......:|.::|     |.:...::|.......|
Zfish   537 NNASSHLLPTTLRTFPGAFNTLLSALNPSAPGHLHAWACVMSA-----QRATSGRSLWGAESSHV 596

  Fly   560 EQ----ALIGLDDHTRLLALRFLVETPRPSELLNADQMGAIELYVRHNANNPSAHLRQLGYGLLQ 620
            .|    ||..|||..||.||..|..:|:.:|..:..:..|:..::..|.|..|:..||.....|:
Zfish   597 HQTLHLALCSLDDSVRLAALNLLCCSPKTNEAPSQLEYSALRDFIPLNLNCESSPFRQHLQAALR 661

  Fly   621 KALKRVH---FGLVEYRKSRTPASQEV-------LQFLIRLIRTLAQNLFPTANYGRRWLSLRLL 675
            |.|.|:.   ..:::.|.|:...::|.       ::|:..|.:.....|.|.::|.|:...|.||
Zfish   662 KFLVRIRDSCMAIIKGRNSKKGLTEEEVAEIEQGVEFVEWLFQLSLVYLSPDSSYQRKKTVLLLL 726

  Fly   676 RDCLE------------------LSEMVGIT--------FSELGIELPTEALMACLGDSYEHNKV 714
            ...||                  :|.::...        ||:..:.:    |:.||.||....:.
Zfish   727 CAVLETCTDTWSPDRKKGQPPANMSTLINWAKDRGKWDFFSKSKLLV----LIGCLEDSTNEIRE 787

  Fly   715 LAAQLLERFQSHSLFKPDEMI--------ELLLSLRPSDSATGAFQLQVYC-KASRVQSEMPTPT 770
            |:|:||.||...||  ||::.        :||.|.|..::..||..:::.. ||..|.::
Zfish   788 LSAELLFRFFPSSL--PDDVTCVLFSRADQLLQSPRVQEAQMGALMVKLLLQKADGVFNQ----- 845

  Fly   771 HGGTIHEPLTFRALQWCLQHLREGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLKLKELAKEPQ 835
                 .|..:.:.:.:.|..|.:....|:.|:..||:..|::|::.|.:..|  |::..:..|..
Zfish   846 -----GEKQSVKLITFLLSKLEQHYLTARSDMLLAARTTPVHGIVSALQRGL--LEVPGVLLESI 903

  Fly   836 WRQYIDELVTMCLAVSSVVLPVV--SSASPEGHLPET-CDQETDQPLTNVLDRQLSR-------- 889
            ......|||.:...::.|:|.|:  :..:.|..:|.: ||      :.|.:...:.:
Zfish   904 THSIAGELVLLLEKLTLVLLGVLYGNQDTEEKDVPPSFCD------MGNAISSLIGQGGVDGVGL 962

  Fly   890 ----EELLQVRTTPQMILLCAWRSSKEVCLILGELVQR-APLEEEEDEEQQQQQGDFLLSRAQLE 949
                ||.:.:.....::|.|.|.|.||:.:.||.||:| ..|..||          ..||..:|.
Zfish   963 DEDGEENVLLSEEHSLVLTCCWVSLKEIGIFLGSLVERILSLHCEE----------LKLSVEELR 1017

  Fly   950 AIGEHFLQLLAETKHRGAFEQAYVGFTMLCRRFWHSESVRLNQLPGQWVDEAMAMVSGQEEWAGK 1014
            ...:.|..::.:.:|.||.|...||||..||....|....:.|:|...:.:.::::......:
Zfish  1018 TASKVFKDIILKCRHWGAVEGCCVGFTKFCRALLSSSDPDIRQIPSLMLQQGLSVLQSPSSTS-- 1080

  Fly  1015 GARLCATRRSAGMPFMLQALVGTELKLGTHATLYRCMNRLL------------------EVCERR 1061
                 .|||:||:|.::..::..|....:...|...:|.||                  :||
Zfish  1081 -----VTRRAAGLPMLILGVLAAEDSSKSRPLLAHTINTLLDTAKALLPSDWDQTLDLPQVC--- 1137

  Fly  1062 TGGAAGITARSHALNIMRALFRSSELAELVTEFMARGIQCALDGLLLAEEWAERNSATLLLAALI 1126
                        |::.::||.:.|.|...|.:|.......:|. ||.:..||.||:|..|.::|.
Zfish  1138 ------------AVHTLQALVKGSSLGVAVLQFTPAMAVLSLT-LLSSACWAMRNAALQLYSSLC 1189

  Fly  1127 VRVFGVERARLETGELHVRNRMTGRIFFTRYPQLFDYFHAALQRESEQMDAGGGGSENASGKRRQ 1191
            .|:.|.::|    ||....:.|:...||..||.|..:...||:..:..:.
Zfish  1190 TRMLGQQKA----GEGSSNSGMSAASFFHLYPALQPFLQGALETAANDLH--------------- 1235

  Fly  1192 AVQLEAMLLMLSRLYP-----SSLE-GAE-STLNLSEFVPFLIRICHSHDLMTREMAALVVANFV 1249
                :|.||:...|||     |.|: ||| .|..||||:|.|:.:..|.....|.|::..:...:
Zfish  1236 ----DATLLLHPALYPVLTLLSKLQPGAEKQTRALSEFLPPLLLLSASPVYGVRVMSSKALVAMI 1296

  Fly  1250 TQEQALAEIRRIVVELKALQLRLKNTEAANTKLNTNVLHGQLLLLLHLHRLVRWTRPSLTRMQLH 1314
            ...:.:|.:.::|.:|         .|:.:.....|.|||:||....:  |.|..|.|::.:.|.
Zfish  1297 PTSEYMATVLQLVKDL---------PESPDVVSCHNRLHGKLLQTRAI--LTRALRSSVSSLSLS 1350

  Fly  1315 TLAEL------------AAPLLQ------------HDACAF-SALVAVMVAAME---DAVEPGLL 1351
            .:.::            ..||::            |.:..| |.|.:.::..::   |.:|.|..
Zfish  1351 EVVDVFESRLWLGSSKQRCPLVRQSYVDIVRLIRGHCSAGFLSQLSSQLLHEIQRTPDILEIGAA 1415

  Fly  1352 DFQLLEQIGVVYLLNHKEVQSRCQ---QLGISNRFYQIFGLHL-------HRLRGISQGIVLHIV 1406
            .|   .|..|.:|....|  ..||   .|...|...|   |.|       |..||
Zfish  1416 SF---HQSTVNFLCGDPE--WACQAWRSLANGNAVVQ---LSLVKSVTDGHGWRG---------- 1462

  Fly  1407 EDLAETIWALDELKVELWLYILLQRSLSEQNSLVSEQDIEHFEFSRDIRRYF-----ETLSREQR 1466
            .||.:.|..  |||..|            :.:|:|:        |.|.|..:     |.|:.|:
Zfish  1463 TDLQQVIEG--ELKANL------------KAALMSQ--------SVDYRAAYLTALVEVLTPEE- 1504

  Fly  1467 EEVG-----QELYESPAVRSSVLHMMHMIKSSKNSCWSLQLAGRLAALQTLLRDPGLELNQLVQR 1526
            |.:|     ...:|...::..|..:::.:::.:.....:..|  |.|:..|| ....:::.|.:.
Zfish  1505 ESLGLSRLCPSEFEQTGLQECVELLLNDLETDRGGPALISTA--LCAVSVLL-SQSADVSFLQRW 1566

  Fly  1527 CSEEHSTHQEAGLLLGLRRLIGESKMLERKHWLP------MLNYAQRLVHPGQPVYLRHQAAELC 1585
            |                       |:|| ||..|      ....||.|...|..|..|    .|.
Zfish  1567 C-----------------------KLLE-KHRCPDAPEALRSACAQSLCLCGVSVVTR----SLT 1603

  Fly  1586 DSLARNHLRDQLVAGTTDVDIGLVGRFSGLVLLLLHDDAEWVRHRAV----QLVCGAGLRTRSGA 1646
            .||...||...|::             :|  |.||.|::..||.:|.    .|.|..........
Zfish  1604 SSLIPKHLNTSLIS-------------TG--LFLLQDESSDVRAKAAIFASLLCCSRQPEAPQRC 1653

  Fly  1647 GQEQEQSAMAPLILPSALIPPFLDT------MIGKLTFDDFNMVQRLVDIIAEPFTTADAMELFD 1705
            ...|...|:..|:  ..|:..|.||      ::..|...|.|       ||.:.........|::
Zfish  1654 FHMQVNQALRSLL--DLLLEEFWDTSGALEALLCHLPSCDLN-------IILKQAKDTQCRSLYE 1709

  Fly  1706 KQENNHYCERNHVLTE 1721
            ..|.|.:.|.: |::|
Zfish  1710 PDEANVFAEPS-VISE 1724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_608361.3	DUF2428	863..1112	CDD:313558	61/280 (22%)
si:ch211-225b11.4	XP_005165257.1	DUF2428	958..1175	CDD:287339	56/249 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D18527at33208
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	LDO	PTHR14387
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920