DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THADA and SPCC1494.07

DIOPT Version :9

Sequence 1:	NP_608361.3	Gene:	THADA / 33001	FlyBaseID:	FBgn0031077	Length:	1746	Species:	Drosophila melanogaster
Sequence 2:	NP_588532.1	Gene:	SPCC1494.07 / 2539238	PomBaseID:	SPCC1494.07	Length:	1502	Species:	Schizosaccharomyces pombe

Alignment Length:	1594	Identity:	341/1594 - (21%)
Similarity:	571/1594 - (35%)	Gaps:	440/1594 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 IYSKSLGEMHAHLPDDQKLLYQRILAQLQVFALQNISSD--TDSVRHMSSALLHQVLQHAQAAGQ 403
            ::||||            .||      |.|...::|.:|  .||::|    .||.
pombe   131 VFSKSL------------QLY------LLVCPSEDIKNDFLLDSLKH----ALHW---------- 163

  Fly   404 EELFQVVYRQFEDRAAYLNASCMALEQLVAVAGVSKSIENCPSLFGVIFPRHLGCEDCVDAL--- 465
                        ||.|  ...|.|::.||.|.|........|..|          |..:..|
pombe   164 ------------DRHA--KVVCTAIQLLVKVTGAEAVFAFQPDFF----------EQSLKLLKDY 204

  Fly   466 -----------------FKAMMVSAHKTEPFAE----WQSRWFGLLLAAIRVPEKRRQ--VIEEL 507
                             ||::   :.:||...|    |.:.|..::|......:::.|  :...|
pombe   205 SYAQAISSTILTVLTLRFKSL---SEETEDREEVETKWMNIWCPIILYEFYGNDRQVQAGMSSFL 266

  Fly   508 IAQAVQLEPTRLAQVL--------LPDDRLPLSCKLAAILGVRQLSARRQNLLRGMKEEVEQALI 564
            |...:.:.|....:.|        :..|....:|..|..:      |:...:::.:....|.|.:
pombe   267 IPSLLGVSPGITVKFLSRLQNYPNVSKDARDAACLYALKI------AKDSKIIKNLDLVKEHAFV 325

  Fly   565 GL-----DDHTRLLALRFLVETPRPSELLNADQMGAIELYVRHNANNPSAHLRQLGYGLLQKALK 624
            ..     |...:|...|.:...|..|..|:.:....:|..:..:.|......||:       .||
pombe   326 KTLFKHPDIKIQLACFRLIALCPNVSSPLSFEDFDCLESNIEFSFNVLDPDSRQI-------LLK 383

  Fly   625 RVHFGLVEYRKS-----RTPASQ------------EVLQFLIRLIRTLAQNLFPTANYGRRWLSL 672
            .:....:..|.|     ||..|:            ..:|||...|....::|:||.||.:..:||
pombe   384 SMQDFFIRLRASCHSIARTMRSRHSDKVALSGLLDRAMQFLTSFISVCKKHLYPTCNYQQVLVSL 448

  Fly   673 RL--------LRDCLELSEM----VGITFSELGIELPTEALMA-CLGDSYEHNKVLAAQLLERFQ 724
            ..        |.|.:|.|.:    ....||.:.|:.....||. .|.|.|:..:.|..::|..::
pombe   449 SFLDTLISFGLDDNVESSSIREAQHDFPFSMVIIDRDLSRLMIDRLKDPYDDIRNLCLKILLSYK 513

  Fly   725 --------SHSLFKPDEMIELLLSLRPSDSATGAFQLQVYCKASRVQSEMPTPTHGGTIHEPLTF 781
                    |.:.|..:..:|||.::|..:...||  ..:|.....::..:|......|
pombe   514 SLPGFISDSDAYFLFNHGLELLNAVRSHECDGGA--KTIYLCNHFMEKSVPGSVLANT------- 569

  Fly   782 RALQWCLQHLREGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLKLKELAKEPQ-WRQYIDELVT 845
               :..|..|:..:..|:..|.|||...||.|.|....::.|.|....:..:.: |:..:.||:.
pombe   570 ---KVILNRLKSNIEHAKTSLLEAAVNCPLQGYLIQLTYIFQSLSPTIVKNDNESWKNIVMELIK 631

  Fly   846 MCLAVSSVVLPVVSSASPEGHLPETCDQETDQPLTNVLDRQLSREELLQVRTTPQMILLCAWRSS 910
            ....:..::..|:...||||:||   |.|.:..:.:.|:           .|..|:||..:|||.
pombe   632 ASETIWGLIKDVLCDDSPEGNLP---DGEGEGGIVSNLE-----------DTPAQLILSYSWRSL 682

  Fly   911 KEVCLILGELVQRA-PLEEEEDEEQQQQQGDFLLSRAQLEAIGEHFLQLLAETKHRGAFEQAYVG 974
            ||...:|..|:.:. .|.:||            .:...|...||..:..|.|.:|||||...|..
pombe   683 KETSSLLTVLLTKCLSLFDEE------------FTPFTLNYYGELMMTWLWEIRHRGAFTSVYPC 735

  Fly   975 FTMLCRRFWHSESVRLNQLPGQWVDEAMAMVSGQEEWAGKGARLCATRRSAGMPFMLQALV---- 1035
            |...|...:......:::||..|:.:.::::..:..:        .||||.|:|..:.|::
pombe   736 FIEYCSFLFECNKHEISELPDPWLHKNLSVIQEKSSF--------ITRRSGGIPLSITAILVAGK 792

  Fly  1036 --GTELKLGTHATLYRCMNRLLEVCERRTGGAAGITARSHALNIMRALFRSSELAELVTEFMARG 1098
              ..:|...|..:|.....:.:|  ::...|...: .:.||:|.::.:|....|:.:..|::...
pombe   793 DKREQLIEQTVISLISIAKQPVE--QKNIAGQFDL-PQVHAMNTLKTIFTEHRLSSVSVEYLEPA 854

  Fly  1099 IQCALDGLLLAEEWAERNSATLLLAALIVRVFGVERARLETGELHVRNRMTGRIFFTRYPQLFDY 1163
            |..:::| ...|.|..||.:.:|..|||.|.||.::.: :...|.....::.::||:::|.|.||
pombe   855 IALSIEG-FSHELWPIRNCSVMLFTALINRAFGSKKPK-DAVNLGNNKGLSTKMFFSKFPTLHDY 917

  Fly  1164 FHAALQRESEQMDAGGGGSENASGKRRQAVQLEAMLLMLSRLYPSSLEGAEST-LNLSEFVPFLI 1227
                |.||.|...|      :.|...:.:..|..:|.|.|||..:...|.|:. ..||:|.|.:.
pombe   918 ----LLRELEVSVA------SLSSNDQPSTGLYPILNMFSRLQYAQPYGNENEWTGLSQFEPLIF 972

  Fly  1228 RICHSHDLMTREMAALVVANFVTQEQALAEIRR----IVVELKALQLRLKNTEAANTKLNTNVLH 1288
            :...|.....||:|:|.:.       .|.:..:    ||.:||.:           ..|..|.:|
pombe   973 KCTASRICKVREIASLSLT-------CLLDCSKMTTFIVSQLKGV-----------AGLQQNEIH 1019

  Fly  1289 GQLLLLLHLHRLVRWTRPSLTRMQLHTLAELAAPLLQHDACAFSALVAVMVAAMEDAVEPGLLDF 1353
            |:||.:               |..|              :|.||.|....|....:.|....::.
pombe  1020 GKLLTI---------------RAVL--------------SCFFSKLTLQQVQEFYEVVPLAFINC 1055

  Fly  1354 QL---------------LEQIGVVYLLNHKEVQSRCQQL-----------------GISNRFYQI 1386
            .|               ||.:...::.|......|.|||                 .::|.|..|
pombe  1056 FLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCKRMLLDRKANVTNVFNTI 1120

  Fly  1387 FGLHLHRLRGISQGIVLHIVEDLAETIWALDELKVELWLYILLQRSLSEQNS---LVSEQDIEHF 1448
             ||.:|              :.:|.||: |:.|| |..:|       .:.:|   |||:  :.|:
pombe  1121 -GLPIH--------------QQMAATIF-LENLK-EFSVY-------CDAHSIGFLVSK--LLHY 1159

  Fly  1449 EFSRDIRRYFETLSREQREEVGQELYESPAVRSSVLHMMHMIKSSKNSCWSLQLAGRLAAL---- 1509
            ||.........::....|:::   :..:|.:      :..:||.:..:.||...|..|:.|
pombe  1160 EFYEVQLTTLRSIVDSPRKKI---IVNNPEI------LQALIKLTPRNQWSQVRALALSLLSDSL 1215

  Fly  1510 -QTLLRDPGLELNQLVQR-CSEEHSTHQEAGL-LLG--LRRLIGESKMLERK----HWLP-MLNY 1564
             .|..|..|:..:.:|.. .|.|....:|:.: |||  :::|..|: .||.|    .|:. :|:|
pombe  1216 NSTSYRLLGISCSDMVSNILSNECLPIKESFIVLLGSCIKQLKTEN-FLEYKVTFAKWVEILLSY 1279

  Fly  1565 AQRLVHPGQPVYLRHQAAELCDSLARNHLRDQLVAGTTDVDIGLVGRFSGLVLLL---LHDDAEW 1626
            :...    ||...|..|   .||:.  |. |...|.:|......  .|..|.|||   |:||.|.
pombe  1280 SNEY----QPFSSRKAA---LDSII--HF-DLFNAESTAEAFSF--EFYILYLLLGDFLNDDDEE 1332

  Fly  1627 VRHRAVQ---LVCGAG------------LRTRSG-AGQEQEQSAM-APLILPSA--LIPPFLDTM 1672
            :|..|..   .|.|..            |||::. .||...|..: ..|||...  |....||..
pombe  1333 IRSLAANHAYQVLGTSAQCVTEIWNLWKLRTKATFGGQHDFQHCINKRLILEDGCELASVQLDNA 1397

  Fly  1673 IGKLTFDDFNMVQRLVDIIAEPFTTADAMELFDKQENNHYCERNHVLTEL-------------WD 1724
            :.:                        ...||:::..|.|...|..|.:|             |.
pombe  1398 LSR------------------------NCSLFERERQNLYYSDNQKLEDLLFYASYPNEKLKDWA 1438

  Fly  1725 ARG------------RADPRARTPTIPTGYQIFK 1746
            ..|            |..|..:|......:.|:|
pombe  1439 TDGINAILSRFEDVSRDGPLGKTSDPNVWFTIYK 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_608361.3	DUF2428	863..1112	CDD:313558	59/255 (23%)
SPCC1494.07	NP_588532.1	COG5543	2..1502	CDD:227830	341/1594 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	65	1.000	Domainoid score	I2846
eggNOG	1	0.900	-	-		E1_COG5543
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	1	1.000	-	-		oto102078
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	LDO	PTHR14387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2009
SonicParanoid	1	1.000	-	-		X2730
TreeFam	1	0.960	-	-
	10	9.800