Protein Alignment THADA and Thada

DIOPT Version :9

• Sequence 1: NP_608361.3
• Gene: THADA / 33001
• FlyBaseID: FBgn0031077
• Length: 1746
• Species: Drosophila melanogaster
• Sequence 2: NP_898842.2
• Gene: Thada / 240174
• MGIID: 3039623
• Length: 1938
• Species: Mus musculus
• Alignment Length: 2018
• Identity: 458/2018 - (22%)
• Similarity: 779/2018 - (38%)
• Gaps: 506/2018 - (25%)

  Fly     6 LRVAALKVCAHP----KRFAELRDALVPLPNTWIAAPHDFVLQFAAAKSSAEQVQVVKDVFYGEQ 66
            ::||||.||...    :.||::....:.          ..:|..........|:..:|.:....:
Mouse     9 MQVAALTVCHQDMETLRSFADMEGKNLA----------SLLLHCVQLTDGVSQIHSIKQIVPLLE 63

  Fly    67 AQDHEDV------------AHFLADLLLASPLKHAVR---NQLTKLFSDNALAKQNASPHRRHS- 115
            ..|...|            |.....|.|.:|||..:.   |.|.::|...|          .||
Mouse    64 KVDKNGVCDPAIQSCLDILAGIYFSLTLKNPLKKVLASSLNGLPEVFLTQA----------THSF 118

  Fly   116 KEHLLEALQQSLGEMANSLAVITPPVSHERTNDVFVSANACLQNFPFGREA---LGKQVHRFAPL 177
            ..||.|.|..:            ...|:.:..|   :.::|::||..||.:   |.|.|..|
Mouse   119 TFHLQEELDTA------------DLYSYRKVMD---NISSCMENFNLGRASVVNLLKDVLHF--- 165

  Fly   178 LTTALERYWADICDPTLELSPTR--RNELYLYVQNALRFLVSLLAE--------WSDK------- 225
                |::...:|.:...:.:..|  :.:|...:...:|..::|:.:        |:|.
Mouse   166 ----LQKSLIEILEENRKFAGNRIVQTQLMSDLLVGVRVAMTLVQKVQGPQGSLWNDSSSPIWQS 226

  Fly   226 ----LRLF------------------------------EDQRFPGTSNAVAQKVARYYDTP-WDV 255
                |.:|                              ..::.||..:::..:.|.....| |.:
Mouse   227 MCGLLSIFTKFLNDDDLLQTVESTSGLAVILFIKTMFRPSEKLPGLISSLLLRSAECTSIPEWLM 291

  Fly   256 RSIAALLIGHLARFSGTFKAYVEDCSRPKAEQDVPIQMAALL---VLRPVDYTENA--TLALAIL 315
            .|..:|.                 |:      |||......|   .|..:|:.:.:  ....|:|
Mouse   292 NSCRSLC-----------------CT------DVPASTLLFLCQGTLAMLDWQDGSMGPSGEALL 333

  Fly   316 KRIVAV-----SELKSTVTNLLVFLSKHLFIYSKSL--------GEMHAHLPDDQKLLYQRILAQ 367
            ..||.|     |::|.:..::  |||:.|..::.|.        ..:..||..| ..:.:|:|.
Mouse   334 LDIVHVLFTLSSQIKESTLDM--FLSRILASWTSSAIQILESGSSGLKGHLNGD-SCVPRRLLE- 394

  Fly   368 LQVFALQNISSDTDSVRHMSSALLHQVLQHAQAAGQ--------------EELFQVVYRQFEDRA 418
               :...:.....|::||.:..:...:||..:...:              :.|.|:   ::..:.
Mouse   395 ---YVYTHWEHPLDALRHQTKVMFRNLLQMHRLTMEGADLATDPFCLELTKSLLQL---EWHIKG 453

  Fly   419 AYLNASC----------MALE-----QLVAVAGVSKSIENCPSLFGVIFPRHLGCEDCVDALFKA 468
            .|....|          :|::     |::.|.|....:.....|...:|..|           |:
Mouse   454 KYACLGCLVETLGIEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFKNH-----------KS 507

  Fly   469 MMVSAHKTEPFAE-WQSRWFGLLLAAI--RVPEKRRQVIEELIAQAVQLEPTRLAQVL----LPD 526
            .:.|...|..:.: |...|...:|:.:  ...::|..||:..:.:.:...|..|..::    ...
Mouse   508 HLKSQTVTNTWMDKWHETWVFPVLSVLCGGNLDQRSYVIDYYLPRILNYSPESLHYMVHILQAST 572

  Fly   527 DRLPLSCKLAAILGVRQLSARR--------------QNLLRGMKEEVEQALIGLDDHTRLLALRF 577
            |....||.....||......|.              :||:  ....|:|.||......|:..|..
Mouse   573 DTGTGSCNHRGALGALMACLRTARAHGHLQSATQAWENLV--CSARVKQGLIHQHCQVRIDTLGL 635

  Fly   578 LVETPRPSELLNADQMGAIELYVRHNANNPSAHLRQLGYGLLQKALKRVH-----FGLVEYRKSR 637
            |.|:.|.:|:::.::|..::.::.:|.|:.|..:||....||:|...|:.     ...:|.|||
Mouse   636 LCESNRSTEVVSTEEMQWVQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQRKS- 699

  Fly   638 TPAS-------------QEVLQFLIRLIRTLAQNLFPTANYGRRWLSLRLLRDCLEL---SEMVG 686
            ||.|             |:...|:..:...|.:.|||.::|..|:.:|.:|....|:   .|...
Mouse   700 TPDSENGSIREQPSVTLQQYKNFMSSVCNILFEALFPGSSYSTRFSALTILGSVAEVFPDPEGNI 764

  Fly   687 ITFSELGIELPT---EALMACLGDSYEHNKVLAAQLLERFQS------------HSLFKPDEMIE 736
            .|..:|..::..   :.||.|...::|..|.||..||.:..|            ..||:  ..:|
Mouse   765 QTVYQLSHDIDAGRYQILMECFTSTFEEVKTLAFDLLMKLSSVTAGQFQDSEKLQDLFQ--AALE 827

  Fly   737 LLLSLRPSDSATGAFQLQVYCKASRVQSEMP------TP---THG----GTIHEPLTFRALQWCL 788
            |..|.:|.|..|.::.|.:..:    |..:|      :|   |.|    ..:.|..|...::..:
Mouse   828 LSTSTKPYDCVTASYLLNLLIR----QDALPAVLSASSPQQLTRGAGETSAVLERNTLVVIKCLM 888

  Fly   789 QHLREGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLKLKELAKEPQWRQYIDELVTMCLAVSSV 853
            ::|.:.:..|:..|.:||...|:||.:.......|:|.|.:|....:||..:..|:.:...:|:|
Mouse   889 ENLEDEISQAENSLLQAASSFPMYGRVHCITRAFQRLPLNDLRLASEWRPLLGRLLLLSYRLSTV 953

  Fly   854 VLPVVSSASPEGHLPETCDQETDQPLTNVLDRQLSRE-----------------ELLQVRT---- 897
            |.||:.|:||||.:|...|..:...|..:|:....|:                 :|..:.|
Mouse   954 VAPVIQSSSPEGLIPVDTDSASASRLQLILNEIQPRDTNDYFNHTKILKECDSFDLEDLSTSVSN 1018

  Fly   898 -----------------TPQMILLCAWRSSKEVCLILGELVQRAPLEEEEDEEQQQQQGDFLLSR 945
                             |.||:|.|.|||.|||.|:||.|.|..|:      :...:..:..|:.
Mouse  1019 IDSSAEVKGKEEKACDVTAQMVLACCWRSMKEVALLLGTLCQLLPV------QPGPESSNVFLTV 1077

  Fly   946 AQLEAIGEHFLQLLAETKHRGAFEQAYVGFTMLCRRFWHSESVRLNQLPGQWVDEAMAMVSGQEE 1010
            .|::.||::|.|.|.:::||||||.||.||..|........:|.|.:||.||:...:..:.|.:
Mouse  1078 QQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEILNRCSNVSLQKLPEQWLRSVLEEIKGSD- 1141

  Fly  1011 WAGKGARLCATRRSAGMPFMLQALVGTELKLGTHATLYRCMNRLLEVCERRTGGAAGITARSHAL 1075
               ..::|||||||||:||.:|||:.:|.|......|...|..|:.:. .....:.|...:.|||
Mouse  1142 ---PSSKLCATRRSAGIPFYIQALLASEPKKSRMDLLKITMRELISLA-LSADDSKGRVPQVHAL 1202

  Fly  1076 NIMRALFRSSELAELVTEFMARGIQCALDGLLLAEEWAERNSATLLLAALIVRVFGVERARLETG 1140
            ||:|||||.:.|.|.:..::|.|.:.|:.| ..:..||.|||:|||.::||.|||||:|.:   .
Mouse  1203 NILRALFRDTRLGENIIPYVAGGAKAAILG-FTSPVWAVRNSSTLLFSSLITRVFGVKRGK---D 1263

  Fly  1141 ELHVRNRMTGRIFFTRYPQLFDYFHAALQRESEQMDAGGGGSENASGKRRQAVQLEAMLLMLSRL 1205
            |:...||||||.||:|:|:|:.:....|:..:..:|:..|..:...|       :..:||:|.||
Mouse  1264 EVSKTNRMTGREFFSRFPELYPFLLKQLETVASTVDSELGEPDRHPG-------MFLLLLVLERL 1321

  Fly  1206 YPSSLEGAESTLNLSEFVPFLIRICHSHDLMTREMAALVVANFVTQEQALAEIRRIVVELKALQL 1270
            |||.::|..|.|:|:.||||:||...|....:|||||..:..|:..:|       |...|.||..
Mouse  1322 YPSPMDGTSSALSLAPFVPFIIRCGRSPIYRSREMAARALVPFIMIDQ-------IPSTLCALLN 1379

  Fly  1271 RLKNTEAANTKLNTNVLHGQLLLLLHLHRLVRWTRPSLTRMQLHTLAELAAPLLQHDACAFSALV 1335
            .|.|  :.:.....|.:||.||.:.||      .:..:|..:..|.|:....|....||..:.|.
Mouse  1380 SLPN--STDQCFRQNHIHGTLLQVFHL------LQAYITDCRHRTNADFLQELSDVTACTKAKLW 1436

  Fly  1336 AVMVAAMEDAVEPGLLDFQLLEQIGVVYLLNH------KEVQSRCQQLGISNRFYQIFGLHLHRL 1394
            ..|      ...|.|:...:  .|.:::||.:      :..|:..:.||......:|. |....:
Mouse  1437 LAM------RQNPCLVTRAV--YIDILFLLTNCLDRPEEGKQTALESLGFWEDVRRII-LESELI 1492

  Fly  1395 RGISQGIVLHIVEDLAETIWALDELKV-ELWLYILLQRSLSEQNSLVSEQDIEHFEFSRDIRRYF 1458
            :|......   |..|.:.:.:|.:|.: |:|      .||:|.....:...:   .|||.::..|
Mouse  1493 KGFPWTFK---VPGLPQYLQSLTKLAIPEVW------ASLAEAKGQATAVPL---SFSRLLKSSF 1545

  Fly  1459 --------ETL-------SREQRE------EVGQELY------ESPAVRSSVLHMMHMIKSS--- 1493
                    :||       .:||:|      .:|:||.      :.|.....||.:::.:..|
Mouse  1546 PEVRLLALDTLLERARSSEQEQKEPLPLLCSMGEELLLLAMKEDHPGCFCRVLKILYHLNPSEWL 1610

  Fly  1494 -KNSC-----------WSLQLAG-----------RLAALQTLLRDPGLELNQLVQRCSEEHSTHQ 1535
             :..|           ||:.:|.           :||:.....|         ||.|.:..
Mouse  1611 PQTECYAHLSPKEFLMWSMDIASNDRSEIQGVALKLASKIIAYR---------VQSCEKNK---- 1662

  Fly  1536 EAGLLLGLRRLIGESKMLERKHWLPMLNYA--QRLVHPGQPVYLRHQAAELCDSLARNHLRDQLV 1598
                         :|...|.:.|:.::.::  ..|     |...|...||:..|.|      .|.
Mouse  1663 -------------DSLAPELRQWVQLVVWSCGDHL-----PTASRLAVAEVLTSTA------PLF 1703

  Fly  1599 AGTTDVDIGLVGRFS--GLVLLLLHDDAEWVRHRAVQLVCGAGLRTRSGAGQE----QEQSAMAP 1657
            ..:....:.|.|..|  ..||.||..:.:.||..|.::|..|..:..:....|    |..:::|.
Mouse  1704 LTSPQPILELQGTLSLWRCVLTLLQSEEQTVREAATEIVTTAMSQGNTCQSTEFAFCQVDASIAL 1768

  Fly  1658 LILPSAL---------IPPFLDTMIGKL--TFDDFNMVQRLVDIIAEPFTTADAMELFDKQENNH 1711
            .:..:.|         :.|.|..::|.|  ..||      |...:..|. ..:...:|:|.|.|.
Mouse  1769 TLALAVLCDLLQQWDQLEPGLPILLGWLLEEGDD------LEGHVQSPH-QGEEEHIFEKSEVNF 1826

  Fly  1712 YCE 1714
            :.|
Mouse  1827 WAE 1829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_608361.3	DUF2428	863..1112	CDD:313558	88/286 (31%)
Thada	NP_898842.2	DUF2428	953..1239	CDD:370999	94/297 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850231
Domainoid	1	1.000	141	1.000	Domainoid score	I4726
eggNOG	1	0.900	-	-		E1_COG5543
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	1	1.000	-	-		oto95220
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	O	PTHR14387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2009
SonicParanoid	1	1.000	-	-		X2730
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730