Protein Alignment Hers and TNRC18

DIOPT Version :9

• Sequence 1: NP_001245771.1
• Gene: Hers / 33000
• FlyBaseID: FBgn0052529
• Length: 2529
• Species: Drosophila melanogaster
• Sequence 2: XP_016868217.1
• Gene: TNRC18 / 84629
• HGNCID: 11962
• Length: 2979
• Species: Homo sapiens
• Alignment Length: 2994
• Identity: 561/2994 - (18%)
• Similarity: 887/2994 - (29%)
• Gaps: 1066/2994 - (35%)

  Fly    12 RVQRSTATAAAAAAAAA----------AAATASSTQGKKRPGKQTKASGGGGDEADDKKSASK-- 64
            |.:...|..||:::..|          :|||..      ||.....::..|..||...:|..|
Human   534 RAEEEAAVVAASSSKKAYLDPGAVLPRSAATCG------RPVADMHSAAHGSGEASAMQSLIKYS 592

  Fly    65 ----TDSAAKKPA----KDPTG------------SSGVSTATT----EGGAGNGGGKQTTSTTTS 105
                .|:.|.:|.    |.|.|            |:|.|.|..    .||...|||:|.......
Human   593 GSFARDAVAVRPGGCGKKSPFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQLKRDPER 657

  Fly   106 STSSTTAPSASASASASNSLKLSP--------EERHEDGKARA------INKMLKSLDIKIHG-- 154
            ..|:.......:.|.....::..|        .::...|..|.      ..:.|...::|.||
Human   658 PESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLGPGLVDQERSLSLSNVKGHGRA 722

  Fly   155 ----FDNLLPSGEERLNDGVLKSSISENVKTKSRAAAVKVI-------SSLNPGKM--------- 199
                .|:.....||||....|.....:.::.....|.:..:       :.|||..|
Human   723 DEDCVDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAPNGLNPNLMVTGGPALAG 787

  Fly   200 ------------------------------------PPVKRVRPSP------------------E 210
                                                ||......:|                  :
Human   788 SGRWSADPAAHLATHPWLPRSGNASMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRD 852

  Fly   211 PVREKVAEKPAEKVLDKEKPKAEQQITPPPAPEESPASKVPKKTVQQAKKAKVESSLVQATVLTT 275
            |...::...|::. |.......|:...||..|...|..:.|....||.:....:..|.|...|..
Human   853 PQSGQLVVIPSDH-LPHFAELMERATVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQEFLYL 916

  Fly   276 TSAATSAPSSASTSKHTSTKNPGKKSAHSEQMPKKELSK-LAKMGK-----------PKKEANLV 328
            ...|..|.....:::....:.  |...|..:|.:|...: |...||           |:|...|.
Human   917 QQQAAQALELQRSAQLVQERL--KAQEHRAEMEEKGSKRGLEAAGKAGLATAGPGLLPRKPPGLA 979

  Fly   329 KSTARLPDSNTESVQMELEEIVSTPTVTPTPSATPTATPTPTATPTLTPTPTATRTRTPTPTLTP 393
            ...|.           ...:.||.|   |:|.|:|.|.........|...........|.   ||
Human   980 AGPAG-----------TYGKAVSPP---PSPRASPVAALKAKVIQKLEDVSKPPAYAYPA---TP 1027

  Fly   394 TPTPTSTPSSTAIAAGQPAPPPPPPGGAPKQRPKVKYTKTSAGSKGRMQQALNQKAPA---ASWS 455
            :..|||.|         ||.|||.||...|:.......:       :....|.::||:   |.:|
Human  1028 SSHPTSPP---------PASPPPTPGITRKEEAPENVVE-------KKDLELEKEAPSPFQALFS 1076

  Fly   456 GAKDIYDFKS----------------------GSEDEEPIKMVLPSLKELREFSDEDNKPLKLFE 498
            .....|.|::                      |...:.|:....|   |....|.|| ||::|
Human  1077 DIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGP---ERLALSPED-KPIRL-- 1135

  Fly   499 RQAEKTKVQVQDEEEQPLVK-KEEKPPSEKEVKVKSKEKEKEKEKDVDPLSNAQQSEPAAKHTTS 562
               ..:|:      .:||.: .||:|.:|:|||.:.::.: |...::.||.:.... |||:
Human  1136 ---SPSKI------TEPLREGPEEEPLAEREVKAEVEDMD-EGPTELPPLESPLPL-PAAE---- 1185

  Fly   563 TSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKGKAAAAKEPPPSGSSAESSSSEDERKLS 627
                              .:|||.|:..      .|.|...|........|.||.|...|
Human  1186 ------------------AMATPSPAGG------CGGGLLEAQALSATGQSCAEPSECPD----- 1221

  Fly   628 AYSGPKRHRMASLNALAKVQCLYENESRT-----AHELG-------LSKATQQPPRIRTLDGSDD 680
            ...||:..              .::..||     |.:||       |.:|.::|..:
Human  1222 FVEGPEPR--------------VDSPGRTEPCTAALDLGVQLTPETLVEAKEEPVEV-------- 1264

  Fly   681 DNHKDSPRHGDTDRDKGSVSPPHTSAAPP--AAPIAPPKEAEPRRELR--YVPGGRGVGKHWE-- 739
                             .|:.|...|.|.  .|.:| |.|::|..|:.  .||.|.|.....|
Human  1265 -----------------PVAVPVVEAVPEEGLAQVA-PSESQPTLEMSDCDVPAGEGQCPSLEPQ 1311

  Fly   740 -----FDSDSETEELQLQQTLPPVK-----------KKKLPKKAP---PKKVASSETDAKRKKKS 785
                 ..|....||....|.||.::           ..:||:..|   |....:...:.....:|
Human  1312 EAVPVLGSTCFLEEASSDQFLPSLEDPLAGMNALAAAAELPQARPLPSPGAAGAQALEKLEAAES 1376

  Fly   786 VQVEESD------DEEAKEKEKEKEKPKPPKQLPKKRKTAFTEELIGDYKGILARKRMASLNASA 844
            :.:|:|.      ..|..|.|.|:.                ::|:.|..:.::||..:.||
Human  1377 LVLEQSFLHGITLLSEIAELELERR----------------SQEMGGAERALVARPSLESL---- 1421

  Fly   845 IVAATYEVERHLD-------KNLA----------------------SDCSSFESYD--ELDTMPT 878
            :.|.::.:...||       |||.                      :..||.|..|  |||
Human  1422 LAAGSHMLREVLDGPVVDPLKNLRLPRELKPNKKYSWMRKKEERMYAMKSSLEDMDALELD---- 1482

  Fly   879 TTSKVTSAAAIKTEVIHIKKEPKESKESLRERERERESERRRE---------------------- 921
                      .:..:..::::.||.:..|.:.:|.|:||.|||
Human  1483 ----------FRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHAPS 1537

  Fly   922 -----RDNELKDSTVGKMSSHSIIEESND-------SKYSKETKETNTDTTITTTGYRDSAASTK 974
                 |.......:.||:||.|:: .|:|       .|..|.::|.:  ..:...|.......|.
Human  1538 ALSPPRKRGKSGHSSGKLSSKSLL-TSDDYELGAGIRKRHKGSEEEH--DALIGMGKARGRNQTW 1599

  Fly   975 DAKDCSRPTSSSVVIVQDTDVTITGVYVNASNGAAQEAYCKMQYRVQSSVTEERVLRPGSVEPPK 1039
            |..:.|            :|. |:.:.:.....|:.:.....:.....|:|::..|:     .|.
Human  1600 DEHEAS------------SDF-ISQLKIKKKKMASDQEQLASKLDKALSLTKQDKLK-----SPF 1646

  Fly  1040 SYTPLSALSSMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHAL 1104
            .::..:...|....|....|:                |:..|.|::..|   .|..|||..:.:.
Human  1647 KFSDSAGGKSKTSGGCGRYLT----------------PYDSLLGKNRKA---LAKGLGLSLKSSR 1692

  Fly  1105 PDHHGPPPPSYAAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHAAHAHHYQQAAEYHGGP 1169
            ...|       ..||........:.|.
Human  1693 EGKH-------KRAAKTRKMEVGFKAR-------------------------------------- 1712

  Fly  1170 PPPPHHYGGPPPQGHYGPPPGAPVPVPVAVPNTVTVPPERCDVGSPPPSYRASAYPPPSSVGMPP 1234
                    |.|...|                     .|...:|.|  .||...:......:....
Human  1713 --------GQPKSAH---------------------SPFASEVSS--YSYNTDSEEDEEFLKDEW 1746

  Fly  1235 PTLGGGSSAFCAPSPLHHHQHQHQQPGPGVGPPHHDPSGYYQPAGPLISPHVIAAP----PPPAQ 1295
            |..|..||.. .||.|.....::.:..                .||.::...:|||    |.||.
Human  1747 PAQGPSSSKL-TPSLLCSMVAKNSKAA----------------GGPKLTKRGLAAPRTLKPKPAT 1794

  Fly  1296 VKK------LQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQSQSQGQSHGH---AHSH 1351
            .:|      |:|.:...|.:.|..:...|..::|     .:....:.:.:.:....|:   |...
Human  1795 SRKQPFCLLLREAEARSSFSDSSEESFDQDESSE-----EEDEEEELEEEDEASGGGYRLGARER 1854

  Fly  1352 AHNPQ------------QAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYS----- 1399
            |.:|.            .|...|.|...|:.:|....|...|.: ....:|:...:..|:
Human  1855 ALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARK-KEERQSLLGTEFEYTDSESE 1918

  Fly  1400 -----------------TGYP-PNYYAPYPGEVMCYSPPTYPPYFSSKVYQPSHP---------A 1437
                             .|.| |:..||.||               ::...||.|         .
Human  1919 VKVRKRSPAGLLRPKKGLGEPGPSLAAPTPG---------------ARGPDPSSPDKAKLAVEKG 1968

  Fly  1438 HPAAHPQGPPPPGAYRRYPYYQHAGPPPPHE------------LYE-QQPPPPPVSSGSVSGPAQ 1489
            ..|...:||..||.        .|||....:            |:: ....|.|||    :.||.
Human  1969 RKARKLRGPKEPGF--------EAGPEASDDDLWTRRRSERIFLHDASAAAPAPVS----TAPAT 2021

  Fly  1490 QQPPTSSPASVGAAG----AGTAGAPSGSQLVPA--HQQQHQQQHLEHYPGPPSYYAGYSPGGGA 1548
            :   ||..|..|...    ||.|......:.|||  .:.:|.::            .|...|.||
Human  2022 K---TSRCAKGGPLSPRKDAGRAKDRKDPRKVPATVSKGRHWKK------------KGKEAGPGA 2071

  Fly  1549 SAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIISNIDQSSSCSSSMLLSATSNS 1613
                    ||.      ||:.|. :|...     ..||..|
Human  2072 --------GLP------PPRAPA-LPSEA-----RAPHASS------------------------ 2092

  Fly  1614 NIGGGSSSSSSSSSSTTLPACSSATTTTTASALTTSRGPVKNVTPNNSNSSGHTS--TNSCRSSN 1676
                                       .||:..:.::...|.|...|....|..|  ..|..:..
Human  2093 ---------------------------LTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESMAAEE 2130

  Fly  1677 NSNNSSNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGE----NPQVTKMQYEA 1737
            :...:.:||....|......|...       ..|...:..::.|.|||..    .|...|:.|..
Human  2131 DFEPNQDSSFSEDEHLPRGGAVER-------PLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAG 2188

  Fly  1738 HVMPPPTP--------------PESYCASDEKLLDDQEQEAELELR------LRLGLGLEKSHGG 1782
            ||....:|              |..||.  |:||    |||.:::|      |..|..: .::..
Human  2189 HVQTVHSPDIYRVVVEGERGNRPHIYCL--EQLL----QEAIIDVRPASTRFLPQGTRI-AAYWS 2246

  Fly  1783 QQ--------------------------------------HIEA----YDLTCSTP-PPVTVPQA 1804
            ||                                      ||..    |.:.|:.| |.:.||.|
Human  2247 QQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSA 2311

  Fly  1805 AAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAKLEAEPEMPFVLKAEIKAETKIKIEH 1869
            ....||........::...|..:            |..||.......|   .|:.|.:
Human  2312 KRRSRKTSKDTGEGKDGGTAGSE------------EPGAKARGRGRKP---SAKAKGD------- 2354

  Fly  1870 DGEAQASTHISQLPDLKPTIKTEPEQELEQEAASVPSVAKTEPQP---EVEVEREQQEPPVDEEQ 1931
                :|:|    |.:..||.:. |...|..|.:|.|...|:.|:|   ..:..:.:..||
Human  2355 ----RAAT----LEEGNPTDEV-PSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPP----- 2405

  Fly  1932 QPTPGGSKQRFNLLALSSGNKKTKTNNSYKSLIKQAEPKSYLCPG-RRFIRRHGRAPAKYVKRRQ 1995
            ||:|                               |.|....||. ..|...  .|||..:....
Human  2406 QPSP-------------------------------APPAFTSCPAPEPFAEL--PAPATSLAPAP 2437

  Fly  1996 MILTQRQQQRMRLQRREQQQQRRQQREAAAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQ----A 2056
            :|.....:.:.:..|..::...:..|                  .|.|:|  |:.:..|.    :
Human  2438 LITMPATRPKPKKARAAEESGAKGPR------------------RPGEEA--ELLVKLDHEGVTS 2482

  Fly  2057 PNSSATPSASPKRARPRK---QEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAP---TAVGGL 2115
            |.|.....|...|..|..   ||..:|         ||.|  |.|....||..:||   ...|.|
Human  2483 PKSKKAKEALLLREDPGAGGWQEPKSL---------LSLG--SYPPAAGSSEPKAPWPKATDGDL 2536

  Fly  2116 YAASSPLTTATDH---------RGKQTTAEK-RSKSETKKPPSGESSESGLPCKKPRKEPAGKVK 2170
            .....|..|..|.         :.:|..||: .|.|.:....|..||.|.....:...|..|...
Human  2537 AQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKN 2601

  Fly  2171 GKGKKTTAG----AAATTIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAK 2231
            |.|...|.|    ||::..||.|.:.:.:.::.::|:..::::...::...:.......:.:.:.
Human  2602 GDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2666

  Fly  2232 VAGTATSTSTAS------QQQNQQHSDEQHQFLVPSQPATASATAALAA---------------- 2274
            .:.:::|:|::|      .:.:...||::   ..|:..|..||.|||..
Human  2667 SSSSSSSSSSSSSSSSTTDEDSSCSSDDE---AAPAPTAGPSAQAALPTKATKQAGKARPSAHSP 2728

  Fly  2275 ---TPPPSRQGQATH-TKRTRSRCKFGNRKRQRHRPGGVSYELDVTQPPATKANVVPKWNNG--- 2332
               ||.|..|..... |:..:.:.:.|.:.|.:.|.|   ..|..|:..| |...:|...|.
Human  2729 GKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRPKKREG---VHLPTTKELA-KRQRLPSVENRPKI 2789

  Fly  2333 ---------WMWAGKAFQGAVFLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLLKANEDNELP 2386
                     |.|.||..|..........|.    |.|:  |.| ::|||.|| |.|.|...| ||
Human  2790 AAFLPARQLWKWFGKPTQRRGMKGKARKLF----YKAI--VRGKEMIRIGDCAVFLSAGRPN-LP 2847

  Fly  2387 YVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGR------------------------QRNDCPD 2427
            |:.::..:|:: ....|::.:.|:|.||.|..|:                        ||.|..:
Human  2848 YIGRIQSMWES-WGNNMVVRVKWFYHPEETSPGKQFHQGQHWDQKSSRSLPAALRVSSQRKDFME 2911

  Fly  2428 E-VYASRHRDHNSVACVEDKCYVLTFSEYCRYRRRLRAAE-EDVEDV-----SIVPRRPSIATAP 2485
            . :|.|.|.|.|.|..|..||.|:...:   |.:.|:..: :|.|.:     :..|....|.:..
Human  2912 RALYQSSHVDENDVQTVSHKCLVVGLEQ---YEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTD 2973

  Fly  2486 GFPV 2489
            |.||
Human  2974 GVPV 2977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	43/157 (27%)
TNRC18	XP_016868217.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810