DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hers and BAHCC1

DIOPT Version :9

Sequence 1:	NP_001245771.1	Gene:	Hers / 33000	FlyBaseID:	FBgn0052529	Length:	2529	Species:	Drosophila melanogaster
Sequence 2:	NP_001278253.1	Gene:	BAHCC1 / 57597	HGNCID:	29279	Length:	2639	Species:	Homo sapiens

Alignment Length:	3012	Identity:	564/3012 - (18%)
Similarity:	870/3012 - (28%)	Gaps:	1100/3012 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 KSRAAAVKVISSLNPGKMPPVK----RVRPSPEPVREKVAEKPAEKVLDKEKPKAEQQITPPPAP 242
            :|.|||.: ::...|...||..    :..|||.|:....|   :.:::.
Human    22 RSAAAAAR-LAPAGPAAQPPAHFQPGKYFPSPLPMASHTA---SSRLMG---------------- 66

  Fly   243 EESPASKVPKKTVQQAKKAKVESSLVQATVLTTTSAATSAPSSASTSKHTSTKNPGKKSAHSEQM 307
             .||||..        ..:.:.|||..|.....:..::|.|..|....|.:|....  .:||.:.
Human    67 -SSPASSF--------MGSFLTSSLGSAASTHPSGPSSSPPEQAYRGSHPTTSQIW--FSHSHEA 120

  Fly   308 PKKELSKLAKMGKPKKEANLVKSTARLPDSNTE---------------SVQMELEEIVSTPTVTP 357
            |          |.|:...:|  ::..||.|:.:               ..|.:...:.:.|
Human   121 P----------GYPRFSGSL--ASTFLPVSHLDHHGNSNVLYGQHRFYGTQKDNFYLRNLP---- 169

  Fly   358 TPSATPTATPTPTATPTLTPTPTATRTRTPTPTLTPTPTPTSTPSSTAIAAGQPAPPPPPPGGAP 422
                     |.||..|.....|:..|                            |.|..|.|...
Human   170 ---------PQPTLLPANHNFPSVAR----------------------------AAPAHPMGSCS 197

  Fly   423 KQRPKVKYTKTSAGSKGRMQQALNQKAPAASWSGAKDIYDFKSGSEDEEPIKMVLPSLKELREFS 487
            :.|.:        |..|.:|:            |.||...|..|.|
Human   198 RDRDR--------GEAGSLQK------------GPKDFDRFLVGKE------------------- 223

  Fly   488 DEDNKPLKLFERQAEKTKVQVQDEEEQPLVKKEEKPPSEKEVKVKSKEKEKEKEKDVDPL---SN 549
                    |...:|.|.            .:.:|:|.:|       ::..||:.|.|.|:   .:
Human   224 --------LGREKAGKA------------AEGKERPAAE-------EDGGKERHKLVLPVPADGH 261

  Fly   550 AQQSEPA--------AKHTTSTSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKGKAAAAK 606
            .::..||        .||.||....:......:.:.|....|..|....|....|.|:    .||
Human   262 CREGGPAPRGACEGRPKHLTSCLLNTKVLNGEMGRAALASCAGGMLGRPGTGVVTSGR----CAK 322

  Fly   607 EP--PPSGSSAESSSSEDERKL---SAYSGPKRHRMASLNALAKVQC------LYENESRTAHEL 660
            |.  ||....|.|...|..:.|   ::|:||......:..:...:|.      |...:.:...:|
Human   323 EAAGPPEPGPAFSECLERRQMLHHTASYAGPPPPLSTAAGSFPCLQLHGGPDGLCPLQDKAPRDL 387

  Fly   661 GLSKATQQPPRIRTLD--------------GSDDDNHKDSPRHGDTDRDKGSVSPPHTSAAPPAA 711
            ..|..|..|......|              |...|.|.:           |:::|.|  |||...
Human   388 KASGPTFVPSVGHLADKGRPFQAAEACAVAGEGKDRHLE-----------GTMAPDH--AAPYGV 439

  Fly   712 PIAPPKEAEPRRELRYVPGGRGVGKHWEFDSDSETEELQ-LQQTLPPVKKKKLPKKAPPK----K 771
            ..|..| ||.:.|.|  |||      :|...:...:.|. |....|......|||....|    :
Human   440 SYAHLK-AEGKGERR--PGG------FEAALNPRLKGLDYLSSAGPEASFPGLPKSGLDKSGYFE 495

  Fly   772 VASSETDAKRKKKSVQVEESDDEEAK--------EKEKEKEKPKPPKQLPKKRKTAFTEELIG-- 826
            :.:|..|..|.      ...|....|        :|...||.|..|....|..:....:.|:.
Human   496 LPTSSQDCARP------GHQDPLGGKAPQACCTLDKTVGKEAPAGPPGAQKVARIRHQQHLMAAE 554

  Fly   827 -DYKGILARKRMASLNASAI-----------------VAATYEVERHLDKNLASDCSSFESY--- 870
             :..||.|..:..||..:::                 .|.....||.....|....|..:..
Human   555 VEQGGIGAEAKRKSLELASLGYSGPHLPPWGVQAGQGTAMAISEERKAGAYLDPFGSGLQQAALL 619

  Fly   871 -DELDTMPTTTS------KVTSAAAI---KTEVIHI----------------KKEPKESKESLRE 909
             .||...|...|      |.:|.|.:   |..::.:                .|.|.:|:.....
Human   620 PQELPAPPDEVSAMKNLLKYSSQALVVGQKAPLVGLGGLKASCIQQEAKFLSSKGPGQSERPDCA 684

  Fly   910 RERERESERRRERDNELKDSTVGKMSSHSIIEESNDSKYSKETKETNTDTTITTT-------GYR 967
            |.||.::   ...|.|::...||  .:.::..:.:....|:....|||.......       |.|
Human   685 RSREHDT---THGDGEVRQPPVG--IAVALARQKDTVSRSEAAYGTNTARQGRAAPAFKGGGGPR 744

  Fly   968 DSAASTKDAK-------DCSRPTSSSVVIVQDTDVTITGVYVNASNGAAQEAYCKMQYRVQSSVT 1025
            .:.|...:|:       |.....:|..:::||:...:....::..:..
Human   745 STHALDLEAEEERTRLCDDRLGLASRELLLQDSKDRVEFARIHPPSSC----------------- 792

  Fly  1026 EERVLRPGSVEP------------------------PKSYTPL------------SALSSMLPPG 1054
                  ||.:.|                        |::.:|.            .||...||||
Human   793 ------PGDLAPHLMMQSGQLGGDPAPHTHPHPPWLPRTRSPSLWMGGHSYGLGHPALHQNLPPG 851

  Fly  1055 -ASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHALPDHHGPP---PPSY 1115
             .:|......|..||| ..||| ..|:||.|...   :.||       |||.|.....   ||.|
Human   852 FPASVAGPVPSVFPLP-QDAPT-QLVILPSEPTP---HSAP-------HALADVMDQASLWPPMY 904

  Fly  1116 AAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHA---------AHAHHYQQAAEYHGGP-- 1169
            .                   |.|...||.|..|...::         .:|...|:||::...|
Human   905 G-------------------GRGPASHMQHPGQLPVYSRPQLLRQQELYALQQQRAAQFQRKPED 950

  Fly  1170 ---------------------------PPPPHHYGGP---PPQGH---YGPPPGAPVPVP-VAVP 1200
                                       |..|....||   ||..|   ..||..:|.|.| .:.|
Human   951 QHLDLEEPAQEKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHPPDPKPPASSPTPPPRPSAP 1015

  Fly  1201 NTVTVPPERCDVGSPPPSYR--------------------------------------ASAYPPP 1227
            .|:.|    |...||.|..|                                      ||..|..
Human  1016 CTLNV----CPASSPGPGSRVRSAEEKNGEGQQSTADIITSEPVARAHSVAHAGLEFLASNDPST 1076

  Fly  1228 SS------VGMPP----PTLGGGSSAFCAPSPLHHHQHQH----QQPGPGVGPPHHDPSGYYQPA 1278
            |:      ..:||    |..|.|   |..||.:|....:.    |...||..|   :|:..:.|.
Human  1077 SASQSFGITDLPPGYLRPMAGLG---FSLPSDVHSSNLEDPETMQTTAPGAQP---EPTRTFLPG 1135

  Fly  1279 GP-------LISPHVI-----------AAPPP-----------PAQVKKLQE------------- 1301
            .|       |..|.::           |.|.|           |:.::.|||
Human  1136 EPPPCSPRSLEEPGLLSGAREATQDLAATPYPTERGPQGKAADPSPLEGLQELQCAALLEAGGPE 1200

  Fly  1302 ---------------------EDGPVSA---------AGSPTQLQQ--QQAAAEAAAAAADQAAA 1334
                                 |.||.|.         ||||..|:.  :|.|.|......|:...
Human  1201 ATGQAHSTQGGAREERSREEGEQGPSSGASSQVLEQRAGSPGALEDEGEQPAPEEDELEEDELGQ 1265

  Fly  1335 QSQSQSQGQSHGHAHSHAHNPQ------------------QAQHPPQPQPYPAGAVAAAAAAAAA 1381
            ||...|: :..|.|..::|.|:                  .:..||.|||       .||:...:
Human  1266 QSMEDSE-EDCGGAPDNSHPPRALPGLDALVAATINLGDLPSDSPPDPQP-------PAASGPPS 1322

  Fly  1382 HQGVPYSRSMH------------------------------------------------AAQMHY 1398
            ...:|:|..:|                                                ||.:..
Human  1323 TVPLPHSSGIHGIALLSELADLAIQRQRSERTVPEEEEDVLAFNLQHLATLATAWSLVEAAGLDS 1387

  Fly  1399 ST--GYPPNYYAPYPGEVM-----------CYSPPTYP--PY----------------------- 1425
            ||  ..||. ..|..|..:           .::|.|.|  |.
Human  1388 STAPAQPPT-ANPCSGPRLTPRMQILQRKDTWTPKTKPVCPLKAAIDRLDTQEVGMRVRLAELQR 1451

  Fly  1426 -FSSKVYQ-----------------------PSHP-------AHPAAHPQGPPP----------- 1448
             :..|..:                       |..|       :.||..|.||.|
Human  1452 RYKEKQRELARLQRKHDHERDESSRSPARRGPGRPRKRKHSSSLPAPRPTGPLPRSDGKKVKAVR 1516

  Fly  1449 -----------------PGAYRR------YPYYQHA----------------GPPPPHELYEQQP 1474
                             |...|.      |...|.|                .|...|.:  .|.
Human  1517 TSLGLLCAELRGGSGGEPAKKRSKLERSVYAGLQTASVEKAQCKKSSCQGGLAPSVAHRV--AQL 1579

  Fly  1475 PPPPVSSGSVSGPAQQQPPTSSPA-----------SVGAAGAGTAGAPSGSQLVPAHQQQHQQQH 1528
            .|...|.|..:|.:..|...::|.           |...:||.....|.|          |..:.
Human  1580 KPKVKSKGLPTGLSSFQQKEATPGGRIREKLSRAKSAKVSGATRHPQPKG----------HGSRE 1634

  Fly  1529 LEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIIS 1593
            ....|..||..|....|.|..:..|  .||.|  .|.|       |:.....:|||..:..
Human  1635 TPRCPAQPSVAASQEAGSGYDSEDC--EGLLG--TEAP-------PREAGLLLHTGASVAV---- 1684

  Fly  1594 NIDQSSSCSSSMLLSATSNSN--------IGGGSSSSSSSSSSTTLPACSSATTTTT-------- 1642
               ...|.||.:.:.|...:.        :|....||..|.......:..:...||.
Human  1685 ---LGPSPSSVVKMEANQKAKKKKERQGLLGACRLSSPESEVKIKRRSVKAKVGTTLERAPGQRP 1746

  Fly  1643 --ASALTTSRGPVK-------NVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAA 1698
              |.....::|..|       ..||:.......:...:||...:...|......|.:.|......
Human  1747 PGALGKKKAKGKAKGSLRAEPGATPSRDALFNPSRAFACREEGSQLASERLKRATRKGTVLQPVL 1811

  Fly  1699 TNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEA----------HVMPPPTPPESYCASD 1753
            .......:.|..|.....:|      |:..:::|::::|          .::      ||:...:
Human  1812 RRKNGALSITLATRNAKAIL------GKGRKLSKVKHKAGKQGKGRAVSRLL------ESFAVEE 1864

  Fly  1754 EKLLDD-----QEQEAELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARI 1813
            :...||     :|:|.|.|         |:...|               |::..|:||:.|...|
Human  1865 DFEFDDNSSFSEEEEDEEE---------EEEDSG---------------PLSAEQSAALARSCAI 1905

  Fly  1814 GKSMARE-----------MVYAA---------------------QQQLLPEKQLKQPKEAAAKLE 1846
            .|...|:           ::||.                     :|::...:||.|    .|.|:
Human  1906 HKEDLRDGLPVLIPKEDSLLYAGSVRTLQPPDIYSIVIEGERGNRQRIYSLEQLLQ----EAVLD 1966

  Fly  1847 AEPEMPFVLKA---------------------------EIKAETKIKIEHDGEAQASTHISQLPD 1884
            ..|:....|..                           |.:....:.:|.|........:|.:..
Human  1967 VRPQSSRYLPPGTRVCAYWSQKSRCLYPGNVVRGASGDEDEDLDSVVVEFDDGDTGHIAVSNVRL 2031

  Fly  1885 LKPTIK---TEPEQEL--EQEAASVPSVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNL 1944
            |.|..|   |||...|  .........|:...|.|.     |...|.:..:.|..|...|
Human  2032 LPPDFKIQCTEPSPALLVSSSCRRTKKVSSEAPPPS-----EAATPSLSPKAQDGPEALK----- 2086

  Fly  1945 LALSSGNKKTKTNNSYKSLIKQAEPKSYLCPGRRFIRRHGR-----APAKYVKRRQMILTQRQQQ 2004
               :.|.|....:.:.|:.:..:..||.......|:.|.|.     :.....||:.:....:...
Human  2087 ---TPGKKSISKDKAGKAELLTSGAKSPTGASDHFLGRRGSPLLSWSAVAQTKRKAVAAASKGPG 2148

  Fly  2005 RMR-LQRREQQQQRRQQREAAAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNSSAT----PS 2064
            .:: |.:.....::.:.|||...|  .:|.|| :.||.. :|.|..|:....||....|    |.
Human  2149 VLQNLFQLNGSSKKLRAREALFPV--HSVATP-IFGNGF-RADSFSSLASSYAPFVGGTGPGLPR 2209

  Fly  2065 ASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDHR 2129
            .:.|..|.:|.|                            |.:|..  ||...|........||.
Human  2210 GAHKLLRAKKAE----------------------------RVEAEK--GGRRRAGGEFLVKLDHE 2244

  Fly  2130 GKQTTAEKRSKSETKKPPSGE---SSESGLPCKKPR-KEPAGKVKGKGKKTTA-------GAAAT 2183
            |..:...|..|:..    .|:   |.:.|.|...|. ..||  :.||.||..|       |.|..
Human  2245 GVTSPKNKTCKALL----MGDKDFSPKLGRPLPSPSYVHPA--LVGKDKKGRAPIPPLPMGLALR 2303

  Fly  2184 TIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTAS----- 2243
            ..|..||......:...:|..:.:.:....|.....:|....:|:.:. :|::||:|:.|
Human  2304 KYAGQAEFPLPYDSDCHSSFSDEDEDGPGLAAGVPSRFLARLSVSSSS-SGSSTSSSSGSVSTSS 2367

  Fly  2244 -----QQQNQQHSDEQHQFLVPSQPATASATAALAATPPPSR-QGQATHTKRTR---SRCKF--- 2296
                 .:.:...||::...|: .|.........|.|.|...| :|...|....|   ||...
Human  2368 LCSSDNEDSSYSSDDEDPALL-LQTCLTHPVPTLLAQPEALRSKGSGPHAHAQRCFLSRATVAGT 2431

  Fly  2297 -------GNRKRQRHRPGGVSY----ELDVTQPPATKANVVPKWN------NGWMWAGKAFQGAV 2344
                   .:.|.:..|...:|:    ||...|.|.:..| .||.:      ..|.|:|...|...
Human  2432 GAGSGPSSSSKSKLKRKEALSFSKAKELSRRQRPPSVEN-RPKISAFLPARQLWKWSGNPTQRRG 2495

  Fly  2345 FLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLLKANEDNELPYVAKVAHLWQNPEDGEMMMSL 2407
            .......|.    |.|:  |.| :.:|:.|| |.|.|...| |||:.::..:|:: ....|::.:
Human  2496 MKGKARKLF----YKAI--VRGEETLRVGDCAVFLSAGRPN-LPYIGRIESMWES-WGSNMVVKV 2552

  Fly  2408 LWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDVEDV 2472
            .|:|.||.|..|:::.|..:.:|.|.|.|.|.|..:..||.|:...:|.:..|..:.  :|.:|:
Human  2553 KWFYHPEETKLGKRQCDGKNALYQSCHEDENDVQTISHKCQVVAREQYEQMARSRKC--QDRQDL 2615

  Fly  2473 SIV-----PRRPSIATAPGFPV 2489
            ..:     |....:.||.|.|:
Human  2616 YYLAGTYDPTTGRLVTADGVPI 2637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	38/131 (29%)
BAHCC1	NP_001278253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..49		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..107		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..249		20/126 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	669..702		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..746		6/29 (21%)
		Atrophin-1	<850..1253	CDD:331285	93/443 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..1047		24/111 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1104..1331		47/237 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1457..1513		8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1582..1666		21/97 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1722..1776		7/53 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1893		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2119		13/74 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2317..2336		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2348..2383		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2432..2472		8/40 (20%)
		BAH_BAHCC1	2512..2631	CDD:240065	33/122 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810