Protein Alignment Hers and wge

DIOPT Version :10

• Sequence 1: NP_608360.2
• Gene: Hers / 33000
• FlyBaseID: FBgn0052529
• Length: 2529
• Species: Drosophila melanogaster
• Sequence 2: NP_732790.3
• Gene: wge / 42687
• FlyBaseID: FBgn0051151
• Length: 1669
• Species: Drosophila melanogaster
• Alignment Length: 1926
• Identity: 366/1926 - (19%)
• Similarity: 589/1926 - (30%)
• Gaps: 634/1926 - (32%)

  Fly   838 ASLNASAIVAATYEVERHLDKNLAS-----------DCSSFESYDELDTMP-------TTTSKVT 884
            ||.:|:.:::||......|....|:           ....|..:......|       .|.|..|
  Fly     8 ASSSAADVLSATTATATFLVPTTAAVSHPGAHTAHLQLDQFGGFSAATATPLQHHHHQQTNSSYT 72

  Fly   885 SAAAIKTEVIHIKKEPKESKESLRERERERESERRRERDNELKDSTVGKMSSHSIIEESNDSKYS 949
                    .:.||:||.:..|.......:::.:..:...::::..   .:||.|:...|
  Fly    73 --------FVQIKREPCQVSEISSNNCHQQQQQHHQHHQHQVQHQ---GLSSASMTASS------ 120

  Fly   950 KETKETNTDTTITTTGYRDSAASTKDAKDCSRPTSSSVVI------------------------V 990
                :|.:.:|:||. .:..|.|.| ..:..:.|.:||.|                        :
  Fly   121 ----KTMSSSTLTTL-VKIEAPSPK-VSELEKSTGNSVPIGIAVARKRPQEALVPAINTPATLPL 179

  Fly   991 Q---DTDVTITGVYVNASNGAAQEAYCKMQY--------RVQSSVTEERVLRPGSV-EPPKSY-- 1041
            |   :.|:...|:.| |..||..   |...|        ...::..||..|....| ..|.::
  Fly   180 QPPLNKDLNCFGIRV-ADLGATS---CGNLYFTGNGDLMTTGTATAEELALSAAGVNRAPSTFWQ 240

  Fly  1042 ----TPLSALSSMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEH 1102
                .|:.::.||.|  |:.||..:..        |..|..||||....:.|:.:.|.|
  Fly   241 YPNALPIESVISMSP--ATVGLQYSRE--------ASRGQVVLLPAGPTALGISNFPLL------ 289

  Fly  1103 ALPDHHGPPPP-SYAAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHAAHAHHYQQAAEYH 1166
                  .|..| ..||||||....:||.....||||         |..||.||.|
  Fly   290 ------TPTDPFQQAAAAAAFVWPSAYIPQAPAPGG---------HSAAAAAAAA---------- 329

  Fly  1167 GGPPPPPH-----HYGGPPPQGHYG----PPPGAPVPVPVAVPNTVTVPPERCD----------- 1211
             ...|.|:     ::..|...||..    |...:.:.:.:|...|.|.....|.
  Fly   330 -SLQPTPNLSSLPNFIFPSMGGHQALSTTPSYASTLQLYLAAAATATGSSTMCQHSNQQTSTTTT 393

  Fly  1212 ---------VGS-----------------------------------------PPPSYRASAYPP 1226
                     .||                                         |||:.....||.
  Fly   394 NSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSSRFLSLATGQTGIPSLLSLPPPTGLKEEYPM 458

  Fly  1227 PSSVGMPP-------------------PTLGGGSSAFCAPSPLHHHQHQHQQPGPGVGPPHHDPS 1272
            |  :.:||                   ||  ..:||...||.|.|            ..|||
  Fly   459 P--LALPPLVPLEAARDKEQALNLMRLPT--PPTSATMEPSSLGH------------ATPHH--- 504

  Fly  1273 GYYQPAGPLISPHVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQ 1337
             .:| :|.:       |.|.||.:.        :|..|:..:|    .||....|.:|:||...:
  Fly   505 -LFQ-SGAM-------ATPTPALLN--------LSMHGNGGEL----PAATPLPAVSDEAALNYK 548

  Fly  1338 SQSQGQSHGHAHSHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGY 1402
                          .|.|...|.||:....|         .:.:.|.:|..:     .::..|..
  Fly   549 --------------LHAPLTPQTPPRLADIP---------VSGSTQLLPQMQ-----DVNIQTDT 585

  Fly  1403 P--------PNYYAPYPGEVMCYSPPTY-PPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYY 1458
            |        |....|.......:.|||: .|...:|..:.||......|.|..|..
  Fly   586 PVCSEDESFPGSAKPQDPAAEAFPPPTHVQPLELTKPSEASHTQPTECHTQTEPSD--------- 641

  Fly  1459 QHAGPPPPHELYEQQPPPPPVSSGSVSGPAQQQPPTSSPASVGAAGAGTAGAPSGSQLVPAHQQQ 1523
               .|....|...:|.||.|:.:.:.:..|.|..|.........:...|...|    ||  ..:|
  Fly   642 ---IPSASQEESAEQTPPEPIETMTQATQADQTSPEDLTGLELLSNISTNSKP----LV--RVKQ 697

  Fly  1524 HQQQHLEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCP----------------CP 1572
            ...:|:|. |.|........|              ..|.:..||...                |.
  Fly   698 EPVEHIEQ-PAPQPQPVNIMP--------------SEPTLPMPPMLEMEPTSEREPLGGLKLLCA 747

  Fly  1573 MPQSCPKNVHTGPHIGSNIISNIDQSSSCSSSMLLSAT--------SNSNIGGGSSSSS---SSS 1626
            :.:   :.:......||::.:.....:...:|:.|..|        :.|....|.|..|   ||:
  Fly   748 LAE---QRIQEEVVQGSSLFATPSSRTPTPTSLALGTTAATPPIFEAKSCYAFGQSQGSVFPSST 809

  Fly  1627 SSTTLPACSSATTTTTASAL-TTSRGPVKNVTP------NNSNSSGHTSTNSCRSSNNSNNSSNS 1684
            ||..:|..|....:.....| |||.|.|..:||      .:|.|||..|..|.|.|..|....:.
  Fly   810 SSFQMPLSSPGFPSMQGIELPTTSAGIVAELTPVKRKKHKHSKSSGSDSRKSARCSKKSKKKRHH 874

  Fly  1685 SCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPPESY 1749
            |.                                            ::.|:.|       |.|
  Fly   875 SS--------------------------------------------SRQQFSA-------PAE-- 886

  Fly  1750 CASDEKLLDDQEQEAELELRLRLGLGLEKSHG---GQQHIEAYDLTCSTPPPVTVPQAAAVPRKA 1811
              .|..|.|||.|.   |||..|. .::.|:.   ||:.....|.:...       :.|.:.|:.
  Fly   887 --EDLDLQDDQLQS---ELRNALH-AVDPSYAQRFGQEVFSIMDNSMRM-------RLAKITRQY 938

  Fly  1812 RIGK------------------SMAREMVYAAQQQLLPEKQLKQPKEAAAKL--EAEP----EMP 1852
            |..|                  .:..:...|:||.:.|...|:||:...:.:  .:.|    :.|
  Fly   939 RKKKRKLDEISKHKKKKKCSKQQLELQQQQASQQAVQPSSALQQPQMTLSSVLGTSSPLRDYKFP 1003

  Fly  1853 FVLKAEIKAETKIKI---EHDGEAQASTHISQLPDLKPT-----------IKTEPEQELEQEAAS 1903
            ....:.::|.:.::.   .|......|...|| |:..|.           ::.|| ..|:...|.
  Fly  1004 KFSSSNLQASSFLRFPDKTHSFPPPPSLQQSQ-PEPNPLPSSSSPSTSSFVRLEP-SALDAAVAI 1066

  Fly  1904 VPSVAKTEPQ-----PEVEVEREQQEPPVD----EEQQPTPGGSKQRFNL----LALSSGN---K 1952
            .|:.:.|...     .:|...|:|::....    ..:|.....:|:||:.    |.|:|.:   .
  Fly  1067 APTTSSTSTSGSPSTKQVASARKQRKMKASTVGAAGEQTAATEAKRRFSAIDRELQLTSEHLYRD 1131

  Fly  1953 KTKTNNS-----YKSLIKQAEPK---SYLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRMRLQ 2009
            :|:....     |..::|...|.   |....|.|..:.|..:....:|...:.:..:..:.:.:.
  Fly  1132 ETRVLTDMGGLFYAGVMKPLRPPDVYSITLDGERGNKSHVMSREDILKDTILEVAPKSVESVPVG 1196

  Fly  2010 RR-----EQQQQRRQQREA--AAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNSSATPSASP 2067
            .|     .||.:......|  :.:||.|   |.|.|.|....|...||:..|...:
  Fly  1197 TRLCAYWSQQYRCLYPGRAIDSEQVVDG---TASSATNAATTAPDFVSVEFDDGDS--------- 1249

  Fly  2068 KRARPRKQEIAAL----HLLEGLDTTLSRGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDH 2128
              .|.|.|.|..|    .:.|..|..|           :|..||..:|:.|  ..|.|.....||
  Fly  1250 --GRIRLQNIRMLLSDYPIAEYNDNPL-----------YSVGKQKRSALRG--GESGPGGVTQDH 1299

  Fly  2129 RGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAAAT---------- 2183
                           ...|..|.|.|            ....|.....|...|||
  Fly  1300 ---------------LTVPGCEDSHS------------HHSLGMSSDNTTSLAATMELFTQRSEK 1337

  Fly  2184 -TIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTAS---- 2243
             .:..:.:..::|.|.::.:. .||..                  .||...|...|...|:
  Fly  1338 KRLKKSLKKMSKAQNGVSPAT-ATNGG------------------ADAAALGDGVSAEDAARKHH 1383

  Fly  2244 ----QQQNQQH-----SDEQHQFLVPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNR 2299
                ::::::|     |:||.|.:|...    .:.|...||..||.:..:..:.|.:...|....
  Fly  1384 KHKKRKKHKKHHRKNGSEEQEQQVVQQD----YSAAGQEATEAPSTEMSSATSSRVKVEVKVKTE 1444

  Fly  2300 KRQRHRPGGVSYELDVTQPPATKANVVPKWNNG---------------WMWAGKAFQGAVFLNSD 2349
            :.:.......|..:......| |.:.:.:.||.               |.|.|.|::.|.....
  Fly  1445 QLEMEEEESASNLMSEISDEA-KGDDLVEHNNSKGSSKIAAFLPERQLWGWYGTAYRKAGVKGR- 1507

  Fly  2350 DPLVLRTCYPAMRHVEGDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPE 2414
               ..:..|..::..: :.|.:.|..:..:....:.||:.::..:|:. ..|..::.:.|:|.||
  Fly  1508 ---ARKQFYKTIKRGK-ETITVGDSAVFLSTGRPDRPYIGRIESMWET-TTGNKVVRVAWFYHPE 1567

  Fly  2415 HTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEY 2455
            .| .|..:...|..::.|.|.|.|.|..:..:|.||.|..|
  Fly  1568 ET-TGCPKLKFPGALFESPHEDENDVQTISHRCEVLQFGSY 1607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_608360.2	BAH_BAHCC1	2366..2519	CDD:240065	23/90 (26%)
wge	NP_732790.3	PHA03247	<484..811	CDD:223021	82/428 (19%)
		Tudor_BAHCC1-like	1189..1265	CDD:410468	20/89 (22%)
		BAH_BAHCC1	1520..1642	CDD:240065	23/91 (25%)