DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hers and Bahcc1

DIOPT Version :9

Sequence 1:	NP_001245771.1	Gene:	Hers / 33000	FlyBaseID:	FBgn0052529	Length:	2529	Species:	Drosophila melanogaster
Sequence 2:	XP_038943741.1	Gene:	Bahcc1 / 360674	RGDID:	1306500	Length:	2651	Species:	Rattus norvegicus

Alignment Length:	2978	Identity:	568/2978 - (19%)
Similarity:	921/2978 - (30%)	Gaps:	854/2978 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSTATAAAAAAAAAAAATASSTQ-GKKRPGKQTKASGGGGDEADDKKSASKTDSAAKKPAKDPTG 78
            ||.|.||..|.|..||..|:..| ||..|.....||                .:|:.:...:|..
  Rat    23 RSAAAAARLAPAGPAAQPAAHFQPGKYFPSPLPMAS----------------HTASSRLMGNPPA 71

  Fly    79 SSGVSTATTEGGAGNGGGKQTTSTTTSSTSSTTAPSASASASASNSLKLSPEERHEDGKARAINK 143
            ||.:.:..|     :..|...::.....|||.:.|:...|..|::.:..|  ..||.......:.
  Rat    72 SSFMGSFLT-----SSLGSAASAHPNGPTSSPSEPAYRGSHPATSQIWFS--HSHEAPAYPRFSG 129

  Fly   144 MLKSLDIKI-----HGFDNLLPSGEERLNDGVLKSSI--------------SENVKTKSRAAAVK 189
            .|.|..:.:     ||..|:| .|:.|.. |..|.:.              :.|.....||....
  Rat   130 SLASTFLPVSHLDHHGNSNVL-YGQHRFY-GTQKDNFYLRNLPPQPAILPANHNFHGVPRATPTH 192

  Fly   190 VISSLNPGKMPPVKRVRPSPEPVR------------EKVAEKPAEKVLDKEKPKAEQQITPP--- 239
            .|.|.:..::......:...|..|            .||||.....|:::|..|..|::.||
  Rat   193 PIGSCSRDRIEAASLQKGPKEFDRFLMGKELGKEKASKVAEGRERPVVEEESSKDRQKLVPPMPA 257

  Fly   240 --PAPEESPASKVPKKTVQQAKKAKVESSLVQATVLTTTSAATSAPSSAS---TSKHTSTKNPGK 299
              |..|..||   |:.:.:...| .:.|.|:...||.......|..|.|.   ....|....||:
  Rat   258 EGPCKETGPA---PRGSCEGRPK-HLTSCLLNTKVLNGDMGKASMASCAGGMLGRPGTGVAAPGR 318

  Fly   300 KSAHSEQMPKKELSKLAKMGKPKKEANLVKSTARLPDSNTESVQMELEEIVSTPTVTPTPSATPT 364
            .:        ||:|...:.|....|.                  :|..:::........||..||
  Rat   319 CA--------KEVSGPVEPGPAFSEC------------------LERRQMLHHAVSYTVPSGLPT 357

  Fly   365 ATPTPTATPTLTPTPTATRTRTPTPTLTP----------TPTPTSTPSSTAIA------------ 407
            ..|.|.:|......|.......| ..|.|          ...||..||...:|
  Rat   358 GPPPPLSTGPAGSFPCLQLHAGP-DGLCPLQDKVSRDLKASGPTFVPSVGHLADKSHSFQVTEAC 421

  Fly   408 --AGQPAPPPPPPGGAPKQRP-KVKYTKTSAGSKGR-----MQQALNQK---------APAASWS 455
              ||...........||...| .|.|....|.|||.     .:.||:.:         .|.|.:.
  Rat   422 AVAGDGKDRHLDAAMAPDHAPYGVSYAHLKAESKGERRPGGFEAALHPRLKGLEYLSSGPEAPFP 486

  Fly   456 GAKDIYDFKSGSEDEEPIKMVLPSLKELREFSDEDNKPLKLFERQAEKTKVQVQDEE-------- 512
            |      ...|:.|:... ..||:.::....:.:|  ||.....||..|..:|.::|
  Rat   487 G------LPKGNLDKGGY-FELPTSQDCARSNHQD--PLGGKTTQACCTLDKVANKEAPAGPPGG 542

  Fly   513 --------EQPLVKKE-EKPPSEKEVKVKSKE---------------------------KEKEKE 541
                    :|.||..| |...|..|.|.||.|                           :|::..
  Rat   543 QKVARIRHQQHLVAPEVESGGSGAESKRKSVELASLGYSGHHMPPWGVQTGHDTSMAIIEERKGS 607

  Fly   542 KDVDPLSNAQQSEPAAKHTTSTSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKG------ 600
            ..:||..:..|..........|.....:::.::.|.:.:.:.      .|:|...||.|
  Rat   608 AYLDPFGSGLQQAALLSQELPTPQDEVSAMKNLLKYSNQALV------VGQKAPFVGLGGLKASC 666

  Fly   601 -----KAAAAKEP--------------------------PPSGSSAESSSSED--ERKLSAYS-- 630
                 |..|.|.|                          ||.|.:...:..:|  .|..:||:
  Rat   667 VQQEAKFPATKGPGPVERPDCARSREHEAPTHGDGEVRQPPVGIAVALARQKDTVSRPDAAYNTN 731

  Fly   631 ---------------GPKRHRMASLNALAKVQCLYENESRTAHE-LGLSKATQQPPRIRTLDGSD 679
                           ||:......|.:       .|..||...: |||      |.|...|..:.
  Rat   732 SGRQGRAAPTFKAAGGPRATHTLDLES-------EEERSRACEDRLGL------PGRELLLQDNK 783

  Fly   680 D-----DNHKDSPRHGDTDRDKGSVSPPHT---------SAAP---PAAPIAPPKEAEPRRELRY 727
            |     ..|..|...||.        |||.         ..||   ||.|...|:...|...:
  Rat   784 DLVEFARIHPSSSCPGDL--------PPHLMMQGGQLGGDPAPHPHPAHPHWLPRTRSPSLWM-- 838

  Fly   728 VPGGRGVG-----------------------KHWEFDSDSETE------------------ELQL 751
              ||...|                       ..:....|:.|:                  |:..
  Rat   839 --GGHSYGLGHPALHQNLPPGFPASVPGSMPSVFPLPQDAATQLVILPSEPTPHTTPHTLAEVMD 901

  Fly   752 QQTL-PPV-----------KKKKLPKKAPPKKVASSETDAKRKKKSVQVEESDDEEAKEKEKEKE 804
            |.:| ||:           ...:||..:..:.:...|..|.:.::..|.::...::.::::::::
  Rat   902 QASLWPPMYGARGPASHMQHPGQLPVYSRSQLLRQQELYALQHQQQQQQQQQQQQQQQQQQQQQQ 966

  Fly   805 KPKPPKQLPKKRKTAFTEELIGDYKGILARKRMASLNASAIVAATYEVERHLDKNLASDCSSFES 869
            :.:..:|..::::...|:.|              .|..:|......| :||::...|:...:.:|
  Rat   967 QQQQQQQQQQQQQHRATQAL--------------ELQRAAQFQRKPE-DRHMELEEAAREKAPKS 1016

  Fly   870 YDE---LDTMPTTTSKVTSAAAIKTEVIHIKKEPKESKESLRERERERESERRRERDNELKDSTV 931
            ..:   |..|...|...|:|..:|.       .|.....:|:..........|......|.....
  Rat  1017 THKPVALTPMAKGTPSSTTAGLVKL-------SPCCQSPTLKTPASCPTPPPRPSAPCTLPICPT 1074

  Fly   932 GKMSSHSIIEESNDSKYSKETKETNTDTTI----------TTTGYRDSAASTKDAKDCSRPTSSS 986
            |.....|.:..:.|.  |:|.:...||.|.          .:||...|..|...:.|...|.:
  Rat  1075 GSPGPGSKLPSTKDK--SEEGQRAGTDLTALEPDLPPRLNPSTGVDFSLPSDVHSSDLPDPKT-- 1135

  Fly   987 VVIVQDTDVTITGVYVNASNGAAQEAYCKMQYRVQSSVTEERVLRPGSVEP--PKSYTPLSALS- 1048
               :|.|           :.|...|              ..|...||...|  |::......||
  Rat  1136 ---MQTT-----------TPGTRPE--------------PTRTFLPGEPPPCSPRNLEEPGLLSR 1172

  Fly  1049 --------SMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHL------SAGMYHAPDLGLH 1099
                    ::|||....||....:..|.|:.    |...|..|:.|      :.|..::...|..
  Rat  1173 TRDATQDLAILPPPVEGGLPPGKAEDPSPLE----GLQALKFGDLLEGGGTEATGQTNSTQGGTQ 1233

  Fly  1100 TEHALPDHHGPPPPSYAAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHAAHAHHYQQAAE 1164
            .|..:  ..|.|.||..|...|....|         |....|......|.|...|.....:...|
  Rat  1234 NERTV--DQGVPQPSLGATPQALEQVA---------GSPVALDKDEGPQKAPDVAQLQEEETQLE 1287

  Fly  1165 YHGGPPPPPHHYGGPPPQGHYGPPPGAPVPVPVAVPNTVTVPPERCDVGSPPPSYRASAYPPPSS 1229
            .:||.....   .|.|...|   ||.|...:...|..||       |:|..|......|..|.:|
  Rat  1288 ENGGDSEVD---WGTPNHSH---PPKALPGLDALVAATV-------DLGDLPDISLPDAQTPAAS 1339

  Fly  1230 VGM---PPPTLGG--GSSAFCAPSPLHHHQH------------------QH-------------- 1257
            |.:   |.|...|  |.:.....:.|...|.                  ||
  Rat  1340 VPLGTAPQPHTSGIHGIALLSELADLEIQQQKSELALQAEDEDVLAFNLQHLATLATAWSLVEAA 1404

  Fly  1258 --QQPGPGVGPPHHDPSGYYQPAGPLISPHVIAAPPPPAQVKKLQEEDG---------PVSAAGS 1311
              ......:..|..||.     .||.::|          :::.||.:|.         |:.||..
  Rat  1405 SLDNSVASLQAPAADPD-----RGPRLTP----------RMQILQRKDTWAPKTKPVCPLKAAID 1454

  Fly  1312 PTQLQQQQAAAEAAAAAADQAAAQSQSQSQGQSHGHAHSHAH---------NPQQAQHPPQ-PQP 1366
            ....|:.:...:.|.........|.:.....:.|.|....:.         .|::.:|... |..
  Rat  1455 RLDTQEVEMRMQLAELQRRYKEKQRELARLQRRHDHEREESSRSPARRGPGRPRKRKHSSSLPAL 1519

  Fly  1367 YPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGYPPN-----YYAPYPG-------EVMCYSP 1419
            .|.|.:|.:.:..|  :.|..|.|:..|::....  ||.     ..:||.|       :|.| ..
  Rat  1520 RPGGQLARSDSKKA--KAVRASLSLLCAELRGDE--PPRKRSKLEKSPYTGLQTASSEKVRC-KK 1579

  Fly  1420 PTYPPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYYQHAGPPPPHELYEQQPPPPPVSSGSV 1484
            ...|...||.:      ||..|..:           |..:..|.|.....::::...|   .|.:
  Rat  1580 SCGPAELSSSM------AHKVAQLK-----------PKVKSKGLPASLSAFQRKEAAP---GGRI 1624

  Fly  1485 SGPAQQQPPTSSPASVGAAGAGTAGAPSG--SQLVPAHQQQHQQQHLEHYPGPPSYYAGYSPGGG 1547
                  :...|...||..:||.....|:|  .:.:|..|.|            |:....:..|.|
  Rat  1625 ------RKKLSRAKSVKVSGAARHPHPNGDSGREMPKFQTQ------------PAVAVAHEAGSG 1671

  Fly  1548 ASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKN----VHTGPHIGSNIISNIDQSSSCSSSM--- 1605
            ..:..|..      .:|         .::.|:.    :|.|..:|.:..|.:...::..:..
  Rat  1672 YDSEDCQA------LLE---------TEAAPREPGLVLHPGAVLGPSPSSVVKMEANQKAKKKKE 1721

  Fly  1606 ---LLSATSNSNIGGGSSSSSSSSSSTTLPACSSA--TTTTTASALTTSRGPVK---NVTPNNSN 1662
               ||.|...|:..|.......:..:...|....|  .....|.....::|..|   ...|.|:.
  Rat  1722 RQGLLGACRLSSPEGEVKIKRRTVKTKVGPKLERAPGRRPPGAPGKKKAKGKAKTGLRAEPGNAT 1786

  Fly  1663 SS----GHTSTNSCRSSNNSNNSSNSSCQTIE--MTSWATAATNTTSTTATTATTGTQCQMLVKT 1721
            |.    ..|.|.:||...:...|......|.:  |........|...:.|.:|...        .
  Rat  1787 SRDSLFNPTRTFACREEGSKLASERLKRATRKSAMLQPVLRRKNGALSIALSARNA--------K 1843

  Fly  1722 ELKGENPQVTKMQYEA-----------HVMPPPTPPESYCASDEKLLDD-----------QEQEA 1764
            .:.|::.::||:..||           .::      ||:...|:...||           :|:||
  Rat  1844 AILGKSRKLTKVNREAVSKQGQGRAVSRLL------ESFAVEDDFEFDDDDDSSFSDEEEEEEEA 1902

  Fly  1765 ELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARI--------------GK 1815
            .::|.......|.:|    ..|...||....  ||.:|:..::.....:              |:
  Rat  1903 GVQLSEEQSAALARS----CTIHKEDLQDGL--PVLIPKEDSLLYAGSVRTLQPPDIYSIVIEGE 1961

  Fly  1816 SMAREMVYAAQQQLLPEKQLKQPKEAAAKLEAEPEMPFVL------------------------- 1855
            ...|:.:|:. :|||.|          |.|:..|:....|
  Rat  1962 RGNRQRIYSL-EQLLQE----------AVLDVRPQSSRYLPPGTRVCAYWSQKSRCLYPGNVVRG 2015

  Fly  1856 -KAEIKAETKIKIEHDGEAQASTHISQLPDLKPTIK---TEPEQEL--------EQEAASVPSVA 1908
             .::.:....:.:|.|........:|.:..|.|..|   |||...|        .::|||
  Rat  2016 ASSDEEDLDSVVVEFDDGDTGHIAVSNIRLLPPDFKIQCTEPSPALLVSSSCRRTKKAAS----- 2075

  Fly  1909 KTEPQPEVEVEREQQEPPVDE--EQQPTPG---GSKQRFNLLALSSGNKKTKTNNSYKSLIKQAE 1968
              |..|..|.......|.|.:  |...|||   |.|.:...:.|.:...|:.|..|...|.::..
  Rat  2076 --ESHPPSEAPTPSLSPKVQDGPETSKTPGKKSGCKDKAGKVDLLTSGAKSPTGASDHFLGRRGS 2138

  Fly  1969 P-KSYLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRMRLQRREQQQQRRQQREAAAEVVAGAV 2032
            | .|:....:  .:|...|.|....:...:|....|.....::...:.........||.|...:.
  Rat  2139 PLLSWSAVAQ--TKRKAVAAAAAGGKGPGVLQNLFQLNGSTKKLRARDTLFPMHSMAAPVFGNSF 2201

  Fly  2033 -----------VTPSLAGNPIEQAGSEVSIVKDQAPNSSATPSASPKRA--------------RP 2072
                       .||.|.|......|....:::.:....:....|..:||              .|
  Rat  2202 RADSFSSLASSYTPFLGGAGAGLPGGAHKLLRAKKAERAEVEKAGRRRAGSEFLVKLDHEGVTSP 2266

  Fly  2073 RKQEIAALHLLE-----GLDTTLSRGYFSDPELNHSSRK-QAPT--AVGGLYAASSPLTTATDHR 2129
            :.:...||.:.:     .|...|:...::.|.|....:| :||.  ...||.....||...:|
  Rat  2267 KNKNCKALLMSDKDFGPKLGRPLASPSYTHPALIGKDKKGRAPVHPLHMGLALRKYPLPCDSD-- 2329

  Fly  2130 GKQTTAEKRSKSETKKPPSGESSESGLPCK-KPRKEPAGKVKGKGKKTTAGAAATTIASTAETQT 2193
                    ...|.:.:...|....:|:|.: ..|...:....|....:::|:.:|:...:::.:
  Rat  2330 --------CPSSYSDEDEDGPGLATGVPSRFLTRLSMSSSSSGSSTSSSSGSVSTSSLCSSDNE- 2385

  Fly  2194 EAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTASQQQNQQHSDEQHQFL 2258
                    .:..::::|..|..||....|..||:.....|..:..:|.      ..|:..|..||
  Rat  2386 --------DSSYSSDDEDPTLLLQTCLTRPVPALLAPPEALRSKGSSP------HAHAHAQRCFL 2436

  Fly  2259 VPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNRK----RQR-----HRPGGVSYELD 2314
                 :.|..|.|.|...|    |.:....:.:....|...|    |||     :|| .:|..|
  Rat  2437 -----SRAGVTGAGAGAGP----GVSKSKFKRKEALSFSKAKELSRRQRLPSVENRP-KISAFL- 2490

  Fly  2315 VTQPPATKANVVPKWNNGWMWAGKAFQGAVFLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLL 2377
                ||.:.         |.|:|...|..........|.    |.|:  |.| :.:||.|| |.|
  Rat  2491 ----PARQL---------WKWSGNPTQRRGMKGKARKLF----YKAI--VRGKETLRIGDCAVFL 2536

  Fly  2378 KANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVAC 2442
            .|...| |||:.::..||:: ....|::.:.|:|.||.|..|::::|..:.:|.|.|.|.|.|..
  Rat  2537 SAGRPN-LPYIGRIESLWES-WGSNMVVKVKWFYHPEETKLGKRQSDGKNALYQSCHEDENDVQT 2599

  Fly  2443 VEDKCYVLTFSEYCRYRRRLRAAE-EDVEDVSIV-----PRRPSIATAPGFPV 2489
            :..||.|:...:   |.:.:|..: :|.:|:..:     |....:.||.|.||
  Rat  2600 ISHKCQVVGREQ---YEQMMRGRKYQDQQDLYYLAGTYDPTTGRLVTADGVPV 2649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	41/132 (31%)
Bahcc1	XP_038943741.1	Herpes_BLLF1	<1014..>1253	CDD:282904	55/283 (19%)
		PRK10246	<1366..>1485	CDD:182330	18/133 (14%)
		Tudor_BAHCC1	1984..2051	CDD:410541	7/66 (11%)
		BAH_BAHCC1	2524..2643	CDD:240065	35/123 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910