Protein Alignment Hers and BAHD1

DIOPT Version :10

• Sequence 1: NP_608360.2
• Gene: Hers / 33000
• FlyBaseID: FBgn0052529
• Length: 2529
• Species: Drosophila melanogaster
• Sequence 2: XP_011519668.2
• Gene: BAHD1 / 22893
• HGNCID: 29153
• Length: 832
• Species: Homo sapiens
• Alignment Length: 1060
• Identity: 246/1060 - (23%)
• Similarity: 360/1060 - (33%)
• Gaps: 363/1060 - (34%)

  Fly  1586 HIGSNIISNIDQSSSCSSSM-------LLSATSN-SNIGGGSSSSSSSSSSTTLPACSSATTTTT 1642
            |..|.:.|:| |...|...:       |..|||. |.:..|...|.:.:...:||..|
Human     9 HSSSPLCSSI-QEDLCVFILSVLIPLGLAPATSGLSTLSQGWKYSMTHTRRKSLPMLS------- 65

  Fly  1643 ASALTTSRGP-----------VKNVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWAT 1696
             |.||..|.|           |:.|.|....|.||.          :....|...:...:.....
Human    66 -SGLTGRREPLQMEDSNMEQGVEGVEPGMPESPGHL----------TGRRKNYPLRKRPLVPEKP 119

  Fly  1697 AATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPP--PTPPESYCASDE----- 1754
            .|                |::|: |.|  ||....:...||..:||  |.||....:|::
Human   120 KA----------------CKVLL-TRL--ENVAGPRSADEADELPPDLPKPPSPAPSSEDPGLAQ 165

  Fly  1755 ---------------KLLDDQEQEAELELRLRLGLGLEKSHGGQQHIE----------------- 1787
                           .||.::|..:.|       .|..:|..|..|..
Human   166 PRKRRLASLNAEALNNLLLEREDTSSL-------AGTRRSRAGDPHRSRDRDRATGGWSSSKKRP 223

  Fly  1788 --------AYDLTCSTPPPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAK 1844
                    :.||: ..|.|...|:....|...|:....|...:..:|::.||   |:.|: |.|:
Human   224 RLGDLGGGSRDLS-PEPAPDEGPRRDGDPAPKRLASLNAAAFLKLSQERELP---LRLPR-AHAE 283

  Fly  1845 LEAEPEMPFVLKAEIKAETKIKIEH---------DGEAQASTHISQLPD--------LKPTIKTE 1892
            ::.....|...||......|:..::         .|||.........||        ..|::  :
Human   284 VDGRSTEPPAPKAPRPKWPKVNGKNYPKAWQGASSGEAAGPPGWQGCPDEPWPSATPCGPSV--Q 346

  Fly  1893 PEQELEQEAASVP------------SVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNLL 1945
            |..:...:|...|            ..|..:|:|    .|..:|.|..:::...|.....:.:.|
Human   347 PSHQPLSKALESPLGLRPHLPLLMGGQAALKPEP----GRPGEESPAPKQELHQPSFPTPQLSPL 407

  Fly  1946 ALSSGNKKTKTNNSYKSLIKQAEPKS----YLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRM 2006
            .: .||..     .|..|....|..:    ||..|:..::..|.:|...:...::
Human   408 PM-PGNPA-----DYNGLCVGPELTALGSFYLYCGQEGLQCGGYSPCPMLPEGKL---------- 456

  Fly  2007 RLQRREQQQQRRQQREAAAEVVAGAVVTPSL--AGNPIEQ---AGSEVSIVKDQAPNS------- 2059
                          ...||....|.::.||.  :|.|.:.   ..|.....:|...|.
Human   457 --------------SPVAAPHEEGLLLAPSSVPSGTPFQHPPWGSSRYCSSEDTGVNGYSICGVL 507

  Fly  2060 --SATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAP---TAVGGLYAAS 2119
              |.|.:.:.....|.|...||    ||. .:|.:..|..||..|.:....|   ..|..:..|:
Human   508 PLSVTHAGTTCGGCPYKMPFAA----EGC-RSLGQLEFPLPEAGHPASPAHPLLGCPVPSVPPAA 567

  Fly  2120 SP---LTTATDHRGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAA 2181
            .|   |.|.|..  .||.|  |:..::.|||||  |:|||
Human   568 EPVPHLQTPTSE--PQTVA--RACPQSAKPPSG--SKSGL------------------------- 601

  Fly  2182 ATTIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTASQQQ 2246
                                                             :...:...|:.:...:
Human   602 -------------------------------------------------RTGSSCRHTARSKAAR 617

  Fly  2247 NQQHSDEQHQFLVPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNRKRQRHRPGGVSY 2311
            ...|         |.||                      ..:|.|.      |:|:|.|
Human   618 RPSH---------PKQP----------------------RVQRPRP------RRRRRRR------ 639

  Fly  2312 ELDVTQPPATKANVVPKWNNGWMWAGKAFQGAVFLNSDDPLVLRTCYPAM-RHVEGDIIRIRDCV 2375
                              .|||:..|.|.:.||::..:....:|..|.|: ||  |:.||:||.|
Human   640 ------------------TNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERH--GETIRVRDTV 684

  Fly  2376 LLKAN-EDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGR---QRNDCPDEVYASRHRD 2436
            |||:. .....|||||::.||:|||.||:||||||||||||...||   ......:||:||||:|
Human   685 LLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQD 749

  Fly  2437 HNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDV--EDVSIVPRRPSIATAPGFPVRTVPEHTNPE 2499
            .|||||:|:|||||||:||||:....:...|.:  ...::||.....:|.|.   |||||.|:||
Human   750 QNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSADYSTPPH---RTVPEDTDPE 811

  Fly  2500 LVMFCRRAYEFRTRRLLKLP 2519
            ||..||..|:||..|:||.|
Human   812 LVFLCRHVYDFRHGRILKNP 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_608360.2	BAH_BAHCC1	2366..2519	CDD:240065	82/158 (52%)
BAHD1	XP_011519668.2	PHA03247	<329..597	CDD:223021	63/314 (20%)
		BAH_BAHCC1	675..785	CDD:240065	60/109 (55%)