DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hers and BAHD1

DIOPT Version :9

Sequence 1:	NP_001245771.1	Gene:	Hers / 33000	FlyBaseID:	FBgn0052529	Length:	2529	Species:	Drosophila melanogaster
Sequence 2:	XP_011519668.2	Gene:	BAHD1 / 22893	HGNCID:	29153	Length:	832	Species:	Homo sapiens

Alignment Length:	1060	Identity:	246/1060 - (23%)
Similarity:	360/1060 - (33%)	Gaps:	363/1060 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1586 HIGSNIISNIDQSSSCSSSM-------LLSATSN-SNIGGGSSSSSSSSSSTTLPACSSATTTTT 1642
            |..|.:.|:| |...|...:       |..|||. |.:..|...|.:.:...:||..|
Human     9 HSSSPLCSSI-QEDLCVFILSVLIPLGLAPATSGLSTLSQGWKYSMTHTRRKSLPMLS------- 65

  Fly  1643 ASALTTSRGP-----------VKNVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWAT 1696
             |.||..|.|           |:.|.|....|.||.          :....|...:...:.....
Human    66 -SGLTGRREPLQMEDSNMEQGVEGVEPGMPESPGHL----------TGRRKNYPLRKRPLVPEKP 119

  Fly  1697 AATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPP--PTPPESYCASDE----- 1754
            .|                |::|: |.|  ||....:...||..:||  |.||....:|::
Human   120 KA----------------CKVLL-TRL--ENVAGPRSADEADELPPDLPKPPSPAPSSEDPGLAQ 165

  Fly  1755 ---------------KLLDDQEQEAELELRLRLGLGLEKSHGGQQHIE----------------- 1787
                           .||.::|..:.|       .|..:|..|..|..
Human   166 PRKRRLASLNAEALNNLLLEREDTSSL-------AGTRRSRAGDPHRSRDRDRATGGWSSSKKRP 223

  Fly  1788 --------AYDLTCSTPPPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAK 1844
                    :.||: ..|.|...|:....|...|:....|...:..:|::.||   |:.|: |.|:
Human   224 RLGDLGGGSRDLS-PEPAPDEGPRRDGDPAPKRLASLNAAAFLKLSQERELP---LRLPR-AHAE 283

  Fly  1845 LEAEPEMPFVLKAEIKAETKIKIEH---------DGEAQASTHISQLPD--------LKPTIKTE 1892
            ::.....|...||......|:..::         .|||.........||        ..|::  :
Human   284 VDGRSTEPPAPKAPRPKWPKVNGKNYPKAWQGASSGEAAGPPGWQGCPDEPWPSATPCGPSV--Q 346

  Fly  1893 PEQELEQEAASVP------------SVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNLL 1945
            |..:...:|...|            ..|..:|:|    .|..:|.|..:::...|.....:.:.|
Human   347 PSHQPLSKALESPLGLRPHLPLLMGGQAALKPEP----GRPGEESPAPKQELHQPSFPTPQLSPL 407

  Fly  1946 ALSSGNKKTKTNNSYKSLIKQAEPKS----YLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRM 2006
            .: .||..     .|..|....|..:    ||..|:..::..|.:|...:...::
Human   408 PM-PGNPA-----DYNGLCVGPELTALGSFYLYCGQEGLQCGGYSPCPMLPEGKL---------- 456

  Fly  2007 RLQRREQQQQRRQQREAAAEVVAGAVVTPSL--AGNPIEQ---AGSEVSIVKDQAPNS------- 2059
                          ...||....|.::.||.  :|.|.:.   ..|.....:|...|.
Human   457 --------------SPVAAPHEEGLLLAPSSVPSGTPFQHPPWGSSRYCSSEDTGVNGYSICGVL 507

  Fly  2060 --SATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAP---TAVGGLYAAS 2119
              |.|.:.:.....|.|...||    ||. .:|.:..|..||..|.:....|   ..|..:..|:
Human   508 PLSVTHAGTTCGGCPYKMPFAA----EGC-RSLGQLEFPLPEAGHPASPAHPLLGCPVPSVPPAA 567

  Fly  2120 SP---LTTATDHRGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAA 2181
            .|   |.|.|..  .||.|  |:..::.|||||  |:|||
Human   568 EPVPHLQTPTSE--PQTVA--RACPQSAKPPSG--SKSGL------------------------- 601

  Fly  2182 ATTIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTASQQQ 2246
                                                             :...:...|:.:...:
Human   602 -------------------------------------------------RTGSSCRHTARSKAAR 617

  Fly  2247 NQQHSDEQHQFLVPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNRKRQRHRPGGVSY 2311
            ...|         |.||                      ..:|.|.      |:|:|.|
Human   618 RPSH---------PKQP----------------------RVQRPRP------RRRRRRR------ 639

  Fly  2312 ELDVTQPPATKANVVPKWNNGWMWAGKAFQGAVFLNSDDPLVLRTCYPAM-RHVEGDIIRIRDCV 2375
                              .|||:..|.|.:.||::..:....:|..|.|: ||  |:.||:||.|
Human   640 ------------------TNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERH--GETIRVRDTV 684

  Fly  2376 LLKAN-EDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGR---QRNDCPDEVYASRHRD 2436
            |||:. .....|||||::.||:|||.||:||||||||||||...||   ......:||:||||:|
Human   685 LLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQD 749

  Fly  2437 HNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDV--EDVSIVPRRPSIATAPGFPVRTVPEHTNPE 2499
            .|||||:|:|||||||:||||:....:...|.:  ...::||.....:|.|.   |||||.|:||
Human   750 QNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSADYSTPPH---RTVPEDTDPE 811

  Fly  2500 LVMFCRRAYEFRTRRLLKLP 2519
            ||..||..|:||..|:||.|
Human   812 LVFLCRHVYDFRHGRILKNP 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	82/158 (52%)
BAHD1	XP_011519668.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5708
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005583
OrthoInspector	1	1.000	-	-		oto89071
orthoMCL	1	0.900	-	-		OOG6_107965
Panther	1	1.100	-	-	LDO	PTHR46576
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5045
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.890