DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hers and tnrc18

DIOPT Version :9

Sequence 1:NP_001245771.1 Gene:Hers / 33000 FlyBaseID:FBgn0052529 Length:2529 Species:Drosophila melanogaster
Sequence 2:XP_031748724.1 Gene:tnrc18 / 100491423 XenbaseID:XB-GENE-6458544 Length:2889 Species:Xenopus tropicalis


Alignment Length:2915 Identity:496/2915 - (17%)
Similarity:872/2915 - (29%) Gaps:1002/2915 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 NAAERVQRST--ATAAAAAAAAAAAATASSTQGKKRPGKQTKASGGGGDEADD------------ 58
            |..|.:..||  .|:|.......:.:.|..|...:..||: .|.||.|....|            
 Frog   542 NGTESLNPSTLGETSAMQNLIKYSGSFAKETAAWQGGGKK-NAFGGLGTMKSDTVDFNNVKNQQC 605

  Fly    59 -KKSASKTD----SAAKKPAKDPTGSSG------------VSTATTEGGAGNGGGKQTTSTTTSS 106
             ..|..|.|    .:||...::..|:.|            |:.|..:..:|            |.
 Frog   606 LSHSGGKRDPERSESAKSFGREVIGAQGEVEVRHPPVGIAVAVARQKDNSG------------SK 658

  Fly   107 TSSTTAPSASASASASNSLKLSPEERHEDGKARAINKMLKSLDIK----------IHGFDNLLP- 160
            |.|:..|            :.|.|..||..:.|....::..|:.:          ...|..:.| 
 Frog   659 TGSSKGP------------EQSEENGHEQIRHREDRLLMGRLECEQEKLLRERKDFADFSRIHPT 711

  Fly   161 -SGEERLNDGV-------LKSSISENVKTKSRAAAVKVISSLNPGKMPPVKRV-RP---SPEPVR 213
             ||...||..:       |.::......:.|:.||.   :..:.|..||:... .|   |.:.:.
 Frog   712 GSGANGLNSNLMVTGGPTLNTTGHWPADSTSQLAAQ---TWFHRGTTPPMWFTGHPYGFSHQTLH 773

  Fly   214 EKVAE--KPAEKVLDKEKPKAEQQITPPPAPEESPASKVPKKTVQQAKKAKVESSLVQATVLTTT 276
            :.::.  .|.   :....|.|.|.:..   |:......||.:.:...:.....|:|.||....|.
 Frog   774 QGLSGTFTPG---MTSSLPSAYQFVRD---PQTGQIVVVPSEQLSHFEILDRSSALWQAMYSPTR 832

  Fly   277 SAATSAPSSASTSKHTSTKNP-----GKKSAH-----------------SEQMPKKELSKLAKMG 319
            |:...|......|:....:..     .:::||                 |.|:...||.:.|::.
 Frog   833 SSLQHAHQLQLLSQQQLLRQHELYMLQQQAAHALELQRSAQLDALELQRSAQLDALELQRSAQLD 897

  Fly   320 --KPKKEANL----VKSTARLPDS-----------------NTESVQMELEE----IVSTPTVTP 357
              :.::..||    ::.|:.|.:|                 ||.:.:..||.    :..|..:..
 Frog   898 ALELQRTVNLDALDLQRTSPLVESFKVYEQQTEVENKIAKQNTGTCKQRLESHPNLLKQTVLLPS 962

  Fly   358 TPSATPTATPTPTATPTLTPTPTATRTRTPTPTLTPTPTPTSTPSSTAIAAGQPAPPPP----PP 418
            .||:...:..:|..:|...|....|:           ..||.......::...|:..||    ||
 Frog   963 APSSYSKSLSSPPLSPKAIPKSEHTQ-----------EGPTQEEHYEYLSNSHPSTTPPESSLPP 1016

  Fly   419 GGAPKQRPKVKYTKTSAGSKGRMQQALNQKAPAASWSGAKDIYDFKSGSE-------------DE 470
            ......|..:...:....|...      :|...:|::|.  :.|..||.:             ..
 Frog  1017 TALIATREDICDEEAEKNSTDM------EKGSTSSFTGL--LTDLSSGFQFSPISPSFENHAYPV 1073

  Fly   471 EP----------IKMVLPSLKELREFSDEDNKPLKLFERQAEKTKVQVQDEEEQPLVKKE----- 520
            :|          :.:.||::|::...|:.:...|.:.:....:.....:.:..:.|:..|     
 Frog  1074 QPTSGPNVACSNLDLPLPAVKKMENTSEANTNQLVISKLLEPEVPASAEKKPSETLLNSETLNHQ 1138

  Fly   521 ------------EKPPSEKEVKVKSKEKE-KEKEKDVDPLSNAQ----QSEPAAKHTTSTSTT-S 567
                        |....|.::::|::... .:|:....|:....    :|....|.|.||.|. |
 Frog  1139 TLCISSADEISAEDAEYEHDLQLKNETSNFNDKKYQEQPVCETDCFSVRSLKPGKETCSTQTDFS 1203

  Fly   568 TTSITSVKKQAKRKIATP----MPSSAGRKKKTVGKGKAAAAKEPPPSGSSAESSSSEDERKLSA 628
            ::.|||.|.|....|.:.    .||:..||.....:.:.:|...|......:::..||.::  ..
 Frog  1204 SSFITSDKCQVNLVIHSQSSEIFPSTNDRKILNTLRNEESAHSIPVVMRPISDTKFSEMDK--VT 1266

  Fly   629 YSGPK--------RHRMASLNALAKVQCLYENESRTAHELGLSKATQQPPRIRTLDGSDDDNHKD 685
            |..|:        ...:|.:|||.                   .||:.|              :.
 Frog  1267 YELPRTIPMDIIAEDPLAGMNALV-------------------AATEMP--------------EA 1298

  Fly   686 SPRHGDTDRDKGSVSPPHTSAAPPAAPIA---PPKEAEPRRELRYVPGGRGVGKHWEFDS----- 742
            ||:   ..:||  :..|..:..|....||   ...|.|..:..:.:...:........:|     
 Frog  1299 SPQ---VSKDK--LFLPDINTNPVLQGIALLSEMAEIELEKRKKELENQQNCHSQTSLESLLAAS 1358

  Fly   743 -------------DS-ETEELQLQQTLPPVKKKK-LPKKAPPKKVASS-------ETD------- 778
                         || :.|.:||.:.|.|.||.. :.|:.....:.||       |.|       
 Frog  1359 SQMLMEVLSCPVLDSLKAESIQLPRELNPDKKYSWMQKRDETFSIRSSIENMDSVELDYRLRLAE 1423

  Fly   779 -----AKRKKKSVQVEESDDEEAKEKEKEKEKPKPPKQLPKKRKTAFTEELIGDYKGILARKRMA 838
                 .:::::..:::...|.|.|:.||.....:.....|:|||                     
 Frog  1424 LQRMYKQKQRELTKLQRRRDSEEKQDEKNINLARRGPGRPRKRK--------------------- 1467

  Fly   839 SLNASAIVAATYEVERHLDKNL-ASDCSSFESYDEL--DTMPTTTSKVTSA------AAIKTEVI 894
              :.::.:.:..|.||...||: ...|..|....|:  |.:....:.:..|      ..||..:.
 Frog  1468 --HETSSMCSHLERERSETKNIKLKKCLLFSEDSEVGEDVLRRQMNVIEDAMIENVGGKIKNRIR 1530

  Fly   895 HIKKEPKESKES--LRERERERESERRRERDNELKDSTVGKMSSHSI-------IEESNDSKYSK 950
            ..:.:.:.|..:  :..:.|:::....:|..|:| |.::......::       .......||..
 Frog  1531 SWEDDARASSYTCEVLTQSRKKQKSSNQELANKL-DKSLSFTKQENVKSKFKFAFSSGGSQKYEG 1594

  Fly   951 ETKETNTDTTITTTGYRDSAA-------STKDAKDCSRPTSSSVVIVQDTDVTITGVYVNASNGA 1008
            .:|.      :|||.::::..       |.:.........:..|::      .:.| .:|.|:..
 Frog  1595 NSKH------LTTTEFKENKTLRFPMLISNEGKNKMVSKVNMHVIL------KVKG-QINTSHSP 1646

  Fly  1009 AQEAYCKMQYRVQSSVTEERVLRPGSVEPPKSYTPLSALSSMLP------PGASSGLSEAHSS-- 1065
            |........|...:. .||..||...|.|..|....|::.||||      .|.......|.||  
 Frog  1647 AFSEISNYSYYTDTE-EEEDYLRNELVSPSNSRLVQSSMYSMLPRRIKMTRGCLQSTERAISSCS 1710

  Fly  1066 -PPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHALPDH--------HGPPPPSYAAAAAA 1121
             .....:.:......||....:.:....:.:..:..:....:.        |.|.|         
 Frog  1711 TVKTKQNCSKNKQLSLLQDAEVRSSFSDSTEDSIDQDFTSEEEDCVNYGTDHLPSP--------- 1766

  Fly  1122 AAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHAAHAHHYQQAAEYHGGPPPPPHHYGGPPPQGHYG 1186
                      .:...|.|:|        |..||.                               
 Frog  1767 ----------NMDESGLGLL--------ARFAAS------------------------------- 1782

  Fly  1187 PPPGAPVPVPVAVPNTVTVPP-----------------ERCDVGS------PPPSYRASAYPPPS 1228
                       .:||.||..|                 .:|.:||      .....:....|.||
 Frog  1783 -----------VLPNPVTSSPISIIQLEAKQKAKKKEERQCLIGSEFQYSDSERELKVVRNPSPS 1836

  Fly  1229 SV---------GMPPPTLGGGSSAFCAPSPLHHHQHQHQQPGPGVGPPHHDPSGYYQPAGPLISP 1284
            :|         .:|..|    ....|..|                           ...|.::. 
 Frog  1837 TVLTSSLEVESALPVLT----EEETCVKS---------------------------LKKGSIMD- 1869

  Fly  1285 HVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQSQSQGQSHGHAH 1349
                   .|.::||.:          ||..|.::                ..|..|.....|...
 Frog  1870 -------RPRKIKKFK----------SPRNLSEE----------------FGQEVSDDDQWGRRR 1901

  Fly  1350 SHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGYPPNYYAPYPGEV 1414
            |.......|.:|....|.|...|.:            .|:|....:|  :|      .:|..|..
 Frog  1902 SERIFLNDAVNPSSLLPVPTNDVNS------------MSKSNRYTKM--AT------VSPKKGNQ 1946

  Fly  1415 M---CYSPPTYPPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYYQHAGPPPPHELYEQQPPP 1476
            .   |        .||::.: |..|.....|.:...|.   ||                      
 Frog  1947 RKDHC--------KFSTQAW-PLQPTGDTRHGEKGEPG---RR---------------------- 1977

  Fly  1477 PPVSSGSVSGPAQQQPPTS-SPASVGAAGAGTAGAPSGSQLVPAHQQQHQQQHLEHYPGPPSYYA 1540
                 |....|.:|...|. :..|:...|..|   ||....:....::|:::             
 Frog  1978 -----GRWQTPTRQTKMTEINICSLNVKGLNT---PSKRYKLCREMKRHKKK------------- 2021

  Fly  1541 GYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIISNIDQSSS--CS- 1602
                           :|     .|..|.|..|           ...:.|..:|.::.:||  || 
 Frog  2022 ---------------KG-----KELMPSCLSP-----------NGTLASVSVSRLNMTSSVTCSR 2055

  Fly  1603 SSMLLSATSN---SNIGGGSSSSSSSSSSTTLPACSSATTTTTASALTTSRGPVKNVTPNNSNS- 1663
            .:.|.|.|.:   .|.|.|.:                      .|.|..|....::..||..:| 
 Frog  2056 KTKLKSKTKDMKKENRGKGGA----------------------VSKLMESMAAEEDFEPNQDSSF 2098

  Fly  1664 SGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGE-- 1726
            |...:...|......|..:..||                              ::.|.|||..  
 Frog  2099 SEDENVPLCLHPERPNTPAPRSC------------------------------IIDKEELKDGLR 2133

  Fly  1727 --NPQVTKMQYEAHVMPPPTP--------------PESYCAS---DEKLLD-------------- 1758
              .|...|:.|..||....:|              |..||..   .|.::|              
 Frog  2134 VLIPMDDKLLYAGHVQTVHSPDIYRVIIEGERGNRPHIYCQEQLLQEAIIDVKPPSIRFLPEGTR 2198

  Fly  1759 ----------------------DQEQEAELELRLRLGLGLEKSHGGQ---QHIEA----YDLTCS 1794
                                  ||:::::|     :.:..:....|:   .||..    |.:.|:
 Frog  2199 IAAYWSQQYRCLYPGTVVQGSLDQKEDSDL-----ITVEFDDGDTGRIPLSHIRLLPPDYKIQCA 2258

  Fly  1795 TP-PPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAKLEAEPEM-PFVLKA 1857
            .| |.:.||.|....||:...:..|:|......:::..:.:.:..|:...::..|..: ...:..
 Frog  2259 EPSPALLVPSAKPRSRKSSKEQVEAKEAGSTGCEEVSVKSKSRGRKQNLKQITGETIINEDTVDK 2323

  Fly  1858 EIKAETKIKIEHDGEAQAS----THISQLPDLKPTIKTEPEQELEQEAASVPSVAKTEPQPEVEV 1918
            |....|||.:|....:|.|    |.|.|:|                                   
 Frog  2324 ESLLSTKICLEKHESSQTSIKLGTKILQIP----------------------------------- 2353

  Fly  1919 EREQQEPPVDEEQQPTPGGSKQRFNLLALSSGNKKTKTNNSYKSLIKQAEPKSYLCPGRRFIR-R 1982
                      ||..||.|..|.|        ..::.||       .|....|..:..||...: .
 Frog  2354 ----------EENSPTHGTPKIR--------KPEQMKT-------AKLCNAKQTIYTGRTLGKVE 2393

  Fly  1983 HGRAPAKYVKRRQMILTQRQQQRMRLQRREQQ--------QQRRQQREAAAEVVAGAVVTPSLAG 2039
            :|..|....    :.|..:.:...::::.|:|        :|.:.:.:...::....|::|    
 Frog  2394 NGNPPCDLT----VNLFDQLEDTKKIRKLEEQRDFVSLSTKQGKAENDFFVKLDHEGVMSP---- 2450

  Fly  2040 NPIEQAGSEVSIVKDQAPNSSATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSS 2104
                                      ..|:|:      .|:..||....|:              
 Frog  2451 --------------------------KTKKAK------EAMMWLEDASVTM-------------- 2469

  Fly  2105 RKQAPTAVGGLYA-----ASSPLTTATDHRGKQTTA---EKRSKSETKKPPSGESSESGLPCKKP 2161
            :|.....:|..||     :...|:.:..|..|.|||   |..|.|..|.....:..:..|   .|
 Frog  2470 KKTRKCIMGVSYAPVKHESKQKLSRSKPHLAKHTTACDSEALSSSLDKYKKKSDQKQGLL---DP 2531

  Fly  2162 RKEPAG-----KVKGKGKKTTAGAAATTIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKF 2221
            |:|..|     :.:|:..|......|....|::.:|:.....::.|:..|:::...::.      
 Frog  2532 REESDGSSSNSESEGEEDKENKQKQAQGDESSSSSQSSTSVCLSKSSSGTSSSSSSSSS------ 2590

  Fly  2222 RECPAVTDAKVAGTATSTSTASQQQNQQHSDEQHQFLVPSQPATASATAALAATPPPSRQG--QA 2284
            ..|.: :.|..:.:::|:||..:..:....||..:  :.|.|.....:....:..|..:.|  |.
 Frog  2591 SSCSS-SSASSSSSSSSSSTTDEDSSSTSEDETQE--LTSNPTNLQISLQKGSIKPAIKPGTPQI 2652

  Fly  2285 THTKRTRSRCKFGNRKRQRHRPGGVSYELDVTQPPATKANVVPKWNNG------------WMWAG 2337
            .:.::.:...|.|::...:.|.|   ..|..|:..| |...:|...|.            |.|.|
 Frog  2653 QNQRQKKQEQKKGSKNTPKKREG---IHLPTTKELA-KRQRLPSVENRPKIAAFLPARQLWKWFG 2713

  Fly  2338 KAFQGAVFLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLLKANEDNELPYVAKVAHLWQNPED 2400
            |..|..........|.    |.|:  |.| :||||.|| |.|.|...| |||:.::..:|:: ..
 Frog  2714 KPTQRRGMKGKARKLF----YKAI--VRGKEIIRIGDCAVFLSAGRPN-LPYIGRIQSMWES-WG 2770

  Fly  2401 GEMMMSLLWYYRPEHTDQGRQRNDCPD-------------------------EVYASRHRDHNSV 2440
            ..|::.:.|:|.||.|:.|::.||...                         .:|.|.|.|.|.|
 Frog  2771 NNMVVRVKWFYHPEETNPGKKLNDTKSWDQKSGKSSLSGLQMSSLRKDFMERALYQSSHVDENDV 2835

  Fly  2441 ACVEDKCYVLTFSEYCRYRRRLRAAE-EDVEDV-----SIVPRRPSIATAPGFPV 2489
            ..|..||.|:...:   |.:.|:..: :|.||:     :..|....|....|.||
 Frog  2836 QTVSHKCLVVALEQ---YEQMLKTKKYQDSEDLYYLAGTYEPTTGMIFNTDGVPV 2887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HersNP_001245771.1 BAH_BAHCC1 2366..2519 CDD:240065 44/157 (28%)
tnrc18XP_031748724.1 Tudor_TNRC18 2189..2255 CDD:410540 7/70 (10%)
BAH_BAHCC1 2737..2881 CDD:240065 40/148 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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