DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zld and sqz

DIOPT Version :9

Sequence 1:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_524403.1	Gene:	sqz / 42300	FlyBaseID:	FBgn0010768	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	107/453 - (23%)
Similarity:	168/453 - (37%)	Gaps:	111/453 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1192 LTTALHAHQQGGQQEAQTPTLTVLSTPYSP-TVSSSRATPALEMDMAT---LMQHHQDYEME--- 1249
            ||||...|.                  |.| .:|..|...|..:|.:.   |:||.|...||
  Fly    30 LTTAQLVHD------------------YKPFNISEFRQNVAERLDYSLKNGLVQHQQQMVMEQQP 76

  Fly  1250 ---QYQMQHQQLDQMQQHQQQL------------DHQQQQQILADQTQTMAQQPLAKKRRGGNAT 1299
               |.|.||....|.|||..||            .|:||:| ..|..::..:|.::.....|:..
  Fly    77 HPDQQQQQHLHHPQQQQHPPQLKVSYSAPNSPPTPHEQQEQ-KYDPNRSPPRQQMSSASGSGSNG 140

  Fly  1300 PSTTKRRRNSSVGSTSPHSTTLPSGRIKCLECDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRF 1364
            .|..:..|........|:         ||..|.|.|..:.||:||.: .|.|..|:||:.|.::|
  Fly   141 SSPEEESRRGDGDQAKPY---------KCGSCSKSFANSSYLSQHTR-IHLGIKPYRCEICQRKF 195

  Fly  1365 QSEDVYTTHLGRH---RTQDKPHKCEL--CPKQFH-----------HKTD--------------- 1398
                ...:||.:|   .|.|||:||..  |||.|.           |:||
  Fly   196 ----TQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDE 256

  Fly  1399 ------LRRHVEAIHTGLKQHMCDICEKGFCRKDHLRKHLETHNRPRVVGKKSAAAAAAAAAAAA 1457
                  :.:|.::.|  ||.|:|::|.|.:.::.:|:|||:.|  .....|:.....|..||...
  Fly   257 MTLLEHIPKHKDSKH--LKTHICNLCGKSYTQETYLQKHLQKH--AEKAEKQQHRHTAQVAAHQQ 317

  Fly  1458 VTATAGLG---GAPAAGSIKAAF---------ARSLTVTAVSSEPGAGVAIPSAPATATCAPVSV 1510
            ....:|:|   ...|...:.||:         |.||........|.|| ..|.....:.......
  Fly   318 HVPASGIGLNLQRQAMNDVNAAYWAKMGADSAAASLAEAIQQQLPQAG-GQPYGNFASLQQQHQQ 381

  Fly  1511 SASALVQAVNPSLTSGLSLKRHIDDVAVDDDSLLEEDEDEMEMEMEMDMLEEEDEEEEELGDH 1573
            ....|:.....:.|.|.|...|  :.|..:|.:|.:...:..::.:....:::..::::...|
  Fly   382 QQQELLHHQRLADTPGHSHSPH--EEAAGEDLVLRQSTPQHHLQQQQQQQQQQQAQQQQQAQH 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	24/65 (37%)
		C2H2 Zn finger	1328..1349	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1357..1377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1386..1407	CDD:275368	9/54 (17%)
		zf-H2C2_2	1398..1422	CDD:290200	9/44 (20%)
		zf-C2H2	1413..1435	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1415..1435	CDD:275368	7/19 (37%)
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	8/20 (40%)
		zf-H2C2_2	172..197	CDD:290200	11/29 (38%)
		zf-C2H2	186..208	CDD:278523	7/25 (28%)
		C2H2 Zn finger	188..208	CDD:275368	6/23 (26%)
		zf-C2H2_8	191..271	CDD:292531	19/83 (23%)
		zf-H2C2_2	200..227	CDD:290200	13/26 (50%)
		C2H2 Zn finger	216..238	CDD:275368	5/21 (24%)
		C2H2 Zn finger	246..266	CDD:275368	0/19 (0%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930