DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zld and hb

DIOPT Version :9

Sequence 1:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	174/884 - (19%)
Similarity:	263/884 - (29%)	Gaps:	344/884 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 GGAAMSQYSASPSP-TQQQQHHLNHHQQQANGYANGTANGYGYMQQQVQSTTNASPQHASNNNSN 731
            |.:..|....||.| |...:..|...|||              :|||...|..|.....|.|:.|
  Fly    37 GNSVASSPRQSPIPSTNHLEQFLKQQQQQ--------------LQQQPMDTLCAMTPSPSQNDQN 87

  Fly   732 NQQ-----------QQQQQQQHHQ--QQMPQHHNSVLNGH----PNGLAGPSAPHNNNTTQMPSS 779
            :.|           ||||.|||.|  ||...||:.::.|.    |.||..| ..|.......||.
  Fly    88 SLQHYDANLQQQLLQQQQYQQHFQAAQQQHHHHHHLMGGFNPLTPPGLPNP-MQHFYGGNLRPSP 151

  Fly   780 QMRGLLNETTTTPPPTT-TTRAPQITTTATTTTTAATTVAIKSEQMEDSNHTHTHTHTHPNHSHS 843
            |           |.||: :|.||....|.::....|.|                     |....:
  Fly   152 Q-----------PTPTSASTIAPVAVATGSSEKLQALT---------------------PPMDVT 184

  Fly   844 QDRSHSSSSSSSMATEEAEEQELRDQEQADDHLHQHQQASQQYLLSARHYHSSTPNTLSSSNTNP 908
            ..:|.:.||.|::..|:..:|.....|            ..:|:..:           ...:||.
  Fly   185 PPKSPAKSSQSNIEPEKEHDQMSNSSE------------DMKYMAES-----------EDDDTNI 226

  Fly   909 STPSSNSPHTI--YRQEQQG------TDF---SRTTPPPQPLPPMGMLPPMA-----MDYNMLAL 957
            ..|..||...:  |:.:..|      .||   :||...|..:......|.:.     ::|::
  Fly   227 RMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHI--- 288

  Fly   958 DMPMPMPTLMHSNM--LQCSSTSTTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQH 1020
                    ..|.|.  .||...|    .|.:..||.::.:..... |:.|:..
  Fly   289 --------RKHKNQKPFQCDKCS----YTCVNKSMLNSHRKSHSS-VYQYRCA------------ 328

  Fly  1021 QRQEADHHQQQRELHQLDQQQQQQQALILADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPLQ 1085
               :.|:..:.....:|..::...:..::.|.         ..:|.|::.:
  Fly   329 ---DCDYATKYCHSFKLHLRKYGHKPGMVLDE---------DGTPNPSLVI-------------- 367

  Fly  1086 PPPPHITSTMPMPPTMHMPIMPPPPQCYQQLQPLDPTMSYHTIIGSGPEAHTGTAGGGYSNQITT 1150
                .:..|...|.:.:                            .||.|..|:..|...:.:..
  Fly   368 ----DVYGTRRGPKSKN----------------------------GGPIASGGSGSGSRKSNVAA 400

  Fly  1151 SDGQILQLMPTSLFAPYAPLSPYSVAAQRSP--QEGDLPPVHTLTTALHAHQQGGQQEAQTPTLT 1213
            ...|..|..|..   |.| .|..|.|.|..|  |....||                  |.:|
  Fly   401 VAPQQQQSQPAQ---PVA-TSQLSAALQGFPLVQGNSAPP------------------AASP--- 440

  Fly  1214 VLSTPYSP--TVSSSRATPALEM------DMATLMQHHQDYEMEQY----------QMQHQQLDQ 1260
            ||..|.||  :|:|...||:|..      .:|:|:|.:::.....|          |.|...|.|
  Fly   441 VLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQ 505

  Fly  1261 M---------QQHQQQLDHQQQQQ--------------------ILADQTQTMAQQPLAKKRR-G 1295
            :         ||:|||.|:::::|                    :..|:.|...|||||...: .
  Fly   506 LSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQQPQQPLAMNLKVE 570

  Fly  1296 GNATP----STTKRRRN-----------SSVGSTSPHSTTLPS-----------GRIKCLE--CD 1332
            ..|||    |...||:.           .|...|||....:||           ||....|  |.
  Fly   571 EEATPLMSSSNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSPIAGRKPMPEEHCS 635

  Fly  1333 -----KEFTKNCYLTQHNKSFHSGEYP-------------------------------------- 1354
                 .|..:..::.|.|.|..|....
  Fly   636 GTSSADESMETAHVPQANTSASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAA 700

  Fly  1355 ----FRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCELC 1389
                :.|:.|...|:...:||.|:|.|...| ..||.:|
  Fly   701 AGAIYECKYCDIFFKDAVLYTIHMGYHSCDD-VFKCNMC 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	18/109 (17%)
		C2H2 Zn finger	1328..1349	CDD:275368	6/27 (22%)
		C2H2 Zn finger	1357..1377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1386..1407	CDD:275368	2/4 (50%)
		zf-H2C2_2	1398..1422	CDD:290200
		zf-C2H2	1413..1435	CDD:278523
		C2H2 Zn finger	1415..1435	CDD:275368
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	2/30 (7%)
		zf-H2C2_2	283..308	CDD:290200	7/39 (18%)
		C2H2 Zn finger	299..319	CDD:275368	5/23 (22%)
		C2H2 Zn finger	327..345	CDD:275368	2/32 (6%)
		C2H2 Zn finger	707..727	CDD:275371	7/19 (37%)
		C2H2 Zn finger	735..757	CDD:275371	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100